Protein Alignment RAB7A and Rab27

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Alignment Length: 179
• Identity: 66/179 - (36%)
• Similarity: 101/179 - (56%)
• Gaps: 7/179 - (3%)

Human    12 IILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDR----LVTMQIWDTAGQERFQS 72
            ::|||||||||.|:.||.:.:|..|:.:|:|.||..|.::.:.|    .:.:|||||||||||:|
  Fly    21 LVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERFRS 85

Human    73 LGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATK 137
            |..||||.|...:|:||:|:..:|....:|..:....|...||:   .|:.|||.||...:|.::
  Fly    86 LTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPD---VVLCGNKCDLLQLRVVSR 147

Human   138 RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEF 186
            ...|....:..:||.||||....||::|.:.:....:::........||
  Fly   148 DQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREF 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	64/170 (38%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		3/12 (25%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		10/14 (71%)
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	64/168 (38%)