DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PXDN and Pxn

DIOPT Version :9

Sequence 1:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens
Sequence 2:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster

Alignment Length:	1551	Identity:	643/1551 - (41%)
Similarity:	887/1551 - (57%)	Gaps:	130/1551 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREI 77
            ||.|:|..|.|..:|.       ||:.|.|...||||:...|.|||.:...|..||||||.|.|:
  Fly    10 LLGLLLLLAGGVQSVY-------CPAGCTCLERTVRCIRAKLSAVPKLPQDTQTLDLRFNHIEEL 67

Human    78 QPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLH 142
            ...||..|..|.||.||:|::..:..||...|..|:::||..|.:..:....|:.:..||.::|.
  Fly    68 PANAFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFLE 132

Human   143 FNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEIL-----W 202
            .|.|..|....|.:||:|.||.::||::|.|....||.|.::||||||.|.:.|:|.:.     |
  Fly   133 NNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAIDCNCGVYSLWRRW 197

Human   203 LADLLKTYAESGNAQAAAI---CEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVY 264
            ..|:.:        |..:|   |..|:.:|.:..:::......|.:|:....||||.|.:|..|.
  Fly   198 HLDVQR--------QLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVE 254

Human   265 FTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ 329
            .:|...|.|:|:|.|:.|..||.::..::..:|..|:|:|::...:|.|||||:|:|..|.:::|
  Fly   255 LSCEVTGLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQ 319

Human   330 EVTLRYFGS---------------------------------PARPTFVIQPQNTEVLVGES--V 359
            .|.|...|.                                 |:.|.|..||.:..|.:..|  |
  Fly   320 PVRLVVNGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHV 384

Human   360 TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424
            .|:|:|:|.|.|.|.|....|..|...|.:.:..:|.|.:....|..:|.|.|.|.|::.||.||
  Fly   385 LLDCAASGWPQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQAT 449

Human   425 AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVL-SSGTLR 488
            |.|.::.||:....||.:.:..|:....:|:|.|||.|.|.|...|..|..:...|.| :..|..
  Fly   450 ARIELKELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTEL 514

Human   489 ISGVALHDQ-GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASI-PSDTTVEVGANVQLPCSSQGE 551
            :.|.|..:. |.|.|.|.|..|...|.|.:.|:...:|...:| ||:.....|..::|||.:. :
  Fly   515 VVGAARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQAD-Q 578

Human   552 PEPA--ITWNKDG------VQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMV 608
            ||..  |:|..||      ||:.|  |:.||..|.|.:.:|...|.|||||..:|..|.||.|.:
  Fly   579 PEDGLQISWRHDGRLIDPNVQLAE--KYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASAL 641

Human   609 LSV-NVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSR----PRSPNDLLALFRYPRDPY 668
            ::: |..|:: .||.:|..:..||...:|.|||:|...||.:|    |.:..:||.:||:|...
  Fly   642 VTIRNNVDLA-PGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTGE- 704

Human   669 TVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCS 733
            ..:.|||.||:||||..|::|||.|..:.:....|.:.||:|.::|:|:|.||||..||.:.||:
  Fly   705 ARQLARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNCT 769

Human   734 DMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLV 798
            |||||.:||:.||||||||||.||||||||.||...:|||||:.|.|.....||:|||.|..|||
  Fly   770 DMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLV 834

Human   799 STTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIP 863
            ||:|:.|:.:|||.:.|||:||||||||||||..:.::|...: ||..|...|...|||:.:.:|
  Fly   835 STSLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESW-DGIDCKKSCEMAPPCYPIEVP 898

Human   864 PNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIRD 928
            |||.|.|: .||:..||||.:||||||||..:||..||||||||||||||.|||.:...|:.:|:
  Fly   899 PNDPRVRN-RRCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELRN 962

Human   929 LASHRGLLRQGIVQRSGKPLLPFATGPP-TECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWF 992
            |.|..||||.|:.....|.:||||.... .:|.|:.:|:.:.||::||.|.|||:||.:|||:|.
  Fly   963 LTSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTIWM 1027

Human   993 REHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGI 1057
            |||||||::|.::|.||||||:|.|.||||||::||||::.|||.|:||.||..:|||.||:|.:
  Fly  1028 REHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGEYQGYNPQL 1092

Human  1058 NAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLF 1122
            |..|.|.|||||.|||||::||:|:||:|.||||.|.||.||||||:|:|:..|||:|||:||..
  Fly  1093 NPSIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGFL 1157

Human  1123 GVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFED 1187
            .|..|::.|.|.|||||||:||..||.|||||||||||||||||:|.|:.||..|||:.|..|||
  Fly  1158 AVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFED 1222

