Protein Alignment USP7 and puf

DIOPT Version :10

• Sequence 1: NP_003461.2
• Gene: USP7 / 7874
• HGNCID: 12630
• Length: 1102
• Species: Homo sapiens
• Sequence 2: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Alignment Length: 993
• Identity: 198/993 - (19%)
• Similarity: 338/993 - (34%)
• Gaps: 300/993 - (30%)

Human   205 WD------SKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRV 263
            ||      .:...|||||.|.||||||.|.:|.|:...|.|.||..:|...........|.|||:
  Fly  2000 WDYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRM 2064

Human   264 F-YELQHSDKPVGTKKLTKSF--GWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFR 325
            | |.|:...|....:...:.:  ..:.|::..|.|:.|....|:..:|:....  ::..:.:||.
  Fly  2065 FAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPD--LKHLVKRLFC 2127

Human   326 GKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQ-EA 389
            |.:.:.:...:..:.|...||:|.::..:...:|:.||..:....:.|:|||.|...:.|.: .|
  Fly  2128 GSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRA 2192

Human   390 EKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKT-------------- 440
            ||...|..||.:|....||:.::..|....|:|..|.||.:|.:..:::||
  Fly  2193 EKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQ 2257

Human   441 ------------------------DPKDPANYILHAVLVHSGDNHGGHYVVYLNPK------GDG 475
                                    |.::...|.|..|.||:|...||||..::..:      ...
  Fly  2258 KEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHE 2322

Human   476 KWCKFDD---------DVVSRCTKEEAIEHNYGGHDD---DLSVRHCTNAYMLVYIR------ES 522
            :|..|:|         .:.:.|...|.....|....:   |.|.....:||||.|.|      :.
  Fly  2323 RWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQR 2387

Human   523 KLSEVLQAVTDHDIPQQLVE---RLQEEKRIEAQKRKERQEAHLYMQV----------------Q 568
            :.||:|...|    |...||   ..:|..::|....:.:.:..:.::|                :
  Fly  2388 RHSELLVTPT----PSPTVEEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKE 2448

Human   569 IVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTK 633
            ..|:::....:......|||      |:.|.|...|   ..|:|...|.:...:     .:...|
  Fly  2449 TPAKEEIADDKSKQDEPEEK------KIEKQSREGE---EKSETDEKPTEMTTV-----STEEEK 2499

Human   634 RP-AMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATL--PKFDKD------------- 682
            :| |..||....|.:..:.|:::.|.|        ..||....|  |..:|:
  Fly  2500 QPTANCDNHQQNNNSNSKASNDQQPST--------SKAAQKLQLFRPLLNKELEDWIWQDNRQFL 2556

Human   683 HDVMLFLKMYDPKTRSLNY----CGHI------YTPISCKIRDLLPVMCDRAGFIQDTSLILYEE 737
            .|..:|...|      .|:    ||||      .|.::|....|      ...|..:|  .::.:
  Fly  2557 QDRNIFEHTY------FNFMWQICGHIPQSLISETDVTCMAAKL------SVSFFIET--FIHAK 2607

Human   738 VKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYF-----RDLYHRVDVI 797
            .||.:...:            ||:.......|:            |.|:|     ::.|..|.|:
  Fly  2608 EKPTMVPWV------------ELLTKQFNASQE------------ACEWFLSHMSQEPYWPVQVL 2648

Human   798 F-CDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRL----------NTDPMLLQFFKSQGYRDGPGN 851
            . |    ||               |:.:.:.|||          :...:.|:....:..::..|.
  Fly  2649 IQC----PN---------------QMVRQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQ 2694

Human   852 P-------------LRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQF 903
            .             |.|.....||.|.::|                        ...|.:  |:.
  Fly  2695 ASCVTRFIGSLISLLEHGARANLRHLSEYF------------------------GLLCEF--SRM 2733

Human   904 REEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLL---------EIVSYKIIGVHQEDELL 959
            .:|| .:|..:.|.::.|::     ..||.|.:..:.:.         |.:|.:.:.....|:::
  Fly  2734 GDEE-AMYLLRIGVLKSLVD-----FYLGHKQTDSIDISSDNEDNSSEEALSVEKMRPASLDKMI 2792

Human   960 ECLSPATSRT----FRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFL-------LRIHQ 1013
            ...:....|:    ||:...|.|                 ...:.|..|.|||       :..||
  Fly  2793 ALCASLVERSRGADFRLRLSPKD-----------------FSAIAGGKGFPFLYQQIKDGINPHQ 2840

Human  1014 GEHFREVMKRIQSLLDIQ 1031
            .:|....:.|....|..|
  Fly  2841 TKHLIHALCRWDERLATQ 2858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP7	NP_003461.2	Interaction with TSPYL5. /evidence=ECO:0000269|PubMed:21170034	1..208		2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		Interaction with p53/TP53, MDM2 and EBNA1. /evidence=ECO:0000269|PubMed:14506283	53..208		2/8 (25%)
		Peptidase_C19	55..1100	CDD:470612	198/993 (20%)
		Necessary for nuclear localization	70..205		198/993 (20%)
		Interaction with ICP0/VMW110. /evidence=ECO:0000269|PubMed:16160161	622..801		39/210 (19%)
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	93/370 (25%)
		DUF3517	2648..>2884	CDD:463438	44/279 (16%)
		MDN1	<3661..>3887	CDD:444083