back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL1R2 and Toll-6

DIOPT Version :9

Sequence 1:	XP_011510103.1	Gene:	IL1R2 / 7850	HGNCID:	5994	Length:	441	Species:	Homo sapiens
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	81/404 - (20%)
Similarity:	127/404 - (31%)	Gaps:	166/404 - (41%)

- Green bases have known domain annotations that are detailed below.

Human    43 AMLRLYVLVMGVSAFTLQPAA----HTGAARSCRFRGRHYKREFRLEGE-----PVALRCPQVPY 98
            |:..||||    |..:|...|    |..|.|:|     ...::..|.|.     |:|||
  Fly   467 ALNGLYVL----SLLSLDNNALIGVHPDAFRNC-----SALQDLNLNGNQLKTVPLALR------ 516

Human    99 WLWASVSPRINLTWHKNDSARTVP-GEEETRMWAQDGALWLLPALQEDS--------------GT 148
                      |:.     ..|||. ||.             :..:.|||              |.
  Fly   517 ----------NMR-----HLRTVDLGEN-------------MITVMEDSAFKGLGNLYGLRLIGN 553

Human   149 YVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVC-PDLSEFTRDKTDVKIQW 212
            |:           .:|.:..|.:    ||.:   |||.|:.:.:.|. |...|.|.....|::
  Fly   554 YL-----------ENITMHTFRD----LPNL---QILNLARNRIAVVEPGAFEMTSSIQAVRL-- 598

Human   213 YKDSLLLDKDNEKFLSVRGTTHLLVHDVALE--DAGYYRCVLTF--AHEGQQYNITRSIELRIKK 273
              |...|:..|..|.::.....|.:.|..||  |.|:....|.:  .|:.:..:::....|. .:
  Fly   599 --DGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLD-SE 660

Human   274 KKEETIPVIISPLKTISASLGSRLTIPCKV---FLGTGTPLTTMLWWTANDTHIESAYPGGRVTE 335
            .|.:|:.|..:.|:.|..|     :||..:   ||              ||..|.:..|
  Fly   661 LKLQTLDVSFNQLQRIGPS-----SIPNSIELLFL--------------NDNLITTVDP------ 700

Human   336 GPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPL 400
                :...:..|...|.|..:.:|              ||..::||               :.|
  Fly   701 ----DTFMHKTNLTRVDLYANQIT--------------TLDIKSLR---------------ILP- 731

Human   401 SLAFLVLGGIWMHR 414
                     :|.||
  Fly   732 ---------VWEHR 736

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.