DRSC/TRiP Functional Genomics Resources

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Protein Alignment PXDN and CG4009

DIOPT Version :9

Sequence 1:NP_036425.1 Gene:PXDN / 7837 HGNCID:14966 Length:1479 Species:Homo sapiens
Sequence 2:NP_001262655.1 Gene:CG4009 / 42054 FlyBaseID:FBgn0038469 Length:649 Species:Drosophila melanogaster


Alignment Length:742 Identity:217/742 - (29%)
Similarity:330/742 - (44%) Gaps:156/742 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   624 VATSIVE-AIAT------VDRAINSTRTHLFDSRPR-SPNDLLALFRYPRDPYTVEQARAGEIFE 680
            |..|::. |:||      ::.:::.::...||.||. |...|.|                     
  Fly     6 VVLSVLSVAVATKCPYSAMEPSLSRSKRSSFDIRPGVSDGSLDA--------------------- 49

Human   681 RTLQLIQEHVQHGLMVDLNGTSYHYNDLVSP----QYLNLIANLSGCTAHRRVNNCSDMCFHQKY 741
                ||:|     .|...||.:.| |....|    |.|.       |....|  ||.:...:..|
  Fly    50 ----LIKE-----FMPKYNGNNVH-NSWAEPSASQQPLR-------CGVPPR--NCLNDTRNLHY 95

Human   742 RTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTE 806
            ||.||:||||.:|.:|.:::.:.|||         .||.:        ...|..||:|.:|.|.:
  Fly    96 RTLDGSCNNLLYPEFGIAVSRYRRLL---------PPRQV--------EQAPNARLISLSLYGEQ 143

Human   807 TVTPDEQF-THMLMQWGQFLDHDLD--STVVALSQARFSDGQHCSNVCS--NDPPCFSVMIPPND 866
              |.:::| |...||||||:.||:.  ||..|        .|.|   |:  ..|.|..:.:|...
  Fly   144 --TRNDRFRTMAAMQWGQFVAHDISQLSTQGA--------PQDC---CAEPRHPRCLPINLPRGG 195

Human   867 SRA-RSGARCMFFVRS----SPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSI 926
            ..| .:|..|:.|.||    ..:|..      :....| |::...|:|:|.|::||:...:.|.:
  Fly   196 PIAYHTGKTCLHFARSVSDADAICPK------VEEPQP-EKLTVATAYLDLSSIYGNNPSQNRKV 253

Human   927 RDLASHRGLLRQGIVQRS---GKPLLPFATGPPTEC-MRDENESPIPCFLAGDHRANEQLGLTSM 987
            |       |.:.|:::.|   |:..||.:.....|| .:.|      |::..|.|......:..:
  Fly   254 R-------LFKGGLLKTSYTNGQHWLPVSQNENGECGAKSE------CYIVPDIRNRFSPTIALL 305

Human   988 HTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTLG---- 1048
            .||..|||||:|..|..:||....:.|:.|.|||..|:.|.|||..|||..:|.......|    
  Fly   306 QTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLFVGRTYTYLNGLIYP 370

Human  1049 ----EY-HGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFF----S 1104
                || :.||..:|...:..|:.||||:.||.: |..:.|   ..|..:.:..:..:.|    .
  Fly   371 VEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQI-PGWFSL---VAPNRRSNRTMRLSDFLDRTE 431

Human  1105 PFRIVN-EGGIDPLLRGLFGVAGKM------RVPSQLLNTELTERLFSMAHTVALDLAAINIQRG 1162
            ..|::: ....|.|||||.....|.      |......|.:..|...|       ||.:|:|||.
  Fly   432 TIRLLDTSDNFDALLRGLATQLHKRSDGNIDREIKHYFNRKEFEEYGS-------DLKSIDIQRA 489

Human  1163 RDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSR 1227
            ||.|:..|:|.|.:|.|..|..:.|..:||...:| ..|:|||.:..:::|.....:|..||.:.
  Fly   490 RDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKI-SLLRRLYATPDDVELGVGGTLEYHVPDAL 553

Human  1228 LGPTLMCLLSTQFKRLRDGDRLWY--ENPGVFSPAQLTQIKQTSLARILCDNADNITRVQSDVFR 1290
            .||||:|::..||...|.|||.::  ||.|.||.|||.:|::.||:.:.|.||:.:..:|.:|| 
  Fly   554 FGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNANYLHLIQPNVF- 617

Human  1291 VAEFPHGYG---SCDEIPRVDLRVWQD 1314
              .||:.:.   :|:.||::||..|||
  Fly   618 --VFPNSHNLLLNCNFIPQIDLSKWQD 642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PXDNNP_036425.1 leucine-rich repeat 45..63 CDD:275380
leucine-rich repeat 66..87 CDD:275380
LRR 1 87..108
LRR_4 110..151 CDD:289563
LRR_8 111..170 CDD:290566
LRR 2 111..132
leucine-rich repeat 112..135 CDD:275378
LRR_4 135..175 CDD:289563
LRR 3 135..156
leucine-rich repeat 136..159 CDD:275378
LRR_8 158..>195 CDD:290566
LRR 4 159..180
leucine-rich repeat 160..183 CDD:275378
leucine-rich repeat 184..196 CDD:275378
TPKR_C2 192..243 CDD:301599
Ig 246..333 CDD:299845
I-set 246..333 CDD:254352
I-set 342..429 CDD:254352
Ig 346..429 CDD:299845
I-set 433..519 CDD:254352
Ig3_Peroxidasin 446..519 CDD:143222
I-set 525..611 CDD:254352
Ig4_Peroxidasin 542..610 CDD:143223
An_peroxidase 741..1282 CDD:281139 177/576 (31%)
peroxidasin_like 864..1303 CDD:188658 141/472 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1342..1380
VWC 1415..1470 CDD:214564
CG4009NP_001262655.1 An_peroxidase_like 77..>367 CDD:265428 101/348 (29%)
An_peroxidase 95..610 CDD:281139 177/576 (31%)
peroxinectin_like 228..605 CDD:188655 125/401 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150052
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D276568at2759
OrthoFinder 1 1.000 - - FOG0000202
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.750

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