Protein Alignment PAX8 and Poxn

DIOPT Version :10

• Sequence 1: NP_003457.1
• Gene: PAX8 / 7849
• HGNCID: 8622
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_476686.1
• Gene: Poxn / 36741
• FlyBaseID: FBgn0003130
• Length: 425
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 164/483 - (33%)
• Similarity: 212/483 - (43%)
• Gaps: 126/483 - (26%)

Human     1 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRY 65
            |||    :|..|:|||||.||||||||:.||:||||||..|||||||||||.||||||||||.|:
  Fly     1 MPH----TGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRF 61

Human    66 YETGSIRPGVIGGSKPK-VATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSIN 129
            |||||||||.|||||.| ||||.||:||...|.:|..|||||||::|..:.|||..:|||:||||
  Fly    62 YETGSIRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSIN 126

Human   130 RIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSD 194
            ||:|..     .|..|...:::.        .::|.....:..:...||..| ||..|.|.|
  Fly   127 RILRNS-----GLWTDEMTSSQQ--------NAAAAAAAAAAAAHQAGSGPS-NGYGGQAPP--- 174

Human   195 KRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASP----SHT 255
                              ...:..|.....|.:.::                  ||.|    .::
  Fly   175 ------------------PPVTVAPPTPAATPSIAR------------------YAKPPALMMNS 203

Human   256 KGEQGLYPLPLLNSTLDDGKA-TLTPSNTPLGRNLST---HQTYPVVADPHSPFAIKQETPEVSS 316
            .||..:.|.|.:..::..|.: .|.|:.:.|..:.|.   |..:
  Fly   204 AGEMPIKPAPKMPPSMGHGHSHGLNPNVSGLDLSYSALHKHWLW--------------------- 247

Human   317 SSSTPSSL-SSSAFLDLQQVGSG---VPPFNAF-PHA--------ASVYGQFTGQALLSGREMVG 368
               .||.| .:.|.:..|...||   :|....: |||        .|..|.||...  |..::..
  Fly   248 ---NPSLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMAAAAASSTSALGGFTKSE--SSIDLST 307

Human   369 PTLPGYPPHIPTSGQGSYASSAI----AGMVAGS--EYS-GNAYGHT----PYSSYSEAWRFPNS 422
            |...|.......||:.|.|:.::    .|..|||  |.| |:...|:    || |..|..:.|..
  Fly   308 PGAAGDALSDCDSGKSSPAALSLTASGGGNGAGSAPEASPGSTLSHSRKRNPY-SIEELLKKPEK 371

Human   423 SL---------LSSPYYYSSTSRPSAPP 441
            .|         |.|....||...|.|||
  Fly   372 RLRLDSNRLECLESSSCESSQDSPVAPP 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAX8	NP_003457.1	PAX	9..133	CDD:128645	90/124 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		27/47 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..222		10/62 (16%)
		Pax2_C	337..449	CDD:463563	39/137 (28%)
Poxn	NP_476686.1	HTH_ARSR	5..133	CDD:481197	91/132 (69%)