DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PXDN and CG42331

DIOPT Version :10

Sequence 1:NP_036425.1 Gene:PXDN / 7837 HGNCID:14966 Length:1479 Species:Homo sapiens
Sequence 2:NP_651282.2 Gene:CG42331 / 42948 FlyBaseID:FBgn0259233 Length:1615 Species:Drosophila melanogaster


Alignment Length:873 Identity:286/873 - (32%)
Similarity:388/873 - (44%) Gaps:171/873 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   614 PDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYP------RDPYTVEQ 672
            |::.|||..                       |.|:.|.:   :|:.|..|      |:......
  Fly    93 PEMLRNGQT-----------------------LQDNHPAA---MLSRFNAPTTDSERREMAAYAT 131

Human   673 ARAGEIFERTLQLIQE--HVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDM 735
            ..|.:.|.:..|.|.|  ...|...:.|..|:                 |.|....|....|  |
  Fly   132 IAAAKAFRKNFQHIDELARQSHTQRISLRRTA-----------------LEGLCPPRDPPPC--M 177

Human   736 CFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVST 800
            ...::||||||||||.:.|.|||:...|.|.|...|.:|.:|.|.     ..:|..|...|.||.
  Fly   178 PASERYRTHDGTCNNKRRPRWGAAQMPFNRFLPPEYGDGVDTVRS-----SADGSTLSSSRFVSL 237

Human   801 TLIGT-ETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQ--HCSNVCSNDPPCFSVMI 862
            .:.|. |...|   .|.|:.||||.||||:.||    :|.|..:|.  .|.......|.||.:.:
  Fly   238 LVHGAREGEAP---LTLMIAQWGQMLDHDMTST----AQPRSINGSIPSCCGGKDFHPACFPIKV 295

Human   863 PPNDS-RARSGARCMFFVRSSPV----CGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHE 922
            |.:|. .|....||:.|:||:|.    |....          |||.||:|||||||.:|.::...
  Fly   296 PLDDPWLAPLKVRCLEFLRSAPAQRRDCVLSW----------REQTNQVTSYIDASPIYSNSAKS 350

Human   923 ARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSM 987
            :.:.|       :.|.|        ||.:..|.|.|.:.........|..:||.|:.||.||.:|
  Fly   351 SDNAR-------VFRHG--------LLVYGRGDPAEDVCQRGAIATKCIRSGDGRSGEQPGLLAM 400

Human   988 HTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILG-------EVGMR 1045
            |.:|..||||||.||.:|||||..:.:|.|||:||||..||||::.:||.|||       ::.:.
  Fly   401 HHVWVGEHNRIAMELSELNPHWSDEKVYQETRRIVGAMFQHITFREFLPVILGREVVKLFDLELM 465

Human  1046 TLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFFSPFRIVN 1110
            ..|.|..|...:|..:.||||.|||||||:||.....|.|.:.. :..:::.||:. |....|.:
  Fly   466 PSGYYERYSSKVNPTVANAFAAAAFRFGHSLVQNSYTRCDRHHN-VINNNVSLHEE-FQRGDIGS 528

Human  1111 EGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLF-SMAHTVALDLAAINIQRGRDHGIPPYHDYR 1174
            .|.:..|||||.......|  .:.:..|||..|| :......||||||||||||||||.||..:|
  Fly   529 AGSLHRLLRGLASQRALKR--DEFITPELTNHLFQTPGFPFGLDLAAINIQRGRDHGIAPYSAWR 591

Human  1175 VYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQ 1239
            |.|.||...:::|..| :..||..:::...|.|..:||||...:.|..|.|..:|||..|:::.|
  Fly   592 VPCGLSPILSWDDFAN-VVGPESAKRIGHAYRSVHDIDLFVGGIAERPVVGGLVGPTFACIIAQQ 655

