Protein Alignment LRP8 and cue

DIOPT Version :10

• Sequence 1: NP_004622.2
• Gene: LRP8 / 7804
• HGNCID: 6700
• Length: 963
• Species: Homo sapiens
• Sequence 2: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 662
• Identity: 130/662 - (19%)
• Similarity: 228/662 - (34%)
• Gaps: 237/662 - (35%)

Human   454 ALDVEVATNRIYWCDLSYR--KIYSAYMDK-ASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 515
            ||..:.:...||:.||.:|  .|:|...|. |::...::.:......|..|||.|.::.:::|:|
  Fly    63 ALTFDESEELIYFNDLKHRNGSIFSLKRDLIAANHVAEQTIARTGNESVGGLAYDPLNMNLFWSD 127

Human   516 SGNKTISVATVDGGRRRTL---FSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGLNGVDRQ 576
            :..:.|..|.:.|.....:   .|.....|..:|||..|..:||::.. ....:|:..|:|.:|.
  Fly   128 TEQRKIFFAPIHGSATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRT 192

Human   577 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS---GGNRKTLISSTDFLSHPFGIAVFE 638
            .::|.||:.|.||.:|.||.||:|:|.......|::.|   |.:|:.::.  |....|..:||..
  Fly   193 VIISSNIDMPRGIVVDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLK--DKHHEPLNLAVTN 255

Human   639 DKVFWTDLENEAIFSANRLNGLEIS---------------------------------------- 663
            |.::|||....|::|..::..::::
  Fly   256 DAIYWTDRTTRAVWSHPKVPVIKVTTTSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARG 320

Human   664 ILA-----ENLNNPH------------------------------------------------DI 675
            |:|     :.|...|                                                |:
  Fly   321 IVARTGFYQRLQKDHHCASIVRKVKERVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDL 385

Human   676 VI-------------------------FHELKQPRA-------PDACELSVQPNGGCEYLCL--- 705
            .|                         ..||..|:.       .:.|||||     |..|||
  Fly   386 CICPTGFKGSRCEIRECHNYCVHGTCQMSELAYPKCYCQPGFKGERCELSV-----CSGLCLNGG 445

Human   706 --PAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGT-TVHR 767
              ...:..:.:|  :|.||...    ...||.:  .||...:|...:.:..|......|. ::..
  Fly   446 HCRVSKDENEAP--SCECPAKF----GGARCEQ--NSTEICSLFCRLLKHEPEMYVPFGCHSICE 502

Human   768 STYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPA--TSNHSQHYANEDSKMGSTVTAAVIGI 830
            ...|::||           ::::|:...:. ..|:|.  ||              |.:...|:||
  Fly   503 ELAQDNST-----------NIAIPQYQHLE-VCLTPRVWTS--------------SVIIILVVGI 541

Human   831 IVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 895
            :..::::|::...   |.|.:|.|        .|..|||.....:     .||...|.. |..
  Fly   542 VSSLLLVAVIVQG---IRRLYKPK--------RPRIRKTFVVRKQ-----ARTNSAGDT-PLT-- 587

Human   896 SFDRPLWAEPC-----------LGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVK 949
              :|||..|.|           :.||       |..        :|:     |.:..||:....:
  Fly   588 --NRPLATEQCEITIENCCNMNICET-------PCF--------DPK-----LVEQTLSKSSCKE 630

Human   950 SKRVAL-SLEDD 960
            .|::.: ::|||
  Fly   631 DKKILIHNMEDD 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP8	NP_004622.2	LDLa	47..81	CDD:238060
		LDLa	85..117	CDD:197566
		LDLa	127..163	CDD:238060
		LDLa	206..240	CDD:197566
		Ldl_recept_a	262..294	CDD:395011
		Ldl_recept_a	298..333	CDD:395011
		FXa_inhibition	340..374	CDD:464251
		EGF_CA	376..406	CDD:214542
		LY	445..480	CDD:214531	9/27 (33%)
		LDL-receptor class B 1	462..508		14/48 (29%)
		LY	489..531	CDD:214531	10/41 (24%)
		LDL-receptor class B 2	509..551		10/44 (23%)
		LDL-receptor class B 3	552..595		13/43 (30%)
		Ldl_recept_b	552..592	CDD:459654	12/40 (30%)
		LY	576..618	CDD:214531	16/44 (36%)
		LDL-receptor class B 4	596..639		12/45 (27%)
		Ldl_recept_b	639..679	CDD:459654	12/157 (8%)
		LDL-receptor class B 5	640..681		11/158 (7%)
		FXa_inhibition	697..734	CDD:464251	8/41 (20%)
		Clustered O-linked oligosaccharides	740..798		9/58 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..815		10/63 (16%)
cue	NP_612113.2	TerD_like	48..>85	CDD:473128	7/21 (33%)
		YvrE	<73..>164	CDD:442613	23/90 (26%)
		LY	101..141	CDD:214531	9/39 (23%)
		Ldl_recept_b	167..208	CDD:459654	12/40 (30%)
		LY	193..237	CDD:214531	16/43 (37%)