Protein Alignment LRP8 and Lrp4

DIOPT Version :10

• Sequence 1: NP_004622.2
• Gene: LRP8 / 7804
• HGNCID: 6700
• Length: 963
• Species: Homo sapiens
• Sequence 2: NP_727914.1
• Gene: Lrp4 / 32552
• FlyBaseID: FBgn0030706
• Length: 2009
• Species: Drosophila melanogaster
• Alignment Length: 146
• Identity: 32/146 - (21%)
• Similarity: 52/146 - (35%)
• Gaps: 34/146 - (23%)

Human   197 SLAVVETEWRKRKASRKGA----EEEEEEEDDDSEEEIKAIRE---------RQKEELSKVTSNL 248
            |...|:...::||.....|    ::.|:|.|.|.:.:.|...|         :|.|||....:..
  Fly   156 SCYAVDKHVQQRKKYALDAFDSLKDLEKEVDRDEKSDAKDFEEATDKAEIVIQQIEELFNQYNRT 220

Human   249 GKMILKEEMEKSL-------PIRRKTRSLPDRTP-------FHTSLHSGTSKSSSLPSYGRTTLS 299
            .|.:|.:...|.:       .:......:|.|.|       .|.......:|||      :|...
  Fly   221 WKSVLLDMKPKRIDTTLWCGEVSLDVPGIPHRPPVFLVVAEHHLEERKRPTKSS------KTAPV 279

Human   300 RLQSTEFSPSGSEAGS 315
            :.:..|..|| |.||:
  Fly   280 KNEDVETVPS-SLAGT 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP8	NP_004622.2	LDLa	47..81	CDD:238060
		LDLa	85..117	CDD:197566
		LDLa	127..163	CDD:238060
		LDLa	206..240	CDD:197566	10/46 (22%)
		Ldl_recept_a	262..294	CDD:395011	7/38 (18%)
		Ldl_recept_a	298..333	CDD:395011	6/18 (33%)
		FXa_inhibition	340..374	CDD:464251
		EGF_CA	376..406	CDD:214542
		LY	445..480	CDD:214531
		LDL-receptor class B 1	462..508
		LY	489..531	CDD:214531
		LDL-receptor class B 2	509..551
		LDL-receptor class B 3	552..595
		Ldl_recept_b	552..592	CDD:459654
		LY	576..618	CDD:214531
		LDL-receptor class B 4	596..639
		Ldl_recept_b	639..679	CDD:459654
		LDL-receptor class B 5	640..681
		FXa_inhibition	697..734	CDD:464251
		Clustered O-linked oligosaccharides	740..798
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..815
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	10/35 (29%)
		LDLa	306..340	CDD:238060
		LDLa	347..390	CDD:238060
		LDLa	397..431	CDD:238060
		LDLa	442..476	CDD:238060
		LDLa	480..521	CDD:238060
		FXa_inhibition	576..604	CDD:464251
		LY	634..671	CDD:214531
		LY	680..714	CDD:214531
		LY	718..760	CDD:214531
		Ldl_recept_b	740..777	CDD:459654
		LY	761..803	CDD:214531
		LY	806..838	CDD:214531
		FXa_inhibition	882..912	CDD:464251
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271333
		NHL repeat	1038..1080	CDD:271333
		NHL repeat	1084..1119	CDD:271333
		FXa_inhibition	1185..1220	CDD:464251
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		LY	1292..1334	CDD:214531
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:464251
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:464251