Human  1188 LKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYE 1252
            |..||.:.|||:|:|.|||...|:|::...::||.|.|.::||...|||..||:||||||||:||
  Fly  1223 LAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYE 1287

Human  1253 NPGVFSPAQLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCE 1317
            |||||||.|||||||.:..|:|||..||..:|..:||.:|:...||..|::|..::|.:||:|
  Fly  1288 NPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQEC-- 1350

Human  1318 DCRTRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDASGT 1382
                 |:.|:....|.       ||.....||::..:| ..:|::.:.::.:.|..|........
  Fly  1351 -----GRCNSPPAIFD-------SYIPQTYTKRSNRQK-RDLGKENDEVATAESYDSPLESLYDV 1402

Human  1383 NDFR-----EFVLEMQKTITDLRTQIKKLE-------------------------SRLSTTECVD 1417
            |:.|     |.:...||.:..|..:::|||                         |:...:.|||
  Fly  1403 NEERVSGLEELIGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPKRSHCVD 1467

Human  1418 AGGESHANNTKWKKDACTICECKDGQVTCFVEACPPATC---AVPVNIPGACCPVC 1470
            ..|.:..||..|..|.||.|.|..|||.|..|.|...:|   ..|:..|.||||.|
  Fly  1468 DKGTTRLNNEVWSPDVCTKCNCFHGQVNCLRERCGEVSCPPGVDPLTPPEACCPHC 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380	8/17 (47%)
		leucine-rich repeat	66..87	CDD:275380	11/20 (55%)
		LRR 1	87..108		8/20 (40%)
		LRR_4	110..151	CDD:289563	11/40 (28%)
		LRR_8	111..170	CDD:290566	19/58 (33%)
		LRR 2	111..132		5/20 (25%)
		leucine-rich repeat	112..135	CDD:275378	5/22 (23%)
		LRR_4	135..175	CDD:289563	16/39 (41%)
		LRR 3	135..156		7/20 (35%)
		leucine-rich repeat	136..159	CDD:275378	8/22 (36%)
		LRR_8	158..>195	CDD:290566	18/36 (50%)
		LRR 4	159..180		8/20 (40%)
		leucine-rich repeat	160..183	CDD:275378	10/22 (45%)
		leucine-rich repeat	184..196	CDD:275378	7/11 (64%)
		TPKR_C2	192..243	CDD:301599	10/58 (17%)
		Ig	246..333	CDD:299845	32/86 (37%)
		I-set	246..333	CDD:254352	32/86 (37%)
		I-set	342..429	CDD:254352	32/88 (36%)
		Ig	346..429	CDD:299845	30/84 (36%)
		I-set	433..519	CDD:254352	27/87 (31%)
		Ig3_Peroxidasin	446..519	CDD:143222	24/74 (32%)
		I-set	525..611	CDD:254352	34/94 (36%)
		Ig4_Peroxidasin	542..610	CDD:143223	29/75 (39%)
		An_peroxidase	741..1282	CDD:281139	318/541 (59%)
		peroxidasin_like	864..1303	CDD:188658	256/439 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380		7/37 (19%)
		VWC	1415..1470	CDD:214564	25/57 (44%)
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	40/109 (37%)
		leucine-rich repeat	54..77	CDD:275380	12/22 (55%)
		LRR_8	55..112	CDD:290566	24/56 (43%)
		leucine-rich repeat	78..101	CDD:275380	9/22 (41%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		LRR_8	124..184	CDD:290566	26/59 (44%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_4	148..185	CDD:289563	18/36 (50%)
		leucine-rich repeat	150..173	CDD:275380	10/22 (45%)
		Ig	240..325	CDD:299845	32/84 (38%)
		IG_like	242..325	CDD:214653	32/82 (39%)
		I-set	366..450	CDD:254352	28/83 (34%)
		Ig	384..451	CDD:143165	24/66 (36%)
		I-set	458..546	CDD:254352	27/87 (31%)
		Ig	472..536	CDD:299845	21/63 (33%)
		I-set	553..644	CDD:254352	33/93 (35%)
		Ig	570..643	CDD:299845	29/75 (39%)
		An_peroxidase	777..1317	CDD:281139	318/541 (59%)
		peroxidasin_like	898..1338	CDD:188658	257/440 (58%)
		VWC	1465..1523	CDD:278520	25/57 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150045
Domainoid	1	1.000	667	1.000	Domainoid score	I148
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33907
Inparanoid	1	1.050	1154	1.000	Inparanoid score	I209
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46064
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	1	1.000	-	-		otm40686
orthoMCL	1	0.900	-	-		OOG6_105829
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2739
SonicParanoid	1	1.000	-	-		X2950
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800