DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FZD5 and Corin

DIOPT Version :9

Sequence 1:	NP_003459.2	Gene:	FZD5 / 7855	HGNCID:	4043	Length:	585	Species:	Homo sapiens
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	70/330 - (21%)
Similarity:	116/330 - (35%)	Gaps:	76/330 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    30 AP-VCQEITVPMCRG--IGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYT 91
            || .|..|.|..|:|  |.||.|..||...|..|.|...::..:..||:::|...:..|||:::.
  Fly   775 APGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFV 839

Human    92 PICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRS--E 154
            |.| ......:|||:::|......|......:|.:.||.::|..........:.:.:|..|.  .
  Fly   840 PKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMR 903

Human   155 ATTAPP---------RPFPAKPTLPGPPGA--PASGGECPAGGPFVCKCREPFVPILKESHPLYN 208
            |.|.|.         |..|.:....|....  .|...:|...||....|.:.            .
  Fly   904 AATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDS------------Q 956

Human   209 KVRTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIF 273
            .:.|..:.:..:.|   .:..|||          :.|.....:..|.|.::::  :|..:|.  :
  Fly   957 CIGTKHICDGIIDC---PYGQDER----------NCLRLSERNGDVGTGVLEV--YRIGQRQ--W 1004

Human   274 LSACY-----------LCVSLGFLVRLVVGHASVACSREHNHIHYETTGPALCTIVFLLVYFFGM 327
            :.||.           :|..||:   ..|...||.....|.        |.|.|:        .:
  Fly  1005 MPACVKNWDRAVSPSAVCSILGY---SAVNATSVLTQLTHR--------PLLATV--------NV 1050

Human   328 ASSIW 332
            ::.||
  Fly  1051 STDIW 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FZD5	NP_003459.2	TM helix 5	397..426	CDD:320377
		TM helix 6	446..473	CDD:320377
		TM helix 7	496..521	CDD:320377
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	525..530
		PDZ-binding	583..585
		CRD_FZ5	29..156	CDD:143569	35/130 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..179		6/33 (18%)
		7tmF_FZD5	225..535	CDD:320377	22/119 (18%)
		TM helix 1	234..259	CDD:320377	3/24 (13%)
		TM helix 2	268..289	CDD:320377	6/31 (19%)
		TM helix 3	316..342	CDD:320377	3/17 (18%)
		TM helix 4	359..375	CDD:320377
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	31/116 (27%)
		LDLa	911..942	CDD:238060	4/30 (13%)
		LDLa	945..979	CDD:238060	8/58 (14%)
		SR	980..>1034	CDD:214555	11/60 (18%)
		SRCR	992..1086	CDD:278931	16/87 (18%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810