DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment znrf3 and znrf3

DIOPT Version :9

Sequence 1:	NP_001072864.1	Gene:	znrf3 / 780325	XenbaseID:	XB-GENE-5937936	Length:	853	Species:	Xenopus tropicalis
Sequence 2:	NP_001295484.1	Gene:	znrf3 / 556813	ZFINID:	ZDB-GENE-070705-263	Length:	866	Species:	Danio rerio

Alignment Length:	905	Identity:	510/905 - (56%)
Similarity:	589/905 - (65%)	Gaps:	130/905 - (14%)

- Green bases have known domain annotations that are detailed below.

Frog    12 LVWLWVLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRFSRAGATISAEGEIVQMHP 76
            ||.||||     |..|||:|||||||||||||||||.|:||.|||||||||||||||||||||||
Zfish    18 LVLLWVL-----GSVLAKDTAFVEVVLFESSPNGDYTTYTTGLQGRFSRAGATISAEGEIVQMHP 77

Frog    77 LGLCNNNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRGATAVIFDVSDNPDAVEQL 141
            |||||||||||||||||||||||||||:||. ||||||||||||||||||||||||:||||::||
Zfish    78 LGLCNNNDEEDLYEYGWVGVVKLEQPELDPS-CLTVLGKAKRAVQRGATAVIFDVSENPDAIDQL 141

Frog   142 NQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVC 206
            ||..||||||||||:||.||:||||||||||.||||||||||| |||||||||||||||||||||
Zfish   142 NQVSEDPLKRPVVYVKGTDAVKLMNIVNKQKVARARIQHRPPR-PTEYFDMGIFLAFFVVVSLVC 205

Frog   207 LILLIKIKLKQRRSQNSMNRMAVQALEKMETRKFKAKGKVPREGSCGGLDTLSSSSTSDCAICLE 271
            |||||||||||||||:||||||:||||||||.|||||.|..||.|||..|::|||||||||||||
Zfish   206 LILLIKIKLKQRRSQSSMNRMAIQALEKMETCKFKAKFKGQREASCGASDSVSSSSTSDCAICLE 270

Frog   272 KYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGHGPVCVE-NSSNRGRQQQQ 335
            |||||||||||||.|||||:||||||||:|||||||||||:||||..|.||:: .:...||   |
Zfish   271 KYIDGEELRVIPCAHRFHKKCVDPWLLQHHTCPHCRHNIIDQKKGNPGAVCLDPGNPVHGR---Q 332

Frog   336 QRVILPVHYPGRVQRTGPIAAYPTRTSMGPHGNPITVLTVERPLEPDLYPARTPTFLAGYRPVSL 400
            |||:|||||||||.|.|.:.||||||||.|||||||||||::..|..|||::: :|:.||..:.|
Zfish   333 QRVVLPVHYPGRVHRAGQVTAYPTRTSMDPHGNPITVLTVDQHPEQGLYPSQS-SFIRGYPALHL 396

Frog   401 DHASSGHHCDLEHPPYPAPPAGHGFRRAKYSGRGFNNGTCYSQYETMYQHYYFQGLSYPHQQEVG 465
            ||..:.|||.|||.. ||.|..|.|:|.|:.||.|:...|:|||||||||||||||::|..:
Zfish   397 DHTLNPHHCGLEHRG-PAYPQTHTFKRPKFHGRNFSRAACFSQYETMYQHYYFQGLTFPQPE--- 457

Frog   466 GSQAPRVVENGHNHSFHSGNNMLYQPAPTLMHMAPPSS--VG--------SCYLHSQHQHRSVCS 520
             .|....:..|||..|..|  :||   ||::||||.||  :|        |||    |.||||||
Zfish   458 -GQPSNGLHKGHNRPFQPG--LLY---PTVVHMAPASSSRLGDSGSTSGLSCY----HGHRSVCS 512

Frog   521 GYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEASNQGVYGSCSTFRSSLSSDFDPYVYRSRS 585
            |||||.|.|||||    ||.|.|.|||||||||||.|||||||||||||||||||:|||||||:|
Zfish   513 GYLADCPGSDSSS----SSGQCHCSSSDSMLDCTEVSNQGVYGSCSTFRSSLSSDYDPYVYRSKS 573

Frog   586 PARTGGGDAPGCGGEGG------------TGSGRGRVECRSHQTFPNSPSRDRLSSCSMEMNYSS 638
            |.|       |..||.|            :....|.::|..........|.|:||:||:|.|.|:
Zfish   574 PCR-------GSAGEAGAVFSAAPPADDTSAPVSGMIDCLQPPGGACYSSGDQLSNCSLEPNCSN 631

Frog   639 NSSLERRGAVISS------GTVPDASVSISQGGGKDRRGPEKG--CTCCFQ---------RQAGD 686
            :||:|.|....::      |.|.:.|.:..:..|      |:|  |.|||:         .:.|:
Zfish   632 HSSVETRELTSTTSAGPLEGNVAERSHNSVKPCG------EQGVACNCCFEVPKLNLERKSKEGE 690

Frog   687 PSSDC---TNLYLGPDPHQTSGPSSSGGLYSVTSSILHRTDPGTVLGHPSRPCCLYEE------- 741
            ....|   |         :....:||...|||::..|...|.   :.:...|||.|.|
Zfish   691 DRGRCRWAT---------EAQAVASSQNFYSVSTEQLPSPDH---VSYDGLPCCFYTEMTVHRGG 743

Frog   742 -NHGSCYNEDYAVSIQYALAEAAAAAAAAAVAGCEAGQPIPIIPEDPGYDGGLE-------CVGH 798
             ||   |.||.:|:||||..::........   ||..|.|||||||...:.||.       ....
Zfish   744 ANH---YAEDCSVNIQYAQTDSDGCMGQGC---CELAQRIPIIPEDTDCELGLGPEPQTSLLSSR 802

Frog   799 VSWEMEGEEEEEEV--LYCQEGPCCALA------EETRAL----CRSTGKEGAGSTTGQD 846
            ::.|.|.....|:.  |:...|.|....      ||.|||    |.:..:....||:..|
Zfish   803 LTTEREERTSSEDTCDLFFTSGQCRGQVYQQPQDEEARALFSSKCNAVSETQGSSTSSFD