Protein Alignment USP7 and Usp7

DIOPT Version :10

• Sequence 1: NP_003461.2
• Gene: USP7 / 7874
• HGNCID: 12630
• Length: 1102
• Species: Homo sapiens
• Sequence 2: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Alignment Length: 1133
• Identity: 550/1133 - (48%)
• Similarity: 759/1133 - (66%)
• Gaps: 66/1133 - (5%)

Human     5 QQQQQQKAGEQQLSEPEDM---EMEAGDTDDPPRITQNPVINGNV----ALSDGHNTAEEDME-- 60
            ||.|||:....||.:.:::   ::.|...     :||.|..|||:    .|:|..:|:..|.|
  Fly    28 QQTQQQRNSPPQLPKFKNLIQPQLHAVGA-----VTQLPSENGNMPPQQLLADSSSTSFGDGEAM 87

Human    61 --DDTS----WRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFL 119
              ||.|    :|||.||.||||...:|....||||.:||.|||:|||:       |:.:::||||
  Fly    88 GIDDESKEDQFRSETTFSFTVENVVQLKSQRLSPPVYVRMLPWRIMVI-------PNDRALGFFL 145

Human   120 QCNAESDSTSWSCHAQAVLKIINYRDDEKSFSR-RISHLFFHKENDWGFSNFMAWSEVTDPEKGF 183
            |||.|:||.:|||:|.|.|::..::.|.:.|:| ||.|||:.||||:|:|||:.|.|:.|.||.:
  Fly   146 QCNGENDSPTWSCNAIAELRLKCHKPDAQPFTRARIKHLFYSKENDYGYSNFITWQELKDSEKSY 210

Human   184 IDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTE 248
            :.::.:|.||.|.|||||||.||||||||||||||||||||||||||||:|||.||.:||.:|||
  Fly   211 VHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTE 275

Human   249 GDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKG 313
            .|||||||.|:|||||:|||..|:||||||||||||||||||||||||||..|||||.:|:||||
  Fly   276 ADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKG 340

Human   314 TCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNK 378
            |.:|||||.||.|||.|||:||.|||.|.|.|.:|||||:||.||||:|||.||||.|.|:||||
  Fly   341 TILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNK 405

Human   379 YDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPK 443
            ||||.||||||.|||.|.:.||||||.||||.|||.||.:||.||||||.|.:.||.:|.::: .
  Fly   406 YDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESE-N 469

Human   444 DPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVR 508
            ..|:|:||||||||||||||||||::|||.||:|.||||||||.|.|:||||.||||.||::|..
  Fly   470 TLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFH 534

Human   509 -HCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAE 572
             .|:|||||||||:|:|..||..:|:.:|...|||||..|||||..:||||.||:.|:.|.::.|
  Fly   535 AKCSNAYMLVYIRQSELDRVLGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVILE 599

Human   573 DQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAM 637
            :.|.......::|.|||...||::.:|.::.|.|....:..|..:.::|:|.:....  |::.:.
  Fly   600 ENFEEQHKRRLFDLEKVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQ--TQKFSH 662

Human   638 LDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYC 702
            .|..|:|::|:.::|.::.||.|:|:....::.   ..||.|:...:.:||||.|||:.:.|||.
  Fly   663 FDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVP---GPLPPFNPKTESLLFLKYYDPRNKRLNYI 724

Human   703 GHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKP----NLTERIQDYDVSLDKAL---DEL 760
            |....|.:.::.||:|.:..:.||..||.|.:|:|...    ||.|.|       :.||   .:.
  Fly   725 GCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPI-------ESALFIPQDH 782

Human   761 MDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKT 825
            :.|.|::|::::.: ...:|||..:||.||.:|:::||.||..||:|.|.:.||||.||.|:|..
  Fly   783 LQGHILIFERENVD-AKLDLPTVGDYFLDLVYRIEIIFSDKCNPNEPDFTLELSNRYNYDQLANA 846

Human   826 VAQRLNTDPMLLQFFKS-QGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFE 889
            ||:||||||..||||.. ..|::..||.:.:.::||::||:.:.|....|:::||:|.:.|.:.:
  Fly   847 VAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLSIHELD 911

Human   890 NRRSFKCIWLNSQFREE-EITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVH 953
            |::.|||:|::|..::| |:.|||:|:..|:.||||..|.:...|.:..|||||:|.::||:.|.
  Fly   912 NKKQFKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVC 976

Human   954 QEDELLECL---------SPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLL 1009
            ::|..|:.|         :....:||||||:|.:.:.: .|||.|:.||||.||::.:||||||.
  Fly   977 KDDIPLDTLLKSNESITTAQGAQKTFRIEEVPAEDMQL-AENEFLIPVAHFSKELYNSFGIPFLT 1040

Human  1010 RIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPR 1074
            :..|||.:..:.:|||..|::|:||:|.:||.::.||.:..:| |...|:|:.:...   .|...
  Fly  1041 KARQGEPYGALKQRIQRRLNVQDKEWENYKFCVISMGHNADVN-DNTPVDLEVYRSW---TSGQL 1101

Human  1075 PWLGLDHFNKAPKRSRYTYLEKAIKIHN 1102
            |:.||||.||:.|||...:.||||||:|
  Fly  1102 PFFGLDHINKSRKRSSLNFSEKAIKIYN 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP7	NP_003461.2	Interaction with TSPYL5. /evidence=ECO:0000269|PubMed:21170034	1..208		95/218 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		8/35 (23%)
		Interaction with p53/TP53, MDM2 and EBNA1. /evidence=ECO:0000269|PubMed:14506283	53..208		79/163 (48%)
		Peptidase_C19	55..1100	CDD:470612	530/1072 (49%)
		Necessary for nuclear localization	70..205		68/135 (50%)
		Interaction with ICP0/VMW110. /evidence=ECO:0000269|PubMed:16160161	622..801		55/185 (30%)
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	519/1043 (50%)