Protein Alignment PAX8 and toy

DIOPT Version :10

• Sequence 1: NP_003457.1
• Gene: PAX8 / 7849
• HGNCID: 8622
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 181/531 - (34%)
• Similarity: 246/531 - (46%)
• Gaps: 138/531 - (25%)

Human     2 PHNSI---------RSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGC 57
            ||:|:         .:||.|:|||||.:|||||||:..||:||:|||.|.|||||||.|:||:||
  Fly    13 PHSSVGQSTLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGC 77

Human    58 VSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTV 122
            ||||||||||||||:|..||||||:|||..||:||.||||:.|::||||||||||:|.||::|.:
  Fly    78 VSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNI 142

Human   123 PSVSSINRIIRT----KVQQP-------------FN--------LPMDSCVATKSLSPGHTLIPS 162
            ||||||||::|.    |.||.             ||        .|.::..|..:|.|.     :
  Fly   143 PSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPA-----A 202

Human   163 SAVTPPE--SPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQS------SSSG- 218
            |.||.|.  |.|:|               :....||::..|.:.|...|.||.|      :|||
  Fly   203 SVVTSPANLSGQAD---------------RDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGD 252

Human   219 ---------PRKHLRT-DAFSQHHLEPLECPFERQHYPEAYASP--------------------- 252
                     .||..|. .:||...::.||..|||.|||:.:|..
  Fly   253 EDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRR 317

Human   253 SHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSS 317
            :..:.|:.:........|: ||....:.:|.|.|...|:           |.......||.:.:|
  Fly   318 AKWRREEKMRTQRRSADTV-DGSGRTSTANNPSGTTASS-----------SVATSNNSTPGIVNS 370

Human   318 SSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIP-TS 381
            :...:..:|||.:.           |:.|.|::......|:|..:......|.|....|.:| .|
  Fly   371 AINVAERTSSALVS-----------NSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNS 424

Human   382 GQGSYASS---AIAGMVAGSEYSGNAYGHTP-----YSSYSEAWRFPNSSLLSSPY----YYSST 434
            |..:..||   .||.|  ...|:.:....||     ..:|...:..|.|  |.|||    :.::.
  Fly   425 GFNTMYSSIPQPIATM--AENYNSSLGSMTPSCLQQRDAYPYMFHDPLS--LGSPYVSAHHRNTA 485

Human   435 SRPSA----PP 441
            ..|||    ||
  Fly   486 CNPSAAHQQPP 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX8	NP_003457.1	PAX	9..133	CDD:128645	90/123 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..222		19/80 (24%)
		Pax2_C	337..449	CDD:463563	31/122 (25%)
toy	NP_001368990.1	PAX	29..153	CDD:128645	90/123 (73%)
		COG5576	<253..368	CDD:227863	25/126 (20%)
		Homeodomain	267..322	CDD:459649	12/54 (22%)