Protein Alignment USP7 and Usp47

DIOPT Version :10

• Sequence 1: NP_003461.2
• Gene: USP7 / 7874
• HGNCID: 12630
• Length: 1102
• Species: Homo sapiens
• Sequence 2: NP_523937.2
• Gene: Usp47 / 38644
• FlyBaseID: FBgn0016756
• Length: 1556
• Species: Drosophila melanogaster
• Alignment Length: 1150
• Identity: 259/1150 - (22%)
• Similarity: 427/1150 - (37%)
• Gaps: 376/1150 - (32%)

Human   158 FFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGAT 222
            |:.::  :|.....||..|......|:  ...|.|  .:|:|...    |....|||||.||..|
  Fly   350 FYRRK--YGGDELRAWQRVNTTGADFV--SSATTE--TEAEARQA----SLGPRGYVGLVNQAMT 404

Human   223 CYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK-PVGTKKLTKSFGWE 286
            ||:|||||.||.|.:.|.|:|....:.|:.:|::|..||::|..||.|.| .|.|..||:||||:
  Fly   405 CYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWD 469

Human   287 TLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQ 351
            :.:::.|||:||||||:.|.:|:|.|.|.....|..|:.|||..|::|.|.:....|.:.:.||.
  Fly   470 STEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIP 534

Human   352 LSIK--GKKNIFESFVD----YVAVEQLDGDNKYDAGEHGLQ-EAEKGVKFLTLPPVLHLQLMRF 409
            |.::  |..:.:.|..:    :|..|.|||:|:|...:...: :|.||:.|.:.|.:|.|.|.||
  Fly   535 LPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRF 599

Human   410 MYDPQTDQNIKINDRFEFPEQLPLDEFLQKT---------------------------------- 440
            .:|.||...||:|||..||:.|.|:.|:.::
  Fly   600 DFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSG 664

Human   441 ------------DPKD--------------------PANYILHAVLVHSGDNHGGHYVVYLNPKG 473
                        |..|                    |..|.|.|:::|||...||||..|:....
  Fly   665 VVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFD 729

Human   474 DGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDL---SVRHCTNAYMLVYIR-ESKLSEVLQAVTDH 534
            :.:|..|:|..|:..|:|: |:.::||.:...   :....||||||:|.: ::|.:|::..|.
  Fly   730 NNEWFCFNDQNVTSITQED-IQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDAKRNELVAKVA-- 791

Human   535 DIPQQLVERL-----QEEKRIEAQKR------------------------KERQEAHLYM----Q 566
            |.|:.:...|     :||.|:....|                        |:.:...:|:    .
  Fly   792 DFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQSFN 856

Human   567 VQIVAEDQFCGHQGNDMYDEEK---------VKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRL 622
            :.:|....:      :|.:.|:         |.|       |||:...:|||.........::|.
  Fly   857 INLVLMSAY------EMLNVEQFAPLSRCRLVAY-------NSSMDTIIQSLESCTDPALTELRA 908

Human   623 -------WPMQARSNGTKRPAMLDNEADGNKTMIELSD--NENPWTIFLETVDPE---------- 668
                   :.::.|:...:......|........::||.  .:.|:.::....:.|
  Fly   909 AQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREASDVLRRSIA 973

Human   669 -----------LAASGATLPKFDKDHD-------VMLFLKMYDPKTRSLNYCGHIYTP-ISCKIR 714
                       ||...||:||....:|       :.....|.:.:.:|:.|. ::..| ......
  Fly   974 LRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYF-YLNVPNTDAATL 1037

Human   715 DLL------PVMCDRAGFIQDTSLILYEEVKPNLTERIQDYD----------------------- 750
            ::|      .|.|...|.:.|.:::  ..|.|.......|||
  Fly  1038 EMLGVPTVESVECASGGDVVDAAMM--NGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGHES 1100

Human   751 VSLDKALDELMDGDIIVFQKDD----------------------PENDNSE-------------- 779
            .|.|.:|.   |||..:.:.|:                      ||::.:.
  Fly  1101 NSEDSSLS---DGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAYCNGN 1162

Human   780 -------------LPTAKEYFRDLY----HRVDVIFCDKTIPNDPG-------------FVVTLS 814
                         |||:..:|  .|    ..|||:....:..:...             .:|...
  Fly  1163 GSYAAADVVDPLLLPTSTNHF--FYATKVECVDVVGTGSSSGHQSDEEAQLRKPTRAYKLLVGTH 1225

Human   815 NRMNYFQVAKTVAQRLNTDPMLLQ----FFKSQGYRD-----GPGNPLRHNYEG-TLR-DLLQFF 868
            .||..|:  |.:.|       |:|    .||.|...|     ...|.|.|..|| ||. :|.:..
  Fly  1226 MRMGAFK--KHIEQ-------LIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGETLTVELGKTL 1281

Human   869 KPRQPK-KLYYQQLKMKITDFENRRS-FKC----------------------------------- 896
            :|.:.| |:::    :::.|.:|..| ..|
  Fly  1282 EPDEFKAKIHF----LRLADIDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRIDAKYATLSV 1342

Human   897 ----IWLNS-----QFREEEITLYPDKHGCV--RDLLEECKKAVELGEKASGKLRL--------- 941
                |||..     :...::.|||.|....:  ..:::||::.|:...| ...|.|
  Fly  1343 QNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPK-DDSLTLFVRRWCPAK 1406

Human   942 LEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKEN 986
            ||...::.|.:.|:.|:...||       :|.:||:|::...|.|
  Fly  1407 LEFGKFQEITLDQDSEIRLSLS-------QISDIPIDKLSYMKLN 1444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP7	NP_003461.2	Interaction with TSPYL5. /evidence=ECO:0000269|PubMed:21170034	1..208		10/49 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		Interaction with p53/TP53, MDM2 and EBNA1. /evidence=ECO:0000269|PubMed:14506283	53..208		10/49 (20%)
		Peptidase_C19	55..1100	CDD:470612	258/1149 (22%)
		Necessary for nuclear localization	70..205		10/46 (22%)
		Interaction with ICP0/VMW110. /evidence=ECO:0000269|PubMed:16160161	622..801		44/298 (15%)
Usp47	NP_523937.2	DUF4045	<122..249	CDD:433066
		peptidase_C19C	394..780	CDD:239124	127/386 (33%)
		USP47_C	1300..1534	CDD:466158	28/152 (18%)