DRSC/TRiP Functional Genomics Resources

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Protein Alignment CXCR4 and AkhR

DIOPT Version :9

Sequence 1:NP_001334985.1 Gene:CXCR4 / 7852 HGNCID:2561 Length:423 Species:Homo sapiens
Sequence 2:NP_995639.1 Gene:AkhR / 33942 FlyBaseID:FBgn0025595 Length:455 Species:Drosophila melanogaster


Alignment Length:356 Identity:75/356 - (21%)
Similarity:140/356 - (39%) Gaps:98/356 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   114 TIYSIIFLTGIVGNGLVILVMGYQKKLRS--MTDKYRLHLSVADLLFVITL-PF-----WAVDAV 170
            |:|||:|:...:||..|:.:: .:::||.  ..|...:||::|||:..:.| |.     |.|   
  Fly    43 TVYSILFVISTIGNSTVLYLL-TKRRLRGPLRIDIMLMHLAIADLMVTLLLMPMEIVWAWTV--- 103

Human   171 ANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRP--RKLLAEKVVYVGVWI 233
             .|...:.:|:.:.......||.|..::..||||||.||:      :|  |.....:::....|:
  Fly   104 -QWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRYFAIL------KPLKRSYNRGRIMLACAWL 161

Human   234 PALLLTIPDFIFANVSE---ADDRYICDRF--YPNDLWVVVFQFQHIMVGLILPGIVILSCY--- 290
            .:::.:||.....::.|   ....:.|..|  :.:|....::|...:......|.|:.:.||   
  Fly   162 GSVVCSIPQAFLFHLEEHPAVTGYFQCVIFNSFRSDFDEKLYQAASMCSMYAFPLIMFIYCYGAI 226

Human   291 -------------CIIISKLSHSK----GHQKRKALKTTVILILAFFACWLPYYIGISIDSFILL 338
                         .:|..:...|.    ...|::.||.|:.:::.|..||.|||           
  Fly   227 YLEIYRKSQRVLKDVIAERFRRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYY----------- 280

Human   339 EIIKQGCEFENTVHKWI------------SITEALAFF---HCCLNPILYAFLGAKFKTSAQHAL 388
                       |:..|.            .:.:||..|   :.|:||::|.....:.:.:..:  
  Fly   281 -----------TISMWYWLDKHSAGKINPLLRKALFIFASTNSCMNPLVYGLYNIRGRMNNNN-- 332

Human   389 TSVSRGSSLKILSKGKRGGHSSVSTESESSS 419
            .||:             ..|:|:|...:||:
  Fly   333 PSVN-------------NRHTSLSNRLDSSN 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CXCR4NP_001334985.1 CXCR4_N 77..109 CDD:314911
7tmA_CXCR4 110..384 CDD:320307 68/319 (21%)
TM helix 1 110..137 CDD:320307 8/22 (36%)
TM helix 2 144..169 CDD:320307 10/30 (33%)
TM helix 3 180..210 CDD:320307 11/29 (38%)
TM helix 4 222..244 CDD:320307 3/21 (14%)
TM helix 5 267..296 CDD:320307 6/44 (14%)
TM helix 6 303..333 CDD:320307 10/29 (34%)
TM helix 7 352..377 CDD:320307 8/39 (21%)
AkhRNP_995639.1 7tm_1 55..319 CDD:278431 62/296 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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