Protein Alignment PAX8 and eyg

DIOPT Version :10

• Sequence 1: NP_003457.1
• Gene: PAX8 / 7849
• HGNCID: 8622
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_524042.2
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 448
• Identity: 131/448 - (29%)
• Similarity: 185/448 - (41%)
• Gaps: 111/448 - (24%)

Human     6 IRSGHGGLNQLGG-----AFVNGRPLPEVVRQ-RIVDLAH-QGVRPCDISRQLRVSHGCVSKILG 63
            |..|.||....||     ....|..|..::.| |:::.:. .|:|..||::.:....|.|||:|
  Fly    88 IPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSKLL- 151

Human    64 RYYETGSIR-PGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSS 127
                 ||:| ||:|||||||||||.||.||..|||:|||:||||||:||::||||.|.|.|||||
  Fly   152 -----GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSS 211

Human   128 INRIIRTKVQQPFNLPMDSCVATKSL---------SPGHTL----------IPSSAVTPPESPQS 173
            ||||:|.:..:.        |||:..         .|.|..          :|.....||..|.|
  Fly   212 INRILRNRAAER--------VATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPS 268

Human   174 --------------------------DSLGSTYSINGLLG------IAQPGSDKRKMDDSDQDSC 206
                                      .||.|.:.:.|..|      ...|||......:|..::.
  Fly   269 ALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENR 333

Human   207 RLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYP-----EAYASPSHTKGEQGLYPLPL 266
            .:..|.......|:.......||...||.||..|::.|||     |..:|
  Fly   334 HIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSS--------------- 383

Human   267 LNSTLDDGKATLTPSNTPLGRNLSTHQTYPVV----ADPHSPFAIKQETPEVSSSSSTPSSLSSS 327
             .::|.:.:..:..||.  ......||...::    :.|.:|.. .|::.:..:||.|||:.||:
  Fly   384 -RTSLSEARVQVWFSNR--RAKWRRHQRMNLLKRQRSSPANPLH-SQQSNDAPASSPTPSNHSSA 444

Human   328 AFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPG-----YPPHIPT 380
            :  ....|....||....|.......|....::|. ..:.||  ||     :|.|:||
  Fly   445 S--TSAPVAPVPPPQQPLPLCGDHSPQGPPPSVLL-HPLHGP--PGGHHHHHPLHLPT 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX8	NP_003457.1	PAX	9..133	CDD:128645	67/131 (51%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		16/62 (26%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		34/47 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..222		16/104 (15%)
		Pax2_C	337..449	CDD:463563	13/49 (27%)
eyg	NP_524042.2	HTH_ARSR	120..217	CDD:481197	59/102 (58%)
		Homeodomain	349..405	CDD:459649	15/73 (21%)