DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAX8 and ey

DIOPT Version :9

Sequence 1:	NP_003457.1	Gene:	PAX8 / 7849	HGNCID:	8622	Length:	450	Species:	Homo sapiens
Sequence 2:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	143/362 - (39%)
Similarity:	180/362 - (49%)	Gaps:	73/362 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    10 HGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPG 74
            |.|:|||||.||.|||||:..||:||:|||.|.|||||||.|:||:||||||||||||||||||.
  Fly    98 HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPR 162

Human    75 VIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQP 139
            .||||||:|||.:||.||..|||:.|::||||||||||.|.||.||.:||||||||::|....|.
  Fly   163 AIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQK 227

Human   140 FNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQD 204
            ......|  .:.|.|.|:::....:|               ||.|  .::...|..|....|..|
  Fly   228 EQQSTGS--GSSSTSAGNSISAKVSV---------------SIGG--NVSNVASGSRGTLSSSTD 273

Human   205 SCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQ-GLY-PLPLL 267
            ..:.:....||.||.                              ||.|....|| .:| .|.||
  Fly   274 LMQTATPLNSSESGG------------------------------ASNSGEGSEQEAIYEKLRLL 308

Human   268 NSTLDDGKATLTPSN-TPL----GRNLSTHQTYP-VVADPHSPFAIKQE---TPEVSSSSSTPSS 323
            |:....|...|.|:. .||    ..:|.|..::| :|...|......|:   .|...|.|..|:|
  Fly   309 NTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTS 373

Human   324 LSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL 360
            ||..             |.::.|:.|||....:|.:|
  Fly   374 LSEI-------------PISSAPNIASVTAYASGPSL 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAX8	NP_003457.1	PAX	9..133	CDD:128645	90/122 (74%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	87..135		32/47 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..222		12/62 (19%)
		Pax2_C	337..448	CDD:315141	7/24 (29%)
ey	NP_001014693.1	PAX	98..221	CDD:128645	90/122 (74%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010