Protein Alignment SEMA3B and Sema1a

DIOPT Version :10

• Sequence 1: NP_001276990.1
• Gene: SEMA3B / 7869
• HGNCID: 10724
• Length: 754
• Species: Homo sapiens
• Sequence 2: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 209/739 - (28%)
• Similarity: 324/739 - (43%)
• Gaps: 122/739 - (16%)

Human    59 LVDEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAY 123
            ||.::...|.:||.|.|.:|::.::.:: ::|.|.:|.:..:.|...||| ...|.|:::::...
  Fly    99 LVTKDGNSLLIGARNTVFNLSIHDLVEQ-QRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVP 161

Human   124 NRTHLLACGTGAFHPTC---AFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
            :...|..|||.:|.|.|   ...:..:..|         ..::|:...||||||.:.|||...||
  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLE---------ATKNGQAVCPYDPRHNSTSVLADNEL 217

Human   186 YSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETA 250
            |||..||..|.|..|:|.     .|:||.:||..||.|.||..|       ...|.:||||||||
  Fly   218 YSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSF-------TQGDFVYFFFRETA 270

Human   251 VEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLRPFPAEDV 315
            ||.... |:...|||.::|:.|.||.....|:||:|||:||.||:|| :...:|::::  .|.::
  Fly   271 VEFINC-GKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG-DYPFYFNEIQ--SASNL 331

Human   316 FLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSY-QGRVPY 379
            .........:.|:|.||:|.|:...|||||.:::.|:...|.|.|..:.|....|:.. ..:||.
  Fly   332 VEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396

Human   380 PRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVA 444
            ||||.|       .:.::..||..:.|.:.|.||..:|.....:|:.::....|.|||||.|...
  Fly   397 PRPGSC-------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQI 454

Human   445 AADG--HYDVLFIGTDVGTVLKVISVPKGSRPSAE---GLLLEELHVFEDSAAVTSMQI------ 498
            ...|  .|||:|:|||.|.::|  ||...|..||:   .:::||:.|...|..:.:::|
  Fly   455 KTPGGKTYDVIFVGTDHGKIIK--SVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQY 517

Human   499 ------SSKRHQLYVASRSAVAQIALHRCAAHG---RVCTECCLARDPYCAWDGVACTRFQPSAK 554
                  |....:|.:.:.|.|..|.||||  |.   ..|:||...:|||||||.:|.......|.
  Fly   518 DQPKDGSYDDGKLIIVTDSQVVAIQLHRC--HNDKITSCSECVALQDPYCAWDKIAGKCRSHGAP 580

Human   555 R----RFRRQDVRNGDPSTLCSGD-SSRPALL-EHKVFGVEGSSAFLECEPRS----LQARVEWT 609
            |    .:..|:|..|..:...||. :|:.|.. |.|  |.......|:...:|    :...::..
  Fly   581 RWLEENYFYQNVATGQHAACPSGKINSKDANAGEQK--GFRNDMDLLDSRRQSKDQEIIDNIDKN 643

Human   610 FQRAGVTA---HTQVLAEERTERTARGLLLRRLRRRDSGVYLCAA--------------VEQGFT 657
            |:...::|   :.|...|........|.:...|....:| |.|..              .|..:.
  Fly   644 FEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTG-YFCGRRCHKDEDDNLPYPDTEYEYF 707

Human   658 QPLRRLSLHVLSA---------TQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLR 713
            :..:.::....|.         .|.|.:..||......||.|.                     :
  Fly   708 EQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN---------------------K 751

Human   714 MCRPQPALQSLPLESRRKGRNRRT 737
            |..|:..|:..|:....:|.|..|
  Fly   752 MHSPKNTLRKPPMHQMHQGPNSET 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEMA3B	NP_001276990.1	Sema	46..521	CDD:472829	156/482 (32%)
		PSI	520..>556	CDD:214655	16/42 (38%)
		Ig	579..670	CDD:472250	16/112 (14%)
		Ig strand B	593..597	CDD:409353	1/3 (33%)
		Ig strand C	605..609	CDD:409353	0/3 (0%)
		Ig strand E	632..636	CDD:409353	1/3 (33%)
		Ig strand F	646..651	CDD:409353	2/4 (50%)
		Ig strand G	663..666	CDD:409353	0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..754		7/31 (23%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	156/482 (32%)
		PSI	545..601	CDD:396154	19/57 (33%)