Human  1240 FKRLRDGDRLWYENPGV---FSPAQLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPH----- 1296
            |...|.|||.||||.|.   |:||||..:::.|||::||......| :|..:|..|||..     
  Fly   656 FSNSRRGDRFWYENGGFESSFTPAQLHSLRRVSLAQVLCRTVGGGT-LQPHIFIPAEFEDNERQT 719

Human  1297 -GYGSCDEIPRVDLRVW--------QDCCEDCRTRGQFNAFSYHFRGRRSLEFSYQEDKP--TKK 1350
             |.||   :..:||..|        |...|...|.||....|...         .:|||.  :.:
  Fly   720 CGVGS---LSPIDLSPWLEQDPFHNQQVPEQVFTIGQPELGSVQI---------IKEDKAGFSNR 772

Human  1351 TRPRKIPSVGRQGEHLSNSTSAFSTRSDASGTN-----DFREFVLEMQKTITDLRTQIKK--LES 1408
            .:|.| |.|    |...:|.|.|...::.:.|.     |.|      :||:|      ||  ..:
  Fly   773 VKPIK-PQV----EVSPSSLSGFHRPTNENLTKVSDKLDLR------RKTVT------KKNNTNN 820

Human  1409 RLSTTECVDAGGESHANNTKWKKDACTI 1436
            |..||. ...||   .||...|....|:
  Fly   821 RQQTTR-KPVGG---VNNKLDKSPKITL 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PXDNNP_036425.1 leucine-rich repeat 45..63 CDD:275380
LRR 1. /evidence=ECO:0000255 61..84
leucine-rich repeat 66..87 CDD:275380
LRR 2. /evidence=ECO:0000255 85..108
LRR <97..>215 CDD:443914
LRR 3. /evidence=ECO:0000255 110..132
leucine-rich repeat 112..135 CDD:275378
LRR 4. /evidence=ECO:0000255 133..156
leucine-rich repeat 136..159 CDD:275378
LRR 5. /evidence=ECO:0000255 157..180
leucine-rich repeat 160..183 CDD:275378
LRR 6. /evidence=ECO:0000255 182..204
leucine-rich repeat 184..196 CDD:275378
LRRCT 192..243 CDD:214507
I-set 246..333 CDD:400151
Ig strand B 263..267 CDD:409490
Ig strand C 276..280 CDD:409490
Ig strand F 314..319 CDD:409490
Ig strand G 328..331 CDD:409490
I-set 342..429 CDD:400151
Ig strand B 359..363 CDD:409544
Ig strand C 372..376 CDD:409544
Ig strand E 395..399 CDD:409544
Ig strand F 409..414 CDD:409544
Ig strand G 422..425 CDD:409544
Ig3_Peroxidasin 446..519 CDD:143222
Ig strand B 450..454 CDD:143222
Ig strand C 463..467 CDD:143222
Ig strand E 485..489 CDD:143222
Ig strand F 499..504 CDD:143222
Ig strand G 513..516 CDD:143222
Ig4_Peroxidasin 542..610 CDD:143223
Ig strand B 542..546 CDD:143223
Ig strand C 555..559 CDD:143223
Ig strand E 577..581 CDD:143223
Ig strand F 591..596 CDD:143223
Ig strand G 605..608 CDD:143223
peroxidasin_like 864..1303 CDD:188658 176/460 (38%)
LRR 7. /evidence=ECO:0000255 1151..1175 18/23 (78%)
LRR 8. /evidence=ECO:0000255 1270..1291 7/20 (35%)
Required in homotrimerization. /evidence=ECO:0000269|PubMed:31295557 1315..1411 25/104 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1342..1380 11/39 (28%)
VWC 1415..1470 CDD:214564 6/22 (27%)
CG42331NP_651282.2 An_peroxidase 183..707 CDD:460804 218/566 (39%)
LHP1 731..>871 CDD:227520 35/144 (24%)
Blue background indicates that the domain is not in the aligned region.

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