Protein Alignment RAB7A and Rab9Fb

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_727472.1
• Gene: Rab9Fb / 32029
• FlyBaseID: FBgn0052670
• Length: 214
• Species: Drosophila melanogaster
• Alignment Length: 219
• Identity: 77/219 - (35%)
• Similarity: 122/219 - (55%)
• Gaps: 20/219 - (9%)

Human     3 SRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQ 67
            |:...|.|:::|||.||||:.|:.::.:.:|:.::..|:|.||..:.|.:..|:|.:|||||||.
  Fly     2 SQYDYLFKILVLGDIGVGKSCLLMRFSDNRFTEKHVCTVGMDFRVRNVELAGRMVMLQIWDTAGD 66

Human    68 ERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKI-DLEN 131
            |||:||..::||||...:||:|:|:..:|:.:|.|..|....:|    |:...:::|||. ||:|
  Fly    67 ERFKSLLPSYYRGAHGILLVYDITSSKSFRNIDGWLKEIRRMSS----ESVNVMLVGNKCDDLDN 127

Human   132 RQVATKRAQAWCYSKNN-IPYFETSAKEAINVEQAFQTIA-----------RNALKQETEVELYN 184
            |||  :..|.:.|:.:. :.::|.|||...||...|..::           .|.|....|.|...
  Fly   128 RQV--RMEQGFNYANHRALGFYEVSAKSGANVNDVFNMLSVGIYNRLVIHTPNRLSGGQETEDTA 190

Human   185 EFP-EPIKLDKNDRAKASAESCSC 207
            |.| |||.|...||.:|...:..|
  Fly   191 EPPDEPINLAGKDRQRAKDSNTCC 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	63/182 (35%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		1/12 (8%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		8/14 (57%)
Rab9Fb	NP_727472.1	Rab	8..165	CDD:206640	61/162 (38%)