DRSC/TRiP Functional Genomics Resources

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Protein Alignment PXDN and Irc

DIOPT Version :10

Sequence 1:NP_036425.1 Gene:PXDN / 7837 HGNCID:14966 Length:1479 Species:Homo sapiens
Sequence 2:NP_650584.1 Gene:Irc / 42049 FlyBaseID:FBgn0038465 Length:697 Species:Drosophila melanogaster


Alignment Length:819 Identity:201/819 - (24%)
Similarity:329/819 - (40%) Gaps:231/819 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   591 RYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPN 655
            :|.|:....||::.::.:.:.:..||:...:...|:..::.:.|...::|..:        |..:
  Fly     5 QYICLLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVNRQK--------RLED 61

Human   656 DLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL 720
            :||.      ...||:                           ||:..|      .|.|:.:.:|
  Fly    62 NLLG------SDITVK---------------------------NGSLSH------AQLLDTLPSL 87

Human   721 SGCTAHRRVNNCSDMCFHQKYRTHDGTC--NNL----------QHPM-WGASLT----------- 761
                |.::.|..:...........:..|  ||:          |.|: .|:||.           
  Fly    88 ----ASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECENSLKGNR 148

Human   762 ----AFERLL-KSVYENGFNTPRGINPHRLY--NGHALPMPRLVSTTLIGTETVTPD-----EQF 814
                ||.||| .|.|.|||        ::::  :|....:|...|   |..|...||     :|.
  Fly   149 EGHYAFRRLLGSSHYRNGF--------YQMFPNSGRRETVPAAWS---ISKELYEPDHIQISKQQ 202

Human   815 TH------MLMQWGQFLDHDLDSTVVALSQARFSDGQ--HCSNVCSND----------PPCFSVM 861
            |.      .|.||.||::|||...|   ||: .|:|.  .|   ||.|          |.|..::
  Fly   203 TFESNSNLALPQWAQFVEHDLSKPV---SQS-MSNGAPIEC---CSRDQINLQPRHHHPACAPIL 260

Human   862 IPPNDSRARSGAR-----CMFFVRSSPV---CGSGMTSLLMNSVYPREQINQLTSYIDASNVYGS 918
            ..|       |.:     |:.:|||:..   |..|          ..||:||.|..:|.|.:||.
  Fly   261 YQP-------GGKYDVPSCLNYVRSALAVADCNFG----------GAEQLNQATGSLDLSQLYGF 308

Human   919 TEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGP--PTECMRDENESPI---PCFLAGDHRA 978
            |....|.:|.|..  ||||..........|||.||..  |:.|.|    :.|   .||.|||.|.
  Fly   309 TAAAERKLRVLEG--GLLRSTPRGEFDNALLPIATDTEGPSFCAR----ATIGDGTCFAAGDSRV 367

Human   979 NEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEI-QHITYQHWLPKILGEV 1042
            |.......::|::.|.||::|.||.:.||.|..:.: ::..|.|..:| :.:..:.|||::||: 
  Fly   368 NSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKL-FQAAKAVNVDIYRRVVIEEWLPEVLGQ- 430

Human  1043 GMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLV-NPLL--------YRLDENFQPI-AQDHLP 1097
              :...|.....|.....:.|.||.||.||..::: |.||        |..::|.|.: ....||
  Fly   431 --KMSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELP 493

Human  1098 ------LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLA- 1155
                  |.:..:.|                     |::..||.|| .:.|.|.:. .|:.:|.| 
  Fly   494 TKNLFELKEEIYKP---------------------KLQYTSQKLN-NILESLLNQ-ETMKMDAAY 535

Human  1156 ------------------AINIQRGRDHGIPPYHDYRVYCNLS-AAHTFEDLKNEIKNPEIREKL 1201
                              |.:||||||||:.||:.|...|.|| ...:::|.::.|.: ::.:||
  Fly   536 SGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPS-DVLDKL 599

Human  1202 KRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLT-QI 1265
            |.:|.|..::||....:.|:.|.|| :|||..|::|.||..:...:    :...|....:|. |.
  Fly   600 KTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISEQFVHVLKQN----QQKAVQKHTELVEQY 659

Human  1266 KQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEI 1304
            :..:..::||.|: .::.|..::|::....:...||:::
  Fly   660 RHFNGTKLLCLNS-GLSAVPQNIFQLPSARNQMVSCEDV 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PXDNNP_036425.1 leucine-rich repeat 45..63 CDD:275380
LRR 1. /evidence=ECO:0000255 61..84
leucine-rich repeat 66..87 CDD:275380
LRR 2. /evidence=ECO:0000255 85..108
LRR <97..>215 CDD:443914
LRR 3. /evidence=ECO:0000255 110..132
leucine-rich repeat 112..135 CDD:275378
LRR 4. /evidence=ECO:0000255 133..156
leucine-rich repeat 136..159 CDD:275378
LRR 5. /evidence=ECO:0000255 157..180
leucine-rich repeat 160..183 CDD:275378
LRR 6. /evidence=ECO:0000255 182..204
leucine-rich repeat 184..196 CDD:275378
LRRCT 192..243 CDD:214507
I-set 246..333 CDD:400151
Ig strand B 263..267 CDD:409490
Ig strand C 276..280 CDD:409490
Ig strand F 314..319 CDD:409490
Ig strand G 328..331 CDD:409490
I-set 342..429 CDD:400151
Ig strand B 359..363 CDD:409544
Ig strand C 372..376 CDD:409544
Ig strand E 395..399 CDD:409544
Ig strand F 409..414 CDD:409544
Ig strand G 422..425 CDD:409544
Ig3_Peroxidasin 446..519 CDD:143222
Ig strand B 450..454 CDD:143222
Ig strand C 463..467 CDD:143222
Ig strand E 485..489 CDD:143222
Ig strand F 499..504 CDD:143222
Ig strand G 513..516 CDD:143222
Ig4_Peroxidasin 542..610 CDD:143223 4/18 (22%)
Ig strand B 542..546 CDD:143223
Ig strand C 555..559 CDD:143223
Ig strand E 577..581 CDD:143223
Ig strand F 591..596 CDD:143223 2/4 (50%)
Ig strand G 605..608 CDD:143223 0/2 (0%)
peroxidasin_like 864..1303 CDD:188658 133/489 (27%)
LRR 7. /evidence=ECO:0000255 1151..1175 14/42 (33%)
LRR 8. /evidence=ECO:0000255 1270..1291 5/20 (25%)
Required in homotrimerization. /evidence=ECO:0000269|PubMed:31295557 1315..1411
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1342..1380
VWC 1415..1470 CDD:214564
IrcNP_650584.1 An_peroxidase 151..682 CDD:460804 168/605 (28%)
Blue background indicates that the domain is not in the aligned region.

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