DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CACNA2D1 and CG16868

DIOPT Version :9

Sequence 1:	XP_006716181.1	Gene:	CACNA2D1 / 781	HGNCID:	1399	Length:	1110	Species:	Homo sapiens
Sequence 2:	NP_611469.1	Gene:	CG16868 / 37298	FlyBaseID:	FBgn0034498	Length:	1449	Species:	Drosophila melanogaster

Alignment Length:	1267	Identity:	251/1267 - (19%)
Similarity:	429/1267 - (33%)	Gaps:	422/1267 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    37 VDKMQEDLVTL----AKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKAL 97
            |.|:||...::    ||.||...|     ....|...|.|...|.|...:.|     ||.:.:..
  Fly    85 VAKIQEIFDSMHFSSAKGASNTRQ-----ASSNDSNVVNPQLQRDLQLFSER-----LSKKIQKA 139

Human    98 VRLALEAEKV---------QAAHQWREDFASNEVVYYNAKDDLDPE------KNDSEPGSQRI-- 145
            ..:.||..::         |.::...:|.:.:|:       ||:.|      :|.:.|..:.:
  Fly   140 TYVVLELRELLRYNLTKVWQYSYDDEDDESESEM-------DLEMELEDLHARNTASPTDEHVQL 197

Human   146 ---------KPVFIEDANFG----RQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNR 197
                     :|.:..|..:|    :.|.|....:.|           ||.|....|......:|.
  Fly   198 YLNTQIESCQPDYETDLEYGSSSTQSIHYNRQQIQI-----------LNYLKSDDARATFLNENN 251

Human   198 EEDPSLLWQVFGSATGLARYYPASPWVDNSRTP---NKI-DLY----------DVRRRPWYIQGA 248
            ....::...:......|.|....|...:::..|   |.. .:|          .:..|..|: .|
  Fly   252 ARSLAVNGYISNQLVLLKRRLSRSDAENSNSKPISGNHFKHIYFLSNSDGASASLHFRQLYV-SA 315

Human   249 ASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDD---FVNVASFNSNAQDVSCFQ----H 306
            ...|.:|.|:||..::|.....|.::.|.|||:.|.|.|   .|.||| .:|...:..|.    |
  Fly   316 IKQKFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVAS-EANFMSLEAFPAEAGH 379

Human   307 LVQANVR-NKKVLKDAVNNIT-AKGITDYKKGFSFAFEQL------------------------L 345
            .:.:..| :|:.:...:|::: |:..|::..||.::||.|                        |
  Fly   380 GIYSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLHRLQQSGMINTAEQPVEFVYITRGL 444

Human   346 NYNVSRANCNKIIMLFTDGGEE-RAQEIFNK---YNKDKKV---RVFTFSVGQHNYDRGPIQWMA 403
            ..|:|.|..  ::.:..||... ||..|.|.   ...:|::   :.|...|...||.:
  Fly   445 LTNLSDAMA--VLRVVADGQRRLRAPVIINTCAVVLDEKRIMYEKQFLNDVASQNYTK------- 500

Human   404 CENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAK------------------------QV 444
                   ||| .:.:...:.||..:::||..||:...|:                        :|
  Fly   501 -------YEI-DVASWWPSGQEASELVGRFYVLSKMHAETSLPQTSSRIFGPLFQERYLSDTLEV 557

Human   445 QWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPN 509
            ....|..|:.::.:.||..:|.:                  ||:||::.|.|:......:....:
  Fly   558 HPPVVDADSGDVLVSITHAVPPY------------------GVVGVNLYLSDLLEDLLNYPSTTS 604

Human   510 ------GYYFAID-PNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELE 567
                  ||.|.:| ..|..|.||         ..|       ||.||...|. ||.:.:|  |..
  Fly   605 SAKQGLGYAFLLDRSTGNTLAHP---------AFP-------RPLIQRETSY-PVNIAYL--ENA 650

Human   568 NDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIK 632
            .|....||::::..|||..|....|..|      :..|||.|..|.|. |.|.||
  Fly   651 TDFSSHIRDRLLREESGNVTTDVYVGRQ------RLQRTYYWQSVLGF-YVLCLV---------- 698

Human   633 AKLEETITQARS-KKGKMKDS-ETLKPDNFEES------------GYTFIAPRDYC---NDLKIS 680
            :...:|:....| ::..:||: ...:|..:.||            |.:  ||...|   ..:...
  Fly   699 SSGGDTLRNVSSTQRYNLKDTVSNYEPGYYGESMDLLYHRLDLNQGGS--APPKTCRYFRQVATM 761

Human   681 DNNTEFL--LNFNE---FIDRKTPNNPSCNADLINRVLLDA-----------------GFTNELV 723
            |..|.||  ..|..   |:....|.....:.:.|...|.|:                 |...:.:
  Fly   762 DAPTLFLSAAAFESPFGFLHNNRPRTQLRHVESIMAYLRDSSGLLANMGLRPSIRHEVGVLYQAM 826

Human   724 QNYWSKQKNIKG-----VKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSL-DNDNYVF 782
            |....:.::.:|     |..|::.:..|:.::||   |.....:.:.....:::::: .....|.
  Fly   827 QQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYP---GCLLSSSYDPTRRPWFRQAIAQPGKIVS 888

Human   783 TAPYFNKSGPGAYESGIMVSKAVEIYIQGKLL--------KPAVVGIKIDVNSWIENFTKTSIRD 839
            ||||.:..|     :|.:::.|..|: :||..        :|..| :.:||
  Fly   889 TAPYLDAGG-----AGYIITIAHTIF-EGKAHALHSAQQDRPVAV-VALDV-------------- 932

Human   840 PCA---------GPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVN 895
            |.|         .|:|....    :.|::.:..|:||                 ..||:::.
  Fly   933 PYAFYYRLILEGTPICQLPH----IKCLLFEHEGYLL-----------------AHPSMLQP--- 973

Human   896 ISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPR 960
                        .::.:....|.:...|:.:|:.:  |:|..|            |.:..|.
  Fly   974 ------------ATLTKNQRRPHEHLTHKESYLAN--DMLNHG------------QLVRKLG--- 1009

Human   961 LLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEK-------LMNT 1018
                        .||...:   |.|..|.|:.   |.|.:|  ||   :.|||:       :..:
  Fly  1010 ------------CASYQNR---TLQRYYAFNT---SLSSIL--GN---VVHGERTKYAIALIRGS 1051

Human  1019 NLIFIMVESK----GTCPCDT--RLLI---QAEQTS-DGPNPCDMV----------------KQP 1057
            ||...::.|.    ..|||.|  |..:   :.:||. :.|..|.||                :|.
  Fly  1052 NLFAAVLNSSCDGGAFCPCSTIDRECLNCKRMDQTDCECPCECPMVGDSSSPSSLMYFANYTRQF 1116

Human  1058 RYRKGPDVCF-----DNNVLEDYTDCGGVSGL 1084
            .|...|...|     ...:|....:|.|.:|:
  Fly  1117 PYCPPPSEHFIALPPTTQLLSTLPNCPGSAGI 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CACNA2D1	XP_006716181.1	VWA_N	104..223	CDD:285584	22/148 (15%)
		vWA_VGCC_like	239..417	CDD:238740	52/217 (24%)
		Cache_1	446..536	CDD:280839	19/96 (20%)
		VGCC_alpha2	562..646	CDD:285647	23/84 (27%)
		RAMP_I_III	<655..835	CDD:304371	41/230 (18%)
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	34/119 (29%)
CG16868	NP_611469.1	Cache_1	559..627	CDD:280839	17/85 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810