DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PXDN and Lar

DIOPT Version :9

Sequence 1:NP_036425.1 Gene:PXDN / 7837 HGNCID:14966 Length:1479 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:959 Identity:212/959 - (22%)
Similarity:341/959 - (35%) Gaps:295/959 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDD-GTLMIQNTQE 309
            |.|..:||:..|..|....|.|.|.|:|.|.|:|.:|..::| .|.||..:|:. |.:.|...:.
  Fly    36 PEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVS-GTQSRYTVLEQPGGISILRIEP 99

Human   310 T----DQGIYQCMAKNVAGEVKTQEVTLR-YFG--SPARPTFVIQPQNTEVL-VGESVTLECSAT 366
            .    |...|:|:|:|..|:..:.:.||. |.|  :||....:.|...|.|: ||.:|.:.|.|.
  Fly   100 VRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAI 164

Human   367 GHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA---FII 428
            |:|.|.|.|.:........:||.:: ..|.|.|:|..:.|.|:|.|.|.|::.:.|:.|   ::.
  Fly   165 GNPTPNIYWIKNQTKVDMSNPRYSL-KDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVK 228

Human   429 VQALPQFTVTPQDRV--VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISG 491
            |:.:|.....|.:.:  |:.|..::..|.|.|:|.|.:.|.||...|:.: ..:.:....|::  
  Fly   229 VRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPE-NEMPIGRNVLQL-- 290

Human   492 VALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGA-NVQLPCSSQGEPEP 554
            :.:.:...|.|.|.:.:|....|:.:.||...|     .|:|..: ||.| :|:|..|.:| ||.
  Fly   291 INIQESANYTCIAASTLGQIDSVSVVKVQSLPT-----APTDVQISEVTATSVRLEWSYKG-PED 349

Human   555 ----AITWN-KDGVQVTE--SG-----------------KFHISPEGFLTINDVG------PA-- 587
                .|.:. |:..|...  ||                 :|::     :.:|::|      ||  
  Fly   350 LQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYV-----IAVNNIGRGPPSAPATC 409

Human   588 -------DAGRYECVARN----TIGSAS-------------------VSMVLSVNVPDVSRNGDP 622
                   ...:.|...||    |:.|::                   |....:.|.|:.|.|...
  Fly   410 TTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQM 474

Human   623 FVATSIVEAIATVDRAINSTRTHLFDSR---PRS-PNDLLALFRYPRDPYTVEQARAGEIFER-- 681
            ...:.:.........||.:.|...:.|.   |.| |..:.|....|..|   ...||.:|.|.  
  Fly   475 VDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQP---SNFRATDIGETAV 536

Human   682 TLQLIQ-----EHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKY 741
            |||..:     |::.|        ...::||..:.|           ..|:|::|      .:.|
  Fly   537 TLQWTKPTHSSENIVH--------YELYWNDTYANQ-----------AHHKRISN------SEAY 576

Human   742 RTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTE 806
             |.||...:..:.:|.|:        :|....|..||              |:|  |.|...|  
  Fly   577 -TLDGLYPDTLYYIWLAA--------RSQRGEGATTP--------------PIP--VRTKQYG-- 614

Human   807 TVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIPPNDSRARS 871
              .|....|.:.          ..||.::||..               ||      |...|..|.
  Fly   615 --APPRNITAIA----------TSSTTISLSWL---------------PP------PVERSNGRI 646

Human   872 GARCMFFVR------SSPVCGSGMTSLLMNSVYPREQINQLTSY---IDASNVYGSTEHEARSIR 927
            ....:|||.      .:......|||:::      :::.:.|.|   :.|....|....      
  Fly   647 IYYKVFFVEVGREDDEATTMTLNMTSIVL------DELKRWTEYKIWVLAGTSVGDGPR------ 699

Human   928 DLASHRGLLR---------QGIVQRSGKPL----LPFATGPPTEC---------------MRDEN 964
               ||..:||         |.:   ...||    :..:..||.|.               :|||.
  Fly   700 ---SHPIILRTQEDVPGDPQDV---KATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEG 758

Human   965 ESPIPCFLAGDHRANEQLGLTSMHTLWF-----REHNRIATELLKLNPHWDGD------------ 1012
            :.    ||      ||......:.||.|     :...:.:.::..|....|||            
  Fly   759 KG----FL------NEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGG 813

Human  1013 -----TI---YYETRKIVGAEIQHITYQHWLPKILGEVGMRTLGEYHGY 1053
                 |:   ..|...||..|::      |      |...:|.||..||
  Fly   814 VPVRPTVSLKIMEREPIVSIELE------W------ERPAQTYGELRGY 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PXDNNP_036425.1 leucine-rich repeat 45..63 CDD:275380
leucine-rich repeat 66..87 CDD:275380
LRR 1 87..108
LRR_4 110..151 CDD:289563
LRR_8 111..170 CDD:290566
LRR 2 111..132
leucine-rich repeat 112..135 CDD:275378
LRR_4 135..175 CDD:289563
LRR 3 135..156
leucine-rich repeat 136..159 CDD:275378
LRR_8 158..>195 CDD:290566
LRR 4 159..180
leucine-rich repeat 160..183 CDD:275378
leucine-rich repeat 184..196 CDD:275378
TPKR_C2 192..243 CDD:301599
Ig 246..333 CDD:299845 28/91 (31%)
I-set 246..333 CDD:254352 28/91 (31%)
I-set 342..429 CDD:254352 27/90 (30%)
Ig 346..429 CDD:299845 27/86 (31%)
I-set 433..519 CDD:254352 19/87 (22%)
Ig3_Peroxidasin 446..519 CDD:143222 16/72 (22%)
I-set 525..611 CDD:254352 27/149 (18%)
Ig4_Peroxidasin 542..610 CDD:143223 22/129 (17%)
An_peroxidase 741..1282 CDD:281139 72/375 (19%)
peroxidasin_like 864..1303 CDD:188658 48/252 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1342..1380
VWC 1415..1470 CDD:214564
LarNP_001260594.1 Ig 35..129 CDD:299845 30/93 (32%)
I-set 36..129 CDD:254352 30/93 (32%)
IG_like 146..227 CDD:214653 26/81 (32%)
Ig 159..228 CDD:299845 21/69 (30%)
I-set 234..318 CDD:254352 18/86 (21%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 16/70 (23%)
fn3 324..404 CDD:278470 19/85 (22%)
FN3 423..514 CDD:238020 16/90 (18%)
FN3 520..610 CDD:238020 30/142 (21%)
FN3 616..707 CDD:238020 24/136 (18%)
FN3 712..810 CDD:238020 20/110 (18%)
FN3 832..907 CDD:238020 8/31 (26%)
FN3 914..1005 CDD:238020
FN3 1012..1101 CDD:238020
fn3 1106..1198 CDD:278470
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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