DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP8 and lrp8

DIOPT Version :9

Sequence 1:	XP_005271230.1	Gene:	LRP8 / 7804	HGNCID:	6700	Length:	976	Species:	Homo sapiens
Sequence 2:	XP_005166314.1	Gene:	lrp8 / 557734	ZFINID:	ZDB-GENE-050506-134	Length:	1008	Species:	Danio rerio

Alignment Length:	980	Identity:	540/980 - (55%)
Similarity:	668/980 - (68%)	Gaps:	104/980 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
            |...|||..||||||.||||:.||||:||||.|:|||::|||||||.:||.|.||.|:..||:||
Zfish    23 GTNLDCESGQFQCRNGRCIPTPWRCDDDDDCSDNSDEENCPKKTCATTDFACKNGQCVPGRWRCD 87

Human   107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT---LCA 168
            ||.||||||||:::.|::|.||.||..||.::.|||..|||||||:|||.||||..||.   .|.
Zfish    88 GEPECPDGSDEADSACSRQTCPPEKFDCGGSTSKCVSLSWRCDGERDCENGADEEQCAADAKACP 152

Human   169 PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC---ADPACGPREFRCGGDGGGACIPERWVCDR 230
            ..||||.||.|:|..|||||||||||.|||..|   ....|||.||||   ....|||..|.||.
Zfish   153 AKEFQCRNRMCVAPTFVCDGDDDCGDRSDEEKCTAATASTCGPHEFRC---NDSECIPTPWSCDG 214

Human   231 QFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP 295
            ..||.|:|||:.|.|.|    .|.......:..:|.||||||:||.|:||||.|||||||||:||
Zfish   215 DPDCRDKSDESLERCSR----RTEPQKPHCSMGEFRCRSGECIHLNWKCDGDPDCKDKSDEANCP 275

Human   296 LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL------QVPPTFL------------- 341
            :.|||.|:||||||:|:...|.||:..||||.||||||:      :.|..|:
Zfish   276 VLTCRPDQFQCGDGSCIHGTKQCNKVHDCPDFSDEAGCVNRTNKCEGPLKFMCKSGECIDSSKVC 340

Human   342 ----------GNRRRPRGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDP 396
                      ....:..|||||..|||||||||.|.:|||||.||:|::|||:|||||||||::|
Zfish   341 DTIRDCKDWSDEPVKECGLNECAINNGGCSHICKDRQIGFECQCPSGYKLLDKKTCGDIDECENP 405

Human   397 DACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM 461
            :||||||:|.||.:|||||.|||||.:||.|| |.||||.|:||||||:|||||:|::|::::|.
Zfish   406 EACSQICINLKGDYKCECYEGYEMDPVTKTCK-AVGKSPYLMFTNRHEIRRIDLLKKDYTQVVPT 469

Human   462 LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 526
            |||.|||||:|.||::|||||.:|||:|||::||::..||..|||..||||||||:|||||:|||
Zfish   470 LKNAVALDVDVTTNKMYWCDLYHRKIFSAYINKANNSSEQITLIDTALHSPEGLAMDWVHKNIYW 534

Human   527 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTL 591
            ||||:||||||.|||.:|:.|....|.|||||||||.:|||||||||.||||||:|:||||||.|
Zfish   535 TDSGHKTISVANVDGKKRKVLIDTELGEPRAIAVDPRQGFMYWSDWGAQAKIEKAGMNGVDRQVL 599

Human   592 VSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 656
            ||:.|||||||.|||.|.||||||||||.:||:|.:|.||:.|:||.|.|.|||.:.:|||:|:|
Zfish   600 VSERIEWPNGIALDLSSSRLYWVDSKLHLISSVDLNGDNRRILLSSMDQLGHPFALTLFEDRVYW 664

Human   657 TDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAP 721
            ||||.|||:|.|||.|.::.:||::||||.|:|:||||:||:.||.|.:...||||||||||.||
Zfish   665 TDLEYEAIYSVNRLTGNDVVMLAQHLNNPLDVVVFHELRQPKVPDTCNMGNLPNGGCEYLCLRAP 729

