DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PXDN and cd

DIOPT Version :9

Sequence 1:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens
Sequence 2:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	905	Identity:	276/905 - (30%)
Similarity:	405/905 - (44%)	Gaps:	217/905 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITW--------NKDGVQVTES-----GKFHISPE 576
            |.|..:.:.:..|:..|..||      .|||..|        :.||.|...:     |...|..|
  Fly    80 PSFFFVVNGSDSELAPNRPLP------DEPAAEWALQQAALGHHDGAQAVSAGIKALGDREILEE 138

Human   577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPD---VSRNGDPFVATSIVEAIATVDRA 638
            | |..|:|.......|..::.|               |:   ::|.|       .||..||:
  Fly   139 G-LQPNEVNTPSFRHYRSLSTN---------------PEARKLARRG-------YVENQATI--- 177

Human   639 INSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSY 703
                             |:...|.|.:.|.                  :.::..|..:
  Fly   178 -----------------DIAKRFNYTKQPG------------------RSNIGWGPKI------- 200

Human   704 HYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHP-MWGASLTAFERLL 767
               .|..|..|.|              .|.   |:.:||...|.|||.||| .:|||:..:.|::
  Fly   201 ---VLPDPTVLRL--------------ECD---FNARYRRSTGVCNNKQHPRTYGASMVPYRRMV 245

Human   768 KSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDST 832
            ...|.:|...|| ::.|     ..||..|.||.. |...:...|..||.||..:|||:|||:.:|
  Fly   246 SPDYADGIAAPR-VSHH-----GRLPPARQVSLK-IHRSSYETDSNFTVMLAVFGQFMDHDITAT 303

Human   833 VVALSQARFSDGQ--HCSNVCSND--PPCFSVMIPPNDSRARS-GARCMFFVRSSPVCGSGMTSL 892
            .:..||    :|:  .|....:.:  |.|:.|.|.|:|...:. ...||.||||:| ..:|...
  Fly   304 SLTTSQ----EGESIDCCVAATREQHPECYPVDILPDDPYYKQYNISCMNFVRSAP-APTGRFG- 362

Human   893 LMNSVYPREQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPT 957
                  ||.|:||.|::||||.|||:.|.....:|...:  |.||. .|...|:.|||.::.|..
  Fly   363 ------PRMQLNQATAFIDASVVYGNLEQRQNQLRSFIN--GSLRM-FVTDDGRQLLPISSNPAD 418

Human   958 ECMRDE-NESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKI 1021
            .|.|.: ......||.:||.||||.|.|||||.||.|.||.:|.:|.:.||||:.:.:|.|.|||
  Fly   419 GCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKI 483

Human  1022 VGAEIQHITYQHWLPKILGEVGMRTLGEYHG-------------YDPGINAGIFNAFATAAFRFG 1073
            :||::.||||..:||.:||    :.:.|..|             |||.::..|.|.||.|||||.
  Fly   484 LGAQMAHITYNEFLPVLLG----KNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFA 544

Human  1074 HTLVNPLLYRLD-ENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGK--MRVPSQLL 1135
            |||: |.|:.:. :|..|.|   :.|||..|:||.:..|.|||   ..|...|..  |:| .:..
  Fly   545 HTLL-PGLFNISRDNSTPEA---IELHKMLFNPFSLWAEHGID---HALMTAANTPVMQV-DRFF 601

Human  1136 NTELTERLF-----SMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNP 1195
            :.|:|::||     .......|||.::|||||||||||.|..:|.:|.|....|:|::...|.|.
  Fly   602 SLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAIDNA 666

Human  1196 EIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYE---NPGVF 1257
            .: :.::::|.|..::|::...:.|..:.|:..||.|.|::|.||.||:.||..|||   .|..|
  Fly   667 TL-DSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKF 730

Human  1258 SPAQLTQIKQTSLARILCDNADNITRVQSDVF-RVAEFPHGYGSCDEIPRVDLRVWQDCCEDCRT 1321
            :.|||.:|.:||||.|:|.|:|.||||:..|. |:.:..:        |.||       |:|
  Fly   731 TKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGN--------PHVD-------CQD--- 777

Human  1322 RGQFNAFSYHFRGRRSLEFSYQEDKP-TKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDAS 1380
               ...|.::|             :| ::|.:|:.:.|.|     :|..:::....|.|:
  Fly   778 ---LEGFHFNF-------------EPWSEKQQPQDLHSAG-----ISRGSTSVRVMSKAN 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		LRR 1	87..108
		LRR_4	110..151	CDD:289563
		LRR_8	111..170	CDD:290566
		LRR 2	111..132
		leucine-rich repeat	112..135	CDD:275378
		LRR_4	135..175	CDD:289563
		LRR 3	135..156
		leucine-rich repeat	136..159	CDD:275378
		LRR_8	158..>195	CDD:290566
		LRR 4	159..180
		leucine-rich repeat	160..183	CDD:275378
		leucine-rich repeat	184..196	CDD:275378
		TPKR_C2	192..243	CDD:301599
		Ig	246..333	CDD:299845
		I-set	246..333	CDD:254352
		I-set	342..429	CDD:254352
		Ig	346..429	CDD:299845
		I-set	433..519	CDD:254352
		Ig3_Peroxidasin	446..519	CDD:143222
		I-set	525..611	CDD:254352	22/98 (22%)
		Ig4_Peroxidasin	542..610	CDD:143223	18/80 (23%)
		An_peroxidase	741..1282	CDD:281139	215/571 (38%)
		peroxidasin_like	864..1303	CDD:188658	177/465 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380		7/38 (18%)
		VWC	1415..1470	CDD:214564
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	215/571 (38%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	158/401 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820