DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CXCR4 and Cxcr4

DIOPT Version :9

Sequence 1:	NP_001334985.1	Gene:	CXCR4 / 7852	HGNCID:	2561	Length:	423	Species:	Homo sapiens
Sequence 2:	NP_034041.2	Gene:	Cxcr4 / 12767	MGIID:	109563	Length:	359	Species:	Mus musculus

Alignment Length:	352	Identity:	317/352 - (90%)
Similarity:	336/352 - (95%)	Gaps:	5/352 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    77 IYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLR 141
            |||||||:||:|||||||.||||||:||.:||:|||||||.||||||||||||||||||||||||
Mouse     8 IYTSDNYSEEVGSGDYDSNKEPCFRDENVHFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLR 72

Human   142 SMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRY 206
            ||||||||||||||||||||||||||||:|:||||.|||||||:|||||||||||||||||||||
Mouse    73 SMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRY 137

Human   207 LAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANV-----SEADDRYICDRFYPNDLW 266
            |||||||||||||||||||.||||||||||||||||||||:|     |:.||||||||.||:.||
Mouse   138 LAIVHATNSQRPRKLLAEKAVYVGVWIPALLLTIPDFIFADVSQGDISQGDDRYICDRLYPDSLW 202

Human   267 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGIS 331
            :||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse   203 MVVFQFQHIMVGLVLPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGIS 267

Human   332 IDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSS 396
            |||||||.:|||||:||:.|||||||||||||||||||||||||||||||:||||||.|:|||||
Mouse   268 IDSFILLGVIKQGCDFESIVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSS 332

Human   397 LKILSKGKRGGHSSVSTESESSSFHSS 423
            |||||||||||||||||||||||||||
Mouse   333 LKILSKGKRGGHSSVSTESESSSFHSS 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CXCR4	NP_001334985.1	CXCR4_N	77..109	CDD:314911	25/31 (81%)
		7tmA_CXCR4	110..384	CDD:320307	252/278 (91%)
		TM helix 1	110..137	CDD:320307	25/26 (96%)
		TM helix 2	144..169	CDD:320307	24/24 (100%)
		TM helix 3	180..210	CDD:320307	28/29 (97%)
		TM helix 4	222..244	CDD:320307	20/21 (95%)
		TM helix 5	267..296	CDD:320307	26/28 (93%)
		TM helix 6	303..333	CDD:320307	28/29 (97%)
		TM helix 7	352..377	CDD:320307	24/24 (100%)
Cxcr4	NP_034041.2	Important for chemokine binding and signaling. /evidence=ECO:0000250	1..23		12/14 (86%)
		CXCR4_N	8..40	CDD:288925	25/31 (81%)
		7tm_1	57..309	CDD:278431	227/251 (90%)
		Chemokine binding. /evidence=ECO:0000250	96..99		2/2 (100%)
		Chemokine binding. /evidence=ECO:0000250	115..119		2/3 (67%)
		Important for signaling. /evidence=ECO:0000250	135..137		1/1 (100%)
		Involved in dimerization, when bound to chemokine. /evidence=ECO:0000250	137..149		11/11 (100%)
		Chemokine binding, important for signaling. /evidence=ECO:0000250	193..197		3/3 (100%)
		Involved in dimerization. /evidence=ECO:0000250	198..217		15/18 (83%)
		Involved in dimerization. /evidence=ECO:0000250	273..275		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..359		23/23 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972768
Domainoid	1	1.000	472	1.000	Domainoid score	I8668
eggNOG	1	0.900	-	-		E33208_3BDN4
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20739
Inparanoid	1	1.050	650	1.000	Inparanoid score	I9914
Isobase	1	0.950	-	0	Normalized mean entropy	S6634
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43195
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009338
OrthoInspector	1	1.000	-	-		oto113331
orthoMCL	1	0.900	-	-		OOG6_117525
Panther	1	1.100	-	-	LDO	PTHR10489
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9980
SonicParanoid	1	1.000	-	-		X7072
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.240