DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PXDN and Irc

DIOPT Version :9

Sequence 1:NP_036425.1 Gene:PXDN / 7837 HGNCID:14966 Length:1479 Species:Homo sapiens
Sequence 2:NP_001262653.1 Gene:Irc / 42049 FlyBaseID:FBgn0038465 Length:697 Species:Drosophila melanogaster


Alignment Length:819 Identity:201/819 - (24%)
Similarity:329/819 - (40%) Gaps:231/819 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   591 RYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPN 655
            :|.|:....||::.::.:.:.:..||:...:...|:..::.:.|...::|..:        |..:
  Fly     5 QYICLLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVNRQK--------RLED 61

Human   656 DLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL 720
            :||.      ...||:                           ||:..|      .|.|:.:.:|
  Fly    62 NLLG------SDITVK---------------------------NGSLSH------AQLLDTLPSL 87

Human   721 SGCTAHRRVNNCSDMCFHQKYRTHDGTC--NNL----------QHPM-WGASLT----------- 761
                |.::.|..:...........:..|  ||:          |.|: .|:||.           
  Fly    88 ----ASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECENSLKGNR 148

Human   762 ----AFERLL-KSVYENGFNTPRGINPHRLY--NGHALPMPRLVSTTLIGTETVTPD-----EQF 814
                ||.||| .|.|.|||        ::::  :|....:|...|   |..|...||     :|.
  Fly   149 EGHYAFRRLLGSSHYRNGF--------YQMFPNSGRRETVPAAWS---ISKELYEPDHIQISKQQ 202

Human   815 TH------MLMQWGQFLDHDLDSTVVALSQARFSDGQ--HCSNVCSND----------PPCFSVM 861
            |.      .|.||.||::|||...|   ||: .|:|.  .|   ||.|          |.|..::
  Fly   203 TFESNSNLALPQWAQFVEHDLSKPV---SQS-MSNGAPIEC---CSRDQINLQPRHHHPACAPIL 260

Human   862 IPPNDSRARSGAR-----CMFFVRSSPV---CGSGMTSLLMNSVYPREQINQLTSYIDASNVYGS 918
            ..|       |.:     |:.:|||:..   |..|          ..||:||.|..:|.|.:||.
  Fly   261 YQP-------GGKYDVPSCLNYVRSALAVADCNFG----------GAEQLNQATGSLDLSQLYGF 308

Human   919 TEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGP--PTECMRDENESPI---PCFLAGDHRA 978
            |....|.:|.|..  ||||..........|||.||..  |:.|.|    :.|   .||.|||.|.
  Fly   309 TAAAERKLRVLEG--GLLRSTPRGEFDNALLPIATDTEGPSFCAR----ATIGDGTCFAAGDSRV 367

Human   979 NEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEI-QHITYQHWLPKILGEV 1042
            |.......::|::.|.||::|.||.:.||.|..:.: ::..|.|..:| :.:..:.|||::||: 
  Fly   368 NSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKL-FQAAKAVNVDIYRRVVIEEWLPEVLGQ- 430

Human  1043 GMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLV-NPLL--------YRLDENFQPI-AQDHLP 1097
              :...|.....|.....:.|.||.||.||..::: |.||        |..::|.|.: ....||
  Fly   431 --KMSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELP 493

Human  1098 ------LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLA- 1155
                  |.:..:.|                     |::..||.|| .:.|.|.:. .|:.:|.| 
  Fly   494 TKNLFELKEEIYKP---------------------KLQYTSQKLN-NILESLLNQ-ETMKMDAAY 535

Human  1156 ------------------AINIQRGRDHGIPPYHDYRVYCNLS-AAHTFEDLKNEIKNPEIREKL 1201
                              |.:||||||||:.||:.|...|.|| ...:::|.::.|.: ::.:||
  Fly   536 SGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPS-DVLDKL 599

Human  1202 KRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLT-QI 1265
            |.:|.|..::||....:.|:.|.|| :|||..|::|.||..:...:    :...|....:|. |.
  Fly   600 KTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISEQFVHVLKQN----QQKAVQKHTELVEQY 659

Human  1266 KQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEI 1304
            :..:..::||.|: .::.|..::|::....:...||:::
  Fly   660 RHFNGTKLLCLNS-GLSAVPQNIFQLPSARNQMVSCEDV 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PXDNNP_036425.1 leucine-rich repeat 45..63 CDD:275380
leucine-rich repeat 66..87 CDD:275380
LRR 1 87..108
LRR_4 110..151 CDD:289563
LRR_8 111..170 CDD:290566
LRR 2 111..132
leucine-rich repeat 112..135 CDD:275378
LRR_4 135..175 CDD:289563
LRR 3 135..156
leucine-rich repeat 136..159 CDD:275378
LRR_8 158..>195 CDD:290566
LRR 4 159..180
leucine-rich repeat 160..183 CDD:275378
leucine-rich repeat 184..196 CDD:275378
TPKR_C2 192..243 CDD:301599
Ig 246..333 CDD:299845
I-set 246..333 CDD:254352
I-set 342..429 CDD:254352
Ig 346..429 CDD:299845
I-set 433..519 CDD:254352
Ig3_Peroxidasin 446..519 CDD:143222
I-set 525..611 CDD:254352 4/19 (21%)
Ig4_Peroxidasin 542..610 CDD:143223 4/18 (22%)
An_peroxidase 741..1282 CDD:281139 175/645 (27%)
peroxidasin_like 864..1303 CDD:188658 133/489 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1342..1380
VWC 1415..1470 CDD:214564
IrcNP_001262653.1 An_peroxidase 151..672 CDD:281139 166/594 (28%)
An_peroxidase_like 290..637 CDD:265428 113/381 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D276568at2759
OrthoFinder 1 1.000 - - FOG0000202
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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