DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAB7A and ypt7

DIOPT Version :9

Sequence 1:	NP_004628.4	Gene:	RAB7A / 7879	HGNCID:	9788	Length:	207	Species:	Homo sapiens
Sequence 2:	NP_596307.1	Gene:	ypt7 / 2540763	PomBaseID:	SPBC405.04c	Length:	205	Species:	Schizosaccharomyces pombe

Alignment Length:	209	Identity:	135/209 - (64%)
Similarity:	169/209 - (80%)	Gaps:	6/209 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTA 65
            |..:||.||||||||:|||||||:||||||:|||..||||||||||||||:|||::||:|:||||
pombe     1 MAGKKKHLLKVIILGESGVGKTSIMNQYVNRKFSKDYKATIGADFLTKEVLVDDKVVTLQLWDTA 65

Human    66 GQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLE 130
            ||||||||||||||||||||||:||....:|:|||||||||||||||.:||.|||::||||:|:|
pombe    66 GQERFQSLGVAFYRGADCCVLVYDVNNSKSFETLDSWRDEFLIQASPSNPETFPFILLGNKVDVE 130

Human   131 --NRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLD 193
              .|.|:..:|.|:|.::..||||||||||||||::||:|:|:.||:.....::..:|.:||.||
pombe   131 EQKRMVSKSKALAFCQARGEIPYFETSAKEAINVQEAFETVAKLALENMDSDDIAADFTDPIHLD 195

Human   194 KNDRAKASAESCSC 207
                .::...||.|
pombe   196 ----MESQKTSCYC 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	123/171 (72%)
RAB7A	NP_004628.4	Effector region. /evidence=ECO:0000250	37..45		7/7 (100%)
ypt7	NP_596307.1	Rab7	9..181	CDD:206655	123/171 (72%)
ypt7	NP_596307.1	RAB	9..178	CDD:197555	123/168 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	257	1.000	Domainoid score	I440
eggNOG	1	0.900	-	-		E1_KOG0394
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3408
Inparanoid	1	1.050	277	1.000	Inparanoid score	I784
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001661
OrthoInspector	1	1.000	-	-		oto146267
orthoMCL	1	0.900	-	-		OOG6_101358
Panther	1	1.100	-	-	LDO	PTHR47981
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2001
SonicParanoid	1	1.000	-	-		X1058
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.850