| Sequence 1: | NP_003459.2 | Gene: | FZD5 / 7855 | HGNCID: | 4043 | Length: | 585 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001262037.1 | Gene: | fz2 / 40090 | FlyBaseID: | FBgn0016797 | Length: | 806 | Species: | Drosophila melanogaster |
| Alignment Length: | 678 | Identity: | 342/678 - (50%) |
|---|---|---|---|
| Similarity: | 405/678 - (59%) | Gaps: | 137/678 - (20%) |
- Green bases have known domain annotations that are detailed below.
|
Human 22 GRAAAASKAP-------------VCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPL 73
Human 74 VEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPV 138
Human 139 LGRDAEVLCMDY------------------------------------------NRSEATTAPPR 161
Human 162 PFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFV--------------PILKESHPLYNKV-- 210
Human 211 -RTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFL 274
Human 275 SACYLCVSLGFLVRLVVGHASVACS----REHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVI 335
Human 336 LSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSL 400
Human 401 RGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVP 460
Human 461 ASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGK 525
Human 526 TVESWRRFTSRCCCRPRR-------------------GHKSG-------GAMAAGDYPEASAALT 564
Human 565 GRTGPPGPAATYH-------KQVSLSHV 585 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD5 | NP_003459.2 | TM helix 5 | 397..426 | CDD:320377 | 16/28 (57%) |
| TM helix 6 | 446..473 | CDD:320377 | 21/26 (81%) | ||
| TM helix 7 | 496..521 | CDD:320377 | 19/24 (79%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 525..530 | 3/4 (75%) | |||
| PDZ-binding | 583..585 | 1/1 (100%) | |||
| CRD_FZ5 | 29..156 | CDD:143569 | 90/181 (50%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 156..179 | 7/22 (32%) | |||
| 7tmF_FZD5 | 225..535 | CDD:320377 | 207/318 (65%) | ||
| TM helix 1 | 234..259 | CDD:320377 | 15/24 (63%) | ||
| TM helix 2 | 268..289 | CDD:320377 | 13/20 (65%) | ||
| TM helix 3 | 316..342 | CDD:320377 | 22/25 (88%) | ||
| TM helix 4 | 359..375 | CDD:320377 | 12/15 (80%) | ||
| fz2 | NP_001262037.1 | CRD_FZ5_like | 63..182 | CDD:143565 | 88/119 (74%) |
| Frizzled | 308..618 | CDD:279827 | 206/317 (65%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165141198 | |
| Domainoid | 1 | 1.000 | 415 | 1.000 | Domainoid score | I666 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H2590 | |
| Inparanoid | 1 | 1.050 | 639 | 1.000 | Inparanoid score | I821 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG49270 | |
| OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0003114 | |
| OrthoInspector | 1 | 1.000 | - | - | oto90246 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_106776 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11309 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4396 |
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.800 | |||||