Protein Alignment PAX8 and toe

DIOPT Version :10

• Sequence 1: NP_003457.1
• Gene: PAX8 / 7849
• HGNCID: 8622
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 147/542 - (27%)
• Similarity: 207/542 - (38%)
• Gaps: 176/542 - (32%)

Human    16 LGGAFVNGRP-------------LPEVVRQ-RIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYY 66
            |||.|..|..             |..:..| |:::|:..|:|..|:::.:....|.|||:|
  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL---- 164

Human    67 ETGSIR-PGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINR 130
              |::| ||:|||||||||||.||.||..|||:|||:||||||:||:.||||.|.|.||||||||
  Fly   165 --GTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINR 227

Human   131 IIRTKVQQPFNLPMDSCVATKSLSPGHTLIPS------------------SAV---TPP------ 168
            |:|.:..:     ..:....::.|.|:.:.|:                  .||   |||
  Fly   228 ILRNRAAE-----RAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAG 287

Human   169 --ESPQSDSLGSTYSINGLLGIAQPGSDKRK--------------MDDSDQDSCRLSIDSQSSSS 217
              .:.|....||:|..:|.:. :.|.|....              ..||...|.|||:.:.|..|
  Fly   288 AGGALQPGGSGSSYGSDGNMS-SNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDS 351

Human   218 GPRKHLRTDA-----------------------------FSQHHLEPLECPFERQHYP------- 246
            |.|.....||                             ||...|:.||..|::.|||
  Fly   352 GSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREK 416

Human   247 --------EAYA------------------------SPSHTKGEQGLYPLPLLNSTLDDGKATLT 279
                    ||..                        |||.:..     |.||:|..:........
  Fly   417 LAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSS-----PTPLVNPVVSPVSPIPV 476

Human   280 PSNTPLGRNLSTHQTYPV----VADPHSPFAIKQETPEV---SSSSSTPSSLSSSAFLDLQQVGS 337
            |....:..:....|.||.    :.:..|..:..|....:   |..||..||:||:..::
  Fly   477 PVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHME------ 535

Human   338 GVPPFNAFPHAASVYGQFTGQALLS-GRE-----MVGPTLPGYPPHIPTSGQGSYASSAIAGMVA 396
                   .|.||......|..|.|| |.|     .:..||| .|..:||:...::|.|.....:|
  Fly   536 -------EPAAAVATASPTASAPLSMGGENSAFRALPMTLP-MPMTLPTASAAAFALSFARQYIA 592

Human   397 GSEYSGN----AYGHTPYSSYS 414
              :|.|.    .:|.:|..:.|
  Fly   593 --KYMGTPLNLGHGSSPIQAQS 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX8	NP_003457.1	PAX	9..133	CDD:128645	65/131 (50%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		17/65 (26%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		34/47 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..222		23/105 (22%)
		Pax2_C	337..449	CDD:463563	23/88 (26%)
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197	58/101 (57%)
		Homeodomain	385..441	CDD:459649	11/55 (20%)