Protein Alignment CXCR4 and 5-HT1B

DIOPT Version :9

• Sequence 1: NP_001334985.1
• Gene: CXCR4 / 7852
• HGNCID: 2561
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 622
• Identity: 99/622 - (15%)
• Similarity: 172/622 - (27%)
• Gaps: 305/622 - (49%)

Human    44 FLTLPPNIPQAPKGLRFKTAFSLPTTSCLKPRMIYTSDNYTEEMGSGDYDSMKEPCFREENAN-- 106
            |:.|..|:.|.           :.|||.|...:...|.|     |:|:.::.......:|.|.
  Fly    35 FIELNGNLTQL-----------VDTTSNLSQIVWNRSIN-----GNGNSNTFDLVDDEQERAAVE 83

Human   107 ----FNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFV--ITLPFW 165
                ...|.:..:..::.|..|:||..||..:..::.|:::.:.....|:||| |||  :.:|..
  Fly    84 FWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVAD-LFVACLVMPLG 147

Human   166 AVDAVAN-WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAI--VHATNSQRPRKLLAEKVV 227
            ||..::| |..|..||........:...:|:|.|..|:.|||..:  :...|.:.||::.   ::
  Fly   148 AVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLRTPRRVF---LM 209

Human   228 YVGVWIPALLLTI--------PDF------------------IFANVSEADDRYICDRFYPNDLW 266
            ...||..||::::        ||:                  |||.         |..||. .|.
  Fly   210 IFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFAT---------CCTFYV-PLL 264

Human   267 VVVFQFQHIMV----------------------------------------------GLILP--- 282
            |::|.:..|.:                                              |...|
  Fly   265 VILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDG 329

Human   283 ---------------------------------GIVILSCYCIII-------------------- 294
                                             |.|..|...|.:
  Fly   330 DGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYD 394

Human   295 -------------------------------SKLSHSKGH------------------------- 303
                                           .:::|:..|
  Fly   395 NKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCL 459

Human   304 ----------------------------------------------------------------- 303
                                                                             
  Fly   460 TTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLL 524

Human   304 ---QKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFH 365
               ::|||.:|..|:..||..||||:::     ..:.:.:.|: ||....|   .|:...|.:|:
  Fly   525 EAKRERKAAQTLAIITGAFVICWLPFFV-----MALTMSLCKE-CEIHTAV---ASLFLWLGYFN 580

Human   366 CCLNPILYAFLGAKFKTSAQHAL---TSVSRGSSLKI 399
            ..|||::|.....:|:.:.:..|   .:.:|..|.||
  Fly   581 STLNPVIYTIFNPEFRRAFKRILFGRKAAARARSAKI 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CXCR4	NP_001334985.1	CXCR4_N	77..109	CDD:314911	6/37 (16%)
		7tmA_CXCR4	110..384	CDD:320307	80/530 (15%)
		TM helix 1	110..137	CDD:320307	7/26 (27%)
		TM helix 2	144..169	CDD:320307	10/26 (38%)
		TM helix 3	180..210	CDD:320307	8/31 (26%)
		TM helix 4	222..244	CDD:320307	6/47 (13%)
		TM helix 5	267..296	CDD:320307	9/161 (6%)
		TM helix 6	303..333	CDD:320307	12/122 (10%)
		TM helix 7	352..377	CDD:320307	7/24 (29%)
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	46/194 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910