Human   722 QISSHSPKYTCACPDTMWLGPDMKRCYRA-------------------PQSTST----------- 756
            ||:.|||||||||||:|.|||||:||...                   |.:|:|
Zfish   730 QITEHSPKYTCACPDSMELGPDMRRCVSVKPKTTAAPDPAASTASAAEPSTTATPTTSTPVTSAN 794

Human   757 --TTLASTMTRTVPATTRAP--GTTVHRSTYQN---HSTETPSLTAAVPSSVSVPRAPSISPST- 813
              ||.:...|.|.|.||.:.  .|:.|.||:::   |||.|.|..::.||:.:..:.|:.:.:|
Zfish   795 TPTTTSRLFTTTAPITTSSSSFSTSTHSSTHRSTSTHSTSTSSTASSQPSTTAHWKQPTSTETTT 859

Human   814 --------------LSPATSN--HSQHYANEDSKMGSTVTAAVIGIIVPI------VVIALLCMS 856
                          :..|.:|  |.....|:...:||.:|.||:||::||      |||.|:|..
Zfish   860 DHRHTSTTITHVNSIQGANANLSHRAGSGNDHFLLGSNITVAVLGIVIPIVPILATVVIGLMCTG 924

Human   857 GYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLG 921
            |||:||||:|:|||||||||||||||| |:|:||:||||:.|||||||....|..:|..|.|..|
Zfish   925 GYLVWRNWRRRNTKSMNFDNPVYRKTT-EDDDDEIHIGRSEQIGHVYPPVSGSARQPYLALPLGG 988

Human   922 ETREP 926
            ...:|
Zfish   989 SIPDP 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP8	XP_005271230.1	LDLa	47..81	CDD:238060	24/33 (73%)
		LDLa	85..117	CDD:197566	21/31 (68%)
		LDLa	127..163	CDD:238060	23/35 (66%)
		LDLa	206..240	CDD:197566	17/33 (52%)
		Ldl_recept_a	262..294	CDD:278486	23/31 (74%)
		Ldl_recept_a	298..333	CDD:278486	22/34 (65%)
		FXa_inhibition	353..387	CDD:291342	23/33 (70%)
		EGF_CA	389..419	CDD:214542	21/29 (72%)
		LY	458..493	CDD:214531	23/34 (68%)
		LY	502..544	CDD:214531	32/41 (78%)
		Ldl_recept_b	565..605	CDD:278487	32/39 (82%)
		LY	589..631	CDD:214531	29/41 (71%)
		Ldl_recept_b	652..691	CDD:278487	23/38 (61%)
		FXa_inhibition	710..747	CDD:291342	30/36 (83%)
lrp8	XP_005166314.1	LDLa	66..98	CDD:197566	21/31 (68%)
		Ldl_recept_a	107..144	CDD:278486	23/36 (64%)
		Ldl_recept_a	191..224	CDD:278486	17/35 (49%)
		Ldl_recept_a	240..274	CDD:278486	23/33 (70%)
		Ldl_recept_a	278..313	CDD:278486	22/34 (65%)
		LDLa	322..352	CDD:197566	2/29 (7%)
		FXa_inhibition	362..396	CDD:291342	23/33 (70%)
		EGF_CA	398..428	CDD:214542	21/29 (72%)
		LY	463..504	CDD:214531	25/40 (63%)
		LY	511..552	CDD:214531	32/40 (80%)
		Ldl_recept_b	573..613	CDD:278487	32/39 (82%)
		LY	597..639	CDD:214531	29/41 (71%)
		Ldl_recept_b	660..699	CDD:278487	23/38 (61%)
		FXa_inhibition	718..755	CDD:291342	30/36 (83%)
		IgaA	913..>985	CDD:284503	47/72 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342650
Domainoid	1	1.000	219	1.000	Domainoid score	I11465
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31250
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I1863
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		oto51345
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	LDO	PTHR24270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.310