Protein Alignment CXCR4 and FMRFaR

DIOPT Version :9

• Sequence 1: NP_001334985.1
• Gene: CXCR4 / 7852
• HGNCID: 2561
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_001261347.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Alignment Length: 414
• Identity: 81/414 - (19%)
• Similarity: 162/414 - (39%)
• Gaps: 69/414 - (16%)

Human     9 PLPNV-PNAPSDKHEDGK-RPTHRRSARLGEEVPFVHFLTLPPNIPQAPKGLRFKTAFSLPTTS- 70
            |.|.| |..|:|....|. ......::.:..|.|.|.:...|.|..|             ||..
  Fly    16 PSPGVMPPPPTDYDYGGPISDDEFLASAMATEGPTVRYDLFPQNNSQ-------------PTLQI 67

Human    71 CLKPRMIYTSDNYT--EEMG---SGDYDSMKEPCFRE--ENANFNKIFLPTIYSIIFLTGIVGNG 128
            .|....:.|...|.  |::|   ..::..:.|..:..  ||..........:.:|:.:.||:||.
  Fly    68 VLNHTEVQTDLQYPHYEDLGLDPDPNWTRICEDVYNPLLENNRIEFWVCGVLINIVGVLGILGNI 132

Human   129 LVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT------LPFWAVDAVANWYFG------NFLCK 181
            :.::::. :.::||..:.....|:..|.:.:||      :|  ::......:||      .|:..
  Fly   133 ISMIILS-RPQMRSSINYLLTGLARCDTVLIITSILLFGIP--SIYPYTGHFFGYYNYVYPFISP 194

Human   182 AVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDF--- 243
            ||..|..:...:|:.:...::|:||:|:.|...::........|:.::.....:|...:|.|
  Fly   195 AVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEV 259

Human   244 IFANVSEADDRYI--C---DRFYPNDLWVVVF-QFQHIMVGLILPGIVILSCYCIII-------- 294
            :.....|.....|  |   .|...::.::.:: .:.:::|..|:|.:.:....|:|.
  Fly   260 LTVTYPEPGKDVILHCVRPSRLRRSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANR 324

Human   295 --SKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISI 357
              .:||.|:..:...|.....::|:.|...:||..:.|| ::|           :....||...|
  Fly   325 ERQRLSRSEKREIGLATMLLCVVIVFFMLNFLPLVLNIS-EAF-----------YSTIDHKITKI 377

Human   358 TEALAFFHCCLNPILYAFLGAKFK 381
            :..|...:..:|.::|...|.|||
  Fly   378 SNLLITINSSVNFLIYIIFGEKFK 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CXCR4	NP_001334985.1	CXCR4_N	77..109	CDD:314911	7/38 (18%)
		7tmA_CXCR4	110..384	CDD:320307	58/303 (19%)
		TM helix 1	110..137	CDD:320307	5/26 (19%)
		TM helix 2	144..169	CDD:320307	5/30 (17%)
		TM helix 3	180..210	CDD:320307	8/29 (28%)
		TM helix 4	222..244	CDD:320307	4/24 (17%)
		TM helix 5	267..296	CDD:320307	5/39 (13%)
		TM helix 6	303..333	CDD:320307	7/29 (24%)
		TM helix 7	352..377	CDD:320307	6/24 (25%)
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	53/286 (19%)
		7tm_1	130..393	CDD:278431	50/277 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910