DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP8 and LpR2

DIOPT Version :10

Sequence 1:NP_004622.2 Gene:LRP8 / 7804 HGNCID:6700 Length:963 Species:Homo sapiens
Sequence 2:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster


Alignment Length:982 Identity:351/982 - (35%)
Similarity:498/982 - (50%) Gaps:177/982 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    25 QLQHLAAAAADPLLGGQG---------------------PAK--------------------DCE 48
            ||:|||.|||:.:..|.|                     |.|                    .|:
  Fly   130 QLKHLAPAAANSISPGTGSGMGIGMGHFGSSINSVLNGNPLKFLNVSGKIGTPLDISLGLSNYCD 194

Human    49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDC--PKKTCADSDFTCDNGHCIHERWKCDGEE 109
            :.||||....|||..:.||...||.|||||  ::|  .:.||:...|.|.||.||..||.||.|.
  Fly   195 EKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDREN 259

Human   110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQC 174
            :|.||||||.:.|....|..|:.:|.....:|:|.||.||..|||..|:|||.|...|...||.|
  Fly   260 DCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCNRTCRSDEFTC 324

Human   175 GNRSCLAAVFVCDGDDDCGDGSDERGCADPA-CGPREFRCGGDGGGACIPERWVCDRQFDCEDRS 238
            ||..|:...|.||.||||||||||:.|.:.| ||...|.|   ..|.|||.:||||...||.:..
  Fly   325 GNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFAC---KSGPCIPNQWVCDGDSDCRNGE 386

Human   239 DEAAELCGRPGPGATSAPAACATASQFACRSGE--------CVHLGWRCDGDRDCKDKSDE--AD 293
            ||...               |..:....|::||        |:|..|.|||:.||.|..||  ::
  Fly   387 DEMQN---------------CTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSN 436

Human   294 CPLGTCRGDEFQCGD--------------------------------------------GTCVLA 314
            |...:||.|:|||.|                                            |.|:..
  Fly   437 CLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPN 501

Human   315 IKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 378
            .|.||:.:|||:|.||.....|:|||...||||.|.|.:|::|:.|.|..|::| .||.||.|||
  Fly   502 AKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDID 566

Human   379 ECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKN---CKAAAGKSPSLIFTNRHEVRRIDLVKR 440
            ||:.|..|||:|||..|.|||||..|| |.|| ||   |||:.|.: ||:...||::|:|.|.:.
  Fly   567 ECETPGICSQVCVNEIGAFKCECEAGY-MRLL-KNHTRCKASEGHA-SLLLARRHDIRKIALDRP 628

Human   441 NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 505
            ..:.::...|...|||....|..|:|.|::.:.||.|.:|:.:|   :.|::.:...:.:|||||
  Fly   629 EMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGND---RTVVLTKSSVTSDGLAVD 690

Human   506 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
            |::.|:|:||:...||.:...:|...:.|...:|..||:||:||:.|:|||||||...:||::|:
  Fly   691 WIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGM 755

Human   571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 635
            :|..|..:::.:::|||||||||:.:||||||.||:.:||.::.|..|..::.|.::|.|||.|.
  Fly   756 DGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSIT 820

Human   636 VFEDKVFWTDLENEAIFSANRLNGLEISILAEN--LNNPHDIVIFHELKQPRAPDACELSVQPNG 698
            .|||.|:|||.:.:|:|.||:.||:::..:...  |.:|..:.::|..:||...:.|: ||  ||
  Fly   821 TFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQ-SV--NG 882

Human   699 GCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR---APQSTSTTTLASTMTRTVPATTRA 760
            .|.:||||||:|:..||:.:||||..:.|.||...|..   .|....|..:..|:.::..:||:.
  Fly   883 HCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLGIPTVRPTAPMHRTIEQSSNSTTKL 947

Human   761 PGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANE----DSKMGS 821
            |         |:..:|||                      :...|.|:....:|:    |::..:
  Fly   948 P---------QDGYSETP----------------------VETKTGNNRTDTSNQVHKSDAESEN 981

Human   822 TVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQI 886
            ......:.:|..:...||:....|:::|...|. ..||||:||||.|||  ||...|....|.  
  Fly   982 DYVEIALHVIASLAGTALVASVIYVVYRRCTRA-VNSMNFENPVYHKTT--EDHFSLEKNGTP-- 1041

Human   887 GHVYPAA 893
             |:|.||
  Fly  1042 -HIYAAA 1047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP8NP_004622.2 LDLa 47..81 CDD:238060 17/35 (49%)
LDLa 85..117 CDD:197566 17/31 (55%)
LDLa 127..163 CDD:238060 16/35 (46%)
LDLa 206..240 CDD:197566 14/33 (42%)
Ldl_recept_a 262..294 CDD:395011 14/41 (34%)
Ldl_recept_a 298..333 CDD:395011 18/78 (23%)
FXa_inhibition 340..374 CDD:464251 15/34 (44%)
EGF_CA 376..406 CDD:214542 19/29 (66%)
LY 445..480 CDD:214531 11/34 (32%)
LDL-receptor class B 1 462..508 15/45 (33%)
LY 489..531 CDD:214531 14/41 (34%)
LDL-receptor class B 2 509..551 15/41 (37%)
LDL-receptor class B 3 552..595 22/42 (52%)
Ldl_recept_b 552..592 CDD:459654 19/39 (49%)
LY 576..618 CDD:214531 20/41 (49%)
LDL-receptor class B 4 596..639 19/42 (45%)
Ldl_recept_b 639..679 CDD:459654 13/41 (32%)
LDL-receptor class B 5 640..681 13/42 (31%)
FXa_inhibition 697..734 CDD:464251 19/36 (53%)
Clustered O-linked oligosaccharides 740..798 9/57 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..815 9/60 (15%)
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 15/30 (50%)
LDLa 235..267 CDD:197566 17/31 (55%)
LDLa 277..313 CDD:238060 16/35 (46%)
LDLa 356..388 CDD:197566 14/34 (41%)
LDLa 400..432 CDD:197566 12/31 (39%)
LDLa 442..476 CDD:238060 7/33 (21%)
LDLa 484..517 CDD:197566 9/32 (28%)
FXa_inhibition 527..562 CDD:464251 15/34 (44%)
EGF_CA 564..594 CDD:214542 20/30 (67%)
LY 675..715 CDD:214531 14/39 (36%)
LY 717..760 CDD:214531 20/42 (48%)
LY 763..803 CDD:214531 20/39 (51%)
Ldl_recept_b 782..828 CDD:459654 22/45 (49%)
Ldl_recept_b 824..866 CDD:459654 13/41 (32%)
FXa_inhibition 877..918 CDD:464251 22/43 (51%)

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