DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PXDN and cysu

DIOPT Version :9

Sequence 1:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens
Sequence 2:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster

Alignment Length:	728	Identity:	246/728 - (33%)
Similarity:	350/728 - (48%)	Gaps:	123/728 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   638 AINS----TRTHLFDSRPRS---PNDLLALFRYPRDPYTVEQARAGEI-------FERTLQLIQE 688
            |||:    .|..:..::|:|   |.:|               |..||:       ..||..|..|
  Fly    72 AINAAYLDARKRIHVAQPKSDWKPEEL---------------ATVGELLLDISIQLARTYGLSYE 121

Human   689 HVQHGL-MVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQ 752
            .::.|| .:|.:.|.  ..::..|.:..:                  .|...|||..||.|||::
  Fly   122 EIEKGLPTIDTSKTL--IREVCPPFFAGV------------------ECRPGKYRRFDGLCNNIE 166

Human   753 HPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTETVTPDEQF--- 814
            ||.|||:...|:||:..:|.:|.|.|| |:    ..|..||..|:||      .|:.||:.|
  Fly   167 HPTWGAANAPFQRLIGPLYSDGINAPR-IS----VTGRDLPFSRVVS------RTMHPDDGFHDH 220

Human   815 --THMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCS-----NDPPCFSVMIPPNDSRAR-S 871
              |.|::.||||:|||...|...|.....:|.:.|   |.     ..|.|..:.||.:|...| .
  Fly   221 AGTVMVIAWGQFMDHDFTLTGTPLDPINRNDPEEC---CKRPLHLKHPYCNEIRIPDDDYFYRLF 282

Human   872 GARCMFFVRS--SPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIRDLASHRG 934
            ..:|:.|||.  ||..|..:.|        |:|.|.||..|||:.|||..|..||.:|  ..:.|
  Fly   283 NVKCIDFVRGFPSPRPGCKLGS--------RQQFNTLTGVIDANTVYGVKESFARKLR--TGYGG 337

Human   935 LLRQG-IVQRSG-KPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNR 997
            |:|.. :.|..| |.|||.....|.|.....|:| :.||..|:.|.||||.||.||||..|||||
  Fly   338 LMRMNPVFQEYGLKDLLPLKLDIPDEGCTRPNKS-MYCFEGGEIRVNEQLVLTCMHTLMAREHNR 401

Human   998 IATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTL-------GEYHGYDP 1055
            :||.|.::|.|||.:|::.|.|:|..|.:||:|:..:||.:||:..|...       |.:.|||.
  Fly   402 LATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDS 466

Human  1056 GINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRG 1120
            .:|.||.::||.|||||||:|:...:.|..:..:.||...  |......|:.:...|.:|....|
  Fly   467 TVNPGIIDSFAGAAFRFGHSLLPTAVERWSKAHKFIASKR--LSDLIRRPYDLYRAGVLDEYFMG 529

Human  1121 LFG-VAGKMRVPSQLLNTELTERLFSM-AHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAH 1183
            |.. ||..|   ...:..|:|..||.. .....:||.:.|:||||:.|||.|.::|.:|.|..::
  Fly   530 LMNQVAQAM---DDSITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSN 591

Human  1184 TFEDLKNEIKNPEIREKLKRLYGSTL----NIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLR 1244
            |::::...:.|..:..     |||..    :|||:...|.|..:|||.||||..|:::||...||
  Fly   592 TWDEMYGSMPNETVLR-----YGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLR 651

Human  1245 DGDRLWYE---NPGVFSPAQLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYG---SCDE 1303
            .|||.|||   .|..|:|.||.:|::..|:|::|||.|.|..||  ::.:....|...   .|..
  Fly   652 RGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTVQ--IYPMVLPDHEINPRVPCKS 714

Human  1304 --IPRVDLRVWQD 1314
              ||.:||..|.|
  Fly   715 GIIPSIDLTKWAD 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		LRR 1	87..108
		LRR_4	110..151	CDD:289563
		LRR_8	111..170	CDD:290566
		LRR 2	111..132
		leucine-rich repeat	112..135	CDD:275378
		LRR_4	135..175	CDD:289563
		LRR 3	135..156
		leucine-rich repeat	136..159	CDD:275378
		LRR_8	158..>195	CDD:290566
		LRR 4	159..180
		leucine-rich repeat	160..183	CDD:275378
		leucine-rich repeat	184..196	CDD:275378
		TPKR_C2	192..243	CDD:301599
		Ig	246..333	CDD:299845
		I-set	246..333	CDD:254352
		I-set	342..429	CDD:254352
		Ig	346..429	CDD:299845
		I-set	433..519	CDD:254352
		Ig3_Peroxidasin	446..519	CDD:143222
		I-set	525..611	CDD:254352
		Ig4_Peroxidasin	542..610	CDD:143223
		An_peroxidase	741..1282	CDD:281139	213/571 (37%)
		peroxidasin_like	864..1303	CDD:188658	169/462 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380
		VWC	1415..1470	CDD:214564
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	213/571 (37%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	151/394 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750