Protein Alignment PAX8 and sv

DIOPT Version :10

• Sequence 1: NP_003457.1
• Gene: PAX8 / 7849
• HGNCID: 8622
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_524633.3
• Gene: sv / 43825
• FlyBaseID: FBgn0005561
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 688
• Identity: 211/688 - (30%)
• Similarity: 263/688 - (38%)
• Gaps: 271/688 - (39%)

Human     3 HNSIRS----GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG 63
            |:|..|    ||||:|||||.||||||||:|||||||:|||.||||||||||||||||||||||.
  Fly   165 HSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILS 229

Human    64 RYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSI 128
            |||||||.:.|||||||||||||.||:.|.:|||:||||||||||||||||.:|..|.|||||||
  Fly   230 RYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSI 294

Human   129 NRIIRTKV----------QQPFNLPMDSCVATKSLSPGHTLIPS-----SAVTPPESPQSDS--- 175
            |||:|.|.          ||..        .::||..||....|     ..:..|:.|.|:|
  Fly   295 NRIVRNKAAEKAKHVHHHQQHH--------VSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSAN 351

Human   176 ----------------------------------------LGST-------YSINGLLGIAQPG- 192
                                                    :.||       |||||:||| |.|
  Fly   352 SVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGI-QHGH 415

Human   193 -------------------SDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQ-------- 230
                               |.|||..::..::...:|.| .:..|.|:.:.|.:..|
  Fly   416 HSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHS-DNDDGKRQRMSTYSGDQLYTNIWSG 479

Human   231 -------HHL---------EPLECPFERQHYPEA------------------------YASPSHT 255
                   |.|         ....||   ..|.||                        |.|.:..
  Fly   480 KWCIKDDHKLLAELGNLTASTGNCP---ATYYEASNGFSTTPISGSGATASGNDTSMLYDSITTI 541

Human   256 KGEQGLYPLPLLNSTLDDGKATLTP------SNTPLGRNLSTHQTYPVVADPHSPF--------- 305
            ...|.....|.:..::  |..:|||      ....|..|....||.|       ||
  Fly   542 SQTQSSIYTPAIGPSI--GTGSLTPLVPISMHEMKLSANSIQEQTVP-------PFYTALAFDGN 597

Human   306 ------------AIKQE---TPEVSSSSSTPSSLSSSAFLDLQQVGS-----------GVPPFN- 343
                        .:.||   .|| ||.|:|...:|:....|:.:..|           |....|
  Fly   598 YTSMTSLENCSSLVGQEHIVMPE-SSDSNTLCPISTRIVPDITETNSTRVKEPLTNSDGCSEDNN 661

Human   344 ----------AFPHAASVYGQFTGQALLSGREMVGPTLPGYP----PHIPTSGQ----------- 383
                      :..|.||.:....|:..|.|..........:|    |..|:.|.
  Fly   662 KEPEKSNSSQSSDHIASPHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSGGSSLLNINPSENR 726

Human   384 -----------GSYA-----------SSAIAGMVAGSEYS--------GNAYGHTPYSSYSEAWR 418
                       |.|:           |:..:.:|.||:|:        |.|||...|.:
  Fly   727 SDVELNLSNNVGLYSTPTVLPSFNHYSAGCSSVVPGSDYAYNPAYTQYGGAYGSYGYGT------ 785

Human   419 FPNSSLLSSPYYYSS--TSRPSA----PPTTATAFDHL 450
              .|.|::|.|||.|  |..|..    .|..||..:.|
  Fly   786 --GSGLINSSYYYESGQTQSPLTHDLRSPLVATRANSL 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX8	NP_003457.1	PAX	9..133	CDD:128645	103/123 (84%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		49/55 (89%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		35/47 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..222		25/137 (18%)
		Pax2_C	337..449	CDD:463563	37/184 (20%)
sv	NP_524633.3	PAX	175..299	CDD:128645	103/123 (84%)