DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP8 and LpR1

DIOPT Version :10

Sequence 1:NP_004622.2 Gene:LRP8 / 7804 HGNCID:6700 Length:963 Species:Homo sapiens
Sequence 2:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster


Alignment Length:956 Identity:342/956 - (35%)
Similarity:484/956 - (50%) Gaps:129/956 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCP--KKTCADSDFTCDNG 96
            ||..||.....|::.||||.:..|||..:.||.|.||.|||||.  :|.  :.||:...|.|.||
  Fly   125 PLGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNG 189

Human    97 HCIHERWKCDGEEECPDGSDES---------------------------------------EATC 122
            :||..:|:||.|.:|.|||||:                                       ||.|
  Fly   190 NCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAHC 254

Human   123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCD 187
            ..:.|..::.:|.....:|||.:|.||..|||..|:||..|...|...||.|||..|:...:.||
  Fly   255 RARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCD 319

Human   188 GDDDCGDGSDERGCADPAC-GPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251
            .||||||||||:.|....| ...|..|   ..||||.:|||||...||.|.|||      |....
  Fly   320 HDDDCGDGSDEKECPVVPCDSVAEHTC---TNGACIAKRWVCDGDPDCSDGSDE------RSCAN 375

Human   252 ATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDE--ADCPLGTCRGDEFQCGD----- 308
            .|.....| .:.::.|:.. .|:|..|.|||||||.|..||  |:|...|||.|:|||||     
  Fly   376 VTKTTTPC-LSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIP 439

Human   309 -------------------------------------------GTCVLAIKHCNQEQDCPDGSDE 330
                                                       |.||...|.|::.:|||||.||
  Fly   440 GHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDE 504

Human   331 AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 394
            .....|:|||...||||.|.|.|||:|..|.|..|::|. |::.|.||:||:.|..|||||||..
  Fly   505 PAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEI 569

Human   395 GYFKCECYPGYEMDLLTKN---CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 456
            |.|||||..||..|  .||   |||:.|.: ||:...||::|:|.|.....:.::...|...|||
  Fly   570 GGFKCECEAGYMRD--PKNHTRCKASEGHA-SLLLARRHDIRKIALDHMEMTSIVNSTKAATALD 631

Human   457 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI 521
            ....|..|:|.|::.:.||.|.:|:.:   |:.|::.:...:.:||||||::.|:|:||:...||
  Fly   632 FVFRTGMIFWSDVTTQSIYKAPIDEGN---EKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTI 693

Human   522 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWP 586
            .:...:|...:.|...:|..||:||:||:.|:|||||||...:||::|::|..|.|::|.:::||
  Fly   694 ELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWP 758

Human   587 NGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 651
            |||||||:.:|:||||.||:.:||.::.|..|..::.|.::|.|||.|..|||.|:|||.:.:|:
  Fly   759 NGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAV 823

Human   652 FSANRLNGLEISILA--ENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 714
            |.||:..|.::..:.  ..|.:|..:.::|..:||...:.|: ||  ||.|.:||||||:|:..|
  Fly   824 FKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQ-SV--NGHCSHLCLPAPRINERS 885

Human   715 PKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPS 779
            |:.:||||..:.|..|...|...|......|......:|.| ..::|...:.......|:.....
  Fly   886 PRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKP-RPKSPRRRLPTGVQVGHADIRIE 949

Human   780 LTAAVPSSVSVPRAPSISPSTLSPATSNHSQ----HYANEDSKMGSTVTAAVIGIIVPIVVIALL 840
            :...:..|..:|..|:...:...| ..||:|    ...:|....|......:..:....|::::|
  Fly   950 INDDLQLSTRLPLLPTTFVADQRP-VKNHTQIEKTTTPSEQPDSGFIALVVIASLSGFAVLLSVL 1013

Human   841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQI 886
            .:.||   |...::...||||:||:|||||..||...|.....|:|
  Fly  1014 LLIGY---RYCSKRRINSMNFENPIYRKTTTTEDHFSLRKNLPARI 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP8NP_004622.2 LDLa 47..81 CDD:238060 18/35 (51%)
LDLa 85..117 CDD:197566 16/31 (52%)
LDLa 127..163 CDD:238060 14/35 (40%)
LDLa 206..240 CDD:197566 16/34 (47%)
Ldl_recept_a 262..294 CDD:395011 15/34 (44%)
Ldl_recept_a 298..333 CDD:395011 21/82 (26%)
FXa_inhibition 340..374 CDD:464251 16/34 (47%)
EGF_CA 376..406 CDD:214542 19/29 (66%)
LY 445..480 CDD:214531 11/34 (32%)
LDL-receptor class B 1 462..508 15/45 (33%)
LY 489..531 CDD:214531 14/41 (34%)
LDL-receptor class B 2 509..551 15/41 (37%)
LDL-receptor class B 3 552..595 24/42 (57%)
Ldl_recept_b 552..592 CDD:459654 21/39 (54%)
LY 576..618 CDD:214531 21/41 (51%)
LDL-receptor class B 4 596..639 18/42 (43%)
Ldl_recept_b 639..679 CDD:459654 12/41 (29%)
LDL-receptor class B 5 640..681 12/42 (29%)
FXa_inhibition 697..734 CDD:464251 18/36 (50%)
Clustered O-linked oligosaccharides 740..798 8/57 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..815 10/64 (16%)
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 16/31 (52%)
LDLa 178..210 CDD:197566 16/31 (52%)
LDLa 219..254 CDD:238060 2/34 (6%)
LDLa 259..295 CDD:238060 14/35 (40%)
LDLa 343..373 CDD:238060 18/38 (47%)
LDLa 383..415 CDD:197566 13/32 (41%)
Ldl_recept_a 423..459 CDD:395011 9/35 (26%)
LDLa 476..504 CDD:197566 10/27 (37%)
FXa_inhibition 514..549 CDD:464251 16/34 (47%)
EGF_CA 551..581 CDD:214542 19/29 (66%)
LY 662..702 CDD:214531 14/39 (36%)
LY 704..747 CDD:214531 20/42 (48%)
LY 749..790 CDD:214531 21/40 (53%)
Ldl_recept_b 769..815 CDD:459654 21/45 (47%)
FXa_inhibition 864..905 CDD:464251 21/43 (49%)

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