DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SEMA3B and Sema1a

DIOPT Version :9

Sequence 1:	NP_001276990.1	Gene:	SEMA3B / 7869	HGNCID:	10724	Length:	754	Species:	Homo sapiens
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	209/739 - (28%)
Similarity:	324/739 - (43%)	Gaps:	122/739 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    59 LVDEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAY 123
            ||.::...|.:||.|.|.:|::.::.:: ::|.|.:|.:..:.|...||| ...|.|:::::...
  Fly    99 LVTKDGNSLLIGARNTVFNLSIHDLVEQ-QRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVP 161

Human   124 NRTHLLACGTGAFHPTC---AFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
            :...|..|||.:|.|.|   ...:..:..|         ..::|:...||||||.:.|||...||
  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLE---------ATKNGQAVCPYDPRHNSTSVLADNEL 217

Human   186 YSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETA 250
            |||..||..|.|..|:|.     .|:||.:||..||.|.||..|       ...|.:||||||||
  Fly   218 YSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSF-------TQGDFVYFFFRETA 270

Human   251 VEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLRPFPAEDV 315
            ||.... |:...|||.::|:.|.||.....|:||:|||:||.||:|| :...:|::::  .|.::
  Fly   271 VEFINC-GKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG-DYPFYFNEIQ--SASNL 331

Human   316 FLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSY-QGRVPY 379
            .........:.|:|.||:|.|:...|||||.:::.|:...|.|.|..:.|....|:.. ..:||.
  Fly   332 VEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396

Human   380 PRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVA 444
            ||||.|       .:.::..||..:.|.:.|.||..:|.....:|:.::....|.|||||.|...
  Fly   397 PRPGSC-------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQI 454

Human   445 AADG--HYDVLFIGTDVGTVLKVISVPKGSRPSAE---GLLLEELHVFEDSAAVTSMQI------ 498
            ...|  .|||:|:|||.|.::|  ||...|..||:   .:::||:.|...|..:.:::|
  Fly   455 KTPGGKTYDVIFVGTDHGKIIK--SVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQY 517

Human   499 ------SSKRHQLYVASRSAVAQIALHRCAAHG---RVCTECCLARDPYCAWDGVACTRFQPSAK 554
                  |....:|.:.:.|.|..|.||||  |.   ..|:||...:|||||||.:|.......|.
  Fly   518 DQPKDGSYDDGKLIIVTDSQVVAIQLHRC--HNDKITSCSECVALQDPYCAWDKIAGKCRSHGAP 580

Human   555 R----RFRRQDVRNGDPSTLCSGD-SSRPALL-EHKVFGVEGSSAFLECEPRS----LQARVEWT 609
            |    .:..|:|..|..:...||. :|:.|.. |.|  |.......|:...:|    :...::..
  Fly   581 RWLEENYFYQNVATGQHAACPSGKINSKDANAGEQK--GFRNDMDLLDSRRQSKDQEIIDNIDKN 643

Human   610 FQRAGVTA---HTQVLAEERTERTARGLLLRRLRRRDSGVYLCAA--------------VEQGFT 657
            |:...::|   :.|...|........|.:...|....:| |.|..              .|..:.
  Fly   644 FEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTG-YFCGRRCHKDEDDNLPYPDTEYEYF 707

Human   658 QPLRRLSLHVLSA---------TQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLR 713
            :..:.::....|.         .|.|.:..||......||.|.                     :
  Fly   708 EQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN---------------------K 751

Human   714 MCRPQPALQSLPLESRRKGRNRRT 737
            |..|:..|:..|:....:|.|..|
  Fly   752 MHSPKNTLRKPPMHQMHQGPNSET 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEMA3B	NP_001276990.1	Sema	46..521	CDD:301699	156/482 (32%)
		PSI	520..>556	CDD:214655	16/42 (38%)
		Ig_Semaphorin_classIII	580..670	CDD:143279	15/111 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..754		7/31 (23%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	156/482 (32%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/35 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920