DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CACNA2D1 and CG4587

DIOPT Version :9

Sequence 1:XP_006716181.1 Gene:CACNA2D1 / 781 HGNCID:1399 Length:1110 Species:Homo sapiens
Sequence 2:NP_001188817.2 Gene:CG4587 / 34921 FlyBaseID:FBgn0028863 Length:1271 Species:Drosophila melanogaster


Alignment Length:1314 Identity:320/1314 - (24%)
Similarity:547/1314 - (41%) Gaps:308/1314 - (23%)


- Green bases have known domain annotations that are detailed below.


Human     5 CLLALTL--TLFQS--LLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQ 65
            |.:|:.|  .:|:.  .:.....:|..|.. .:::|..|...||....:..:.:|::...: |..
  Fly     8 CFVAIVLGVLIFKMHIFVAFADQDEDIPHN-EVRNWALKFGVDLWEFGRQFTKMNEIKSRF-KDN 70

Human    66 DLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAE-----------KVQAAHQWREDFAS 119
            |:.....:....|.|:|| :::..:..:..|::||...||           :.::....::.:.:
  Fly    71 DIEVKRKDGIILLRELAA-EVKNFMDFKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDA 134

Human   120 NEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQ-----ISYQHAAVHIPTDIYEGSTIV 179
            ..:..|||...|       ..|::.:      |..|.|:     ::...:::.:|..:......|
  Fly   135 RRINEYNADGKL-------ADGARHM------DIRFMRRFERLPVNLSLSSILVPHGVDLDEPDV 186

Human   180 LNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWY 244
            .:.|.|:..||.:|:.|.|:||:|.||.|||:||..|.:|.:.|.......:|: ::|.|...|:
  Fly   187 KSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKL-IHDFRTHNWF 250

Human   245 IQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ-DVSCFQ-HL 307
            :|.|:||||::||:|.|.|::..:..|...:...:|:||.:|||||:.:|:...: .|.||: .:
  Fly   251 VQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRM 315

Human   308 VQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRA--NCNKIIMLFTDGGEERAQ 370
            |:|...|.:.:|.||..|..:...::..|..:||..|..||.|.|  .||:.|||.|:...|..:
  Fly   316 VRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHK 380

Human   371 EIFNKYN-KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPM 434
            ::..:|| ....||:||:.:|..:..|..:..|||.|||::.:|......|....:|..|:.|||
  Fly   381 DVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPM 445

Human   435 VLAGDKAKQVQWTNVYLDALELG----------LVITGTLPVFNITGQFENKTNLKNQLILGVMG 489
            ::. .....|.|:.|::.....|          ||.|.:.|||:.........||     |||:|
  Fly   446 IMY-QADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANL-----LGVVG 504

Human   490 VDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP-----------KP--IGVGIPTINL 541
            .||.:|:|:::.|:..|.||||.|.:|.||.||.||:|:|           ||  ..|.|..:.|
  Fly   505 TDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELEL 569

Human   542 RKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRT 606
                |..:...:.||:       |:..::..|:|..||..:.||..|..:....|.:.:......
  Fly   570 ----PETEFGNNNEPI-------EINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHR 623

Human   607 YTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPR 671
            |.:.|:..|.::||:|||.      |....|.::|...:..:...:|..|.||:.      :.| 
  Fly   624 YFYGPIEDTPFTLAIVLPE------KYGSHEFVSQQEIRHSRNNVTEYFKGDNWR------VHP- 675

Human   672 D--YCNDLKISD------NNTEFLLNFNE------------FIDR-------------KTP---- 699
            |  ||....:||      ::.|:.....|            |:.|             |:|    
  Fly   676 DWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPHH 740

Human   700 ---------NNPS---------------------CNADLINRVLLDAGFTNELVQNYWSK----- 729
                     |.|.                     |:..|:..::.||..|:.|.:|....     
  Fly   741 NMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSGKE 805

Human   730 -----------------QKNIKGVKARFVVTDGGITR-----VYPKEAGENW--QENPETYEDSF 770
                             ||.:  |...||.|..|:.|     ..|::..|..  ::|....:.|:
  Fly   806 DKHPIATLMAILKRQGYQKFV--VATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMDTSW 868

Human   771 YKRSLDN-----DNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPA--VVGIKIDVNSW 828
            |||::|.     |::|::.|:  .||.....:..:|:.:..|:::.:..|.|  |||::...:|.
  Fly   869 YKRAIDQHSVEPDSFVYSVPF--GSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSL 931

Human   829 IENFTKTSIRDPCAGPVCDCKRN--SDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMR 891
            .::|  .:|...|.| :..|||.  ||.:||.:||:.||::::...::|   |:|||:||.::|.
  Fly   932 AKHF--INITSACTG-MTGCKRTCASDNLDCYVLDNSGFVIISEEMEHT---GKFFGQIDGTIMD 990

Human   892 HLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWW------ATAAAWSILQ 950
            .||...:|......|||.||.....|...||       .:....::|.|      |.:|||    
  Fly   991 SLVQDRIYKRVTVNDYQGVCSDADNPYTAAG-------GILKPNRLGSWFFNHLLALSAAW---- 1044

Human   951 QFLLSLTFPRLLEA-----------------------------------VEMEDDDF--TASL-- 976
               ||| .|..|.|                                   |:.|.|:|  ||.:  
  Fly  1045 ---LSL-MPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEY 1105

Human   977 ---------------------SKQSCITEQTQYFFDNDSKSFSG--------VLDC--GNCSRIF 1010
                                 :.:.|......|....:..:..|        :.:|  ..|.|.|
  Fly  1106 TTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPF 1170

Human  1011 HGEKLMNTNLIFIMVESKGTCPCDTRLL-IQAEQTSDGPNPCDMVKQ---PRYRKGPDVCFDNNV 1071
            ..:|:.::|||.::|::  .|||.::.| |:..:.:.....|...:|   ...|:.|..|.:.:.
  Fly  1171 SVQKIPHSNLILLVVDT--LCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYHP 1233

Human  1072 LE-DYTDCGGVSGL 1084
            .| :...||..|.|
  Fly  1234 EEIEIQQCGRGSTL 1247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA2D1XP_006716181.1 VWA_N 104..223 CDD:285584 31/134 (23%)
vWA_VGCC_like 239..417 CDD:238740 63/182 (35%)
Cache_1 446..536 CDD:280839 38/112 (34%)
VGCC_alpha2 562..646 CDD:285647 20/83 (24%)
RAMP_I_III <655..835 CDD:304371 54/282 (19%)
CG4587NP_001188817.2 VWA_N 108..230 CDD:285584 31/134 (23%)
vWA_VGCC_like 245..428 CDD:238740 63/182 (35%)
Cache_1 456..544 CDD:280839 34/92 (37%)
VGCC_alpha2 590..>647 CDD:285647 17/62 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D69856at2759
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.020

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