Protein Alignment MANF and Manf

DIOPT Version :10

• Sequence 1: NP_006001.5
• Gene: MANF / 7873
• HGNCID: 15461
• Length: 182
• Species: Homo sapiens
• Sequence 2: NP_477445.1
• Gene: Manf / 41983
• FlyBaseID: FBgn0027095
• Length: 173
• Species: Drosophila melanogaster
• Alignment Length: 167
• Identity: 87/167 - (52%)
• Similarity: 118/167 - (70%)
• Gaps: 11/167 - (6%)

Human     9 GLAVALALSVLPGSRALRPGDCEVCISYLGRFYQDLKD---RDVTFSPATIENELIKFCREARGK 70
            |....||.:    |.||:..|||||:..:.||...|.|   :|.    ..||....|||:..:.|
  Fly    11 GFLATLAQT----SLALKEEDCEVCVKTVRRFADSLDDSTKKDY----KQIETAFKKFCKAQKNK 67

Human    71 ENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKL 135
            |:|.|||:|..:::||.|:||:||||:..:|.|||||||||||:|||:|:|:|||||::||||||
  Fly    68 EHRFCYYLGGLEESATGILNELSKPLSWSMPAEKICEKLKKKDAQICDLRYEKQIDLNSVDLKKL 132

Human   136 RVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYA 172
            :|::|||||:||.|:|.||.||.|:|::|.||.|||:
  Fly   133 KVRDLKKILNDWDESCDGCLEKGDFIKRIEELKPKYS 169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MANF	NP_006001.5	ARMET_N	29..125	CDD:466306	49/98 (50%)
		Interacts with ERN1, EIF2AK3 and ATF6. /evidence=ECO:0000269|PubMed:36739529	96..158		42/61 (69%)
		Interacts with HSPA5. /evidence=ECO:0000250|UniProtKB:Q9CXI5	129..172		27/42 (64%)
		ARMET_C	129..171	CDD:462997	26/41 (63%)
Manf	NP_477445.1	ARMET_N	27..122	CDD:466306	49/98 (50%)
		ARMET_C	126..168	CDD:462997	26/41 (63%)