DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PXDN and Pxt

DIOPT Version :9

Sequence 1:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens
Sequence 2:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	851	Identity:	256/851 - (30%)
Similarity:	384/851 - (45%)	Gaps:	174/851 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   530 IPSDTTVEVGANVQLPC----SSQGEPE----PAITWNKDGVQVTESGKFHISPE---------- 576
            :|....:.....:|.|.    .|..:|:    ||   .|.| ...|:|:.|.:|:
  Fly    65 LPCSDGIRCVPQIQCPAHVRMESHEKPQICDLPA---GKFG-YCCETGQNHTAPKPETSPKERRS 125

Human   577 GFLTINDVGPADAGRYECVARN----TIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDR 637
            ||.||......|..|     ||    ..|.|.:.:          |.|.|..|..:|
  Fly   126 GFPTILSPAVLDEAR-----RNFEHLMHGVAQIPV----------RRGFPDFAHGLV-------- 167

Human   638 AINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQL-IQEHVQHGLMVDLNGT 701
                     |.|..:..     |..:......:||....::|.:..|: :::.:.:.:.:....|
  Fly   168 ---------FHSTAKDD-----LHNFAISNSAIEQVMTTQLFGKKEQVPVEDFITNNVPIKFTET 218

Human   702 SYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNN--LQHPMWGASLTAFE 764
            ...::....|.          |...|.|           ||:.||||||  .|..:|||:....|
  Fly   219 PLAHHCQPPPV----------CGNIRSV-----------YRSMDGTCNNPEPQRSLWGAAGQPME 262

Human   765 RLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDL 829
            |:|...||:|..|||..:.    :|..|...|.:|.||: ::...|..::..|:||:||.|.||:
  Fly   263 RMLPPAYEDGIWTPRAHSS----DGTPLLGARKISRTLL-SDVDRPHPKYNLMVMQFGQVLAHDI 322

Human   830 DSTVVALSQARFSDG---QHCS--NVCSNDP-----PCFSVMIPPNDS-RARSGARCMFFVR--- 880
            ..|    |..|..||   |.||  ...:..|     .|..:.:.|:|. .:..|.||:.|||
  Fly   323 SQT----SSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSL 383

Human   881 -SSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRS 944
             .||.|          .:...:|:.::|.::|||.||||::..:||:|  |...|.||  ::...
  Fly   384 VPSPDC----------QLSYGKQLTKVTHFVDASPVYGSSDEASRSLR--AFRGGRLR--MMNDF 434

Human   945 GKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHW 1009
            |:.|||. |.....|  ...|:...||.:||.|.|:.:.|.::..|..|||||:|..|.:|||..
  Fly   435 GRDLLPL-TNDKKAC--PSEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSA 496

Human  1010 DGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTL-------GEYHGYDPGINAGIFNAFAT 1067
            ..:|::.|.|:||.||:|||||..:||.|:|...|:..       |..|.|:..:|..|.|.|:.
  Fly   497 SDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSG 561

Human  1068 AAFRFGHTLVNPLLYRLDENFQPIAQDH------LPLHKAFFSPFRIVNEGGIDPLLRGLFGVAG 1126
            ||:|.||:.|       |..|| |.|:|      :.:....|:|.|:......|.:||.|:  :.
  Fly   562 AAYRMGHSSV-------DGKFQ-IRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLY--SQ 616

Human  1127 KMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNE 1191
            .|:.....::..|:..||...:...|||||||||||||.|:..|:||.........|:||..
  Fly   617 PMQQVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQF--- 678

Human  1192 IKNP-EIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYE--- 1252
               | ||.:||.|:|.:..:|||:...::|..|.|..:|.|...:::.||.|.:.|||.:||
  Fly   679 ---PIEIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDN 740

Human  1253 --NPGVFSPAQLTQIKQTSLARILCDNADNIT--RVQSDVFRVAEFPHGYGS----CDE--IPRV 1307
              |||.|:|.||.:|::.:|||:||||:|.:|  .|....|..|:.|   |:    ||:  :|.|
  Fly   741 GINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHP---GNQMIGCDDPNLPSV 802

Human  1308 DLRVWQ 1313
            :|..|:
  Fly   803 NLEAWR 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		LRR 1	87..108
		LRR_4	110..151	CDD:289563
		LRR_8	111..170	CDD:290566
		LRR 2	111..132
		leucine-rich repeat	112..135	CDD:275378
		LRR_4	135..175	CDD:289563
		LRR 3	135..156
		leucine-rich repeat	136..159	CDD:275378
		LRR_8	158..>195	CDD:290566
		LRR 4	159..180
		leucine-rich repeat	160..183	CDD:275378
		leucine-rich repeat	184..196	CDD:275378
		TPKR_C2	192..243	CDD:301599
		Ig	246..333	CDD:299845
		I-set	246..333	CDD:254352
		I-set	342..429	CDD:254352
		Ig	346..429	CDD:299845
		I-set	433..519	CDD:254352
		Ig3_Peroxidasin	446..519	CDD:143222
		I-set	525..611	CDD:254352	23/102 (23%)
		Ig4_Peroxidasin	542..610	CDD:143223	22/89 (25%)
		An_peroxidase	741..1282	CDD:281139	204/576 (35%)
		peroxidasin_like	864..1303	CDD:188658	165/468 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380
		VWC	1415..1470	CDD:214564
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337	12/55 (22%)
		An_peroxidase	237..772	CDD:281139	204/576 (35%)
		peroxinectin_like	396..767	CDD:188655	144/393 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770