Protein Alignment RAB7A and rab-7

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_496549.1
• Gene: rab-7 / 174834
• WormBaseID: WBGene00004271
• Length: 209
• Species: Caenorhabditis elegans
• Alignment Length: 207
• Identity: 147/207 - (71%)
• Similarity: 179/207 - (86%)
• Gaps: 3/207 - (1%)

Human     3 SRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQ 67
            :|||.|||||||||||||||||||||||::|||||||||||||||::|.:|||.||:||||||||
 Worm     4 TRKKALLKVIILGDSGVGKTSLMNQYVNRRFSNQYKATIGADFLTRDVNIDDRTVTLQIWDTAGQ 68

Human    68 ERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLEN- 131
            |||||||||||||||||||.||||...:||:|||||||||||||||||::||||:||||:|||:
 Worm    69 ERFQSLGVAFYRGADCCVLAFDVTNAASFKSLDSWRDEFLIQASPRDPDHFPFVLLGNKVDLESQ 133

Human   132 RQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQET-EVELYNEFPEPIKLDKN 195
            |.|::||||:||.:|.||||:|.|||||:|||.||..|||:||.:|: |...:.|||:.|:|:.|
 Worm   134 RAVSSKRAQSWCQTKGNIPYYEVSAKEALNVEAAFLAIARDALARESQETNDFPEFPDQIRLNPN 198

Human   196 DRAKASAESCSC 207
            .:.:.:: .|:|
 Worm   199 QQNQQNS-GCNC 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	134/171 (78%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		10/12 (83%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		14/14 (100%)
rab-7	NP_496549.1	Rab7	10..181	CDD:206655	134/170 (79%)