DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PXDN and Pxd

DIOPT Version :9

Sequence 1:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens
Sequence 2:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster

Alignment Length:	610	Identity:	211/610 - (34%)
Similarity:	314/610 - (51%)	Gaps:	63/610 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   735 MCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVS 799
            :|....|||.||:||:|:.|..|.:.:.:.|||...|.:|.:.|.     |...|..||..||||
  Fly    99 VCEKTAYRTLDGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPT-----RSVTGDELPSARLVS 158

Human   800 TTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSND---------- 854
            ....|.:.| ||.:||...|||||.:.||: |.....:|::    :|.:..|::|
  Fly   159 LVAFGEQDV-PDPEFTLHNMQWGQIMTHDM-SMQAGGTQSK----KHPTRCCTDDGRLIGLDTAH 217

Human   855 PPCFSVMIPPND-SRARSGARCMFFVRSSPVCGSGMTSLLMNSVY---PREQINQLTSYIDASNV 915
            ..||::::||:| :.::.|..|:.|||:       :|....|..|   |.||:..:|||:|.|.|
  Fly   218 KTCFAIIVPPHDPAYSQVGTECLNFVRT-------LTDRDSNCQYQGGPAEQLTVVTSYLDLSLV 275

Human   916 YGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANE 980
            ||::..:...||:....|.:    :.:|:|...||.:.....:|  |..::...|:.:||.|.|:
  Fly   276 YGNSIQQNSDIREFQGGRMI----VEERNGAKWLPLSRNVTGDC--DAVDASEVCYRSGDVRVNQ 334

Human   981 QLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGM- 1044
            ..||..:.|:..|||||||..|..||||:|..|::.|.|||..|:.|.|:|..|||..||...|
  Fly   335 NPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENML 399

Human  1045 --RTL-----GEY-HGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKA 1101
              |.:     |.| :.:||.|:..:.|..||||||:.|:.:...|..|.|..|.:..  |.|...
  Fly   400 KNRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVLGS--LTLSDW 462

Human  1102 FFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQL----LNTELTERLFSMAHTVALDLAAINIQRG 1162
            |..|..|......|.|.|      |....|.:|    .:.::...||........||.:::|||.
  Fly   463 FNRPGIIEVGDNFDSLTR------GHATQPEELTDINFDRQIKHFLFRRNMPFGSDLRSLDIQRN 521

Human  1163 RDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSR 1227
            ||||:..|:|.|.:|.|..||::|.. .::.:|.|.||||.||.|..::||.....:|..|.|:.
  Fly   522 RDHGLASYNDMREFCGLRRAHSWEGY-GDLISPPILEKLKSLYPSHEDVDLTVGASLEAHVAGAL 585

Human  1228 LGPTLMCLLSTQFKRLRDGDRLWYENPGV---FSPAQLTQIKQTSLARILCDNADNITRVQSDVF 1289
            .|||.:|:|:.||.|.|.|||.::||...   |:|.||.::::.|:||:||||.::|:.:|.:.|
  Fly   586 AGPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLLCDNGNHISSMQPEAF 650

Human  1290 RVAEFPHGYGSCDEIPRVDLRVWQD 1314
            |.....:....|..||:|||..|.|
  Fly   651 RTVSHSNPIIPCSNIPQVDLTKWID 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		LRR 1	87..108
		LRR_4	110..151	CDD:289563
		LRR_8	111..170	CDD:290566
		LRR 2	111..132
		leucine-rich repeat	112..135	CDD:275378
		LRR_4	135..175	CDD:289563
		LRR 3	135..156
		leucine-rich repeat	136..159	CDD:275378
		LRR_8	158..>195	CDD:290566
		LRR 4	159..180
		leucine-rich repeat	160..183	CDD:275378
		leucine-rich repeat	184..196	CDD:275378
		TPKR_C2	192..243	CDD:301599
		Ig	246..333	CDD:299845
		I-set	246..333	CDD:254352
		I-set	342..429	CDD:254352
		Ig	346..429	CDD:299845
		I-set	433..519	CDD:254352
		Ig3_Peroxidasin	446..519	CDD:143222
		I-set	525..611	CDD:254352
		Ig4_Peroxidasin	542..610	CDD:143223
		An_peroxidase	741..1282	CDD:281139	198/570 (35%)
		peroxidasin_like	864..1303	CDD:188658	158/458 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380
		VWC	1415..1470	CDD:214564
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	198/570 (35%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	140/392 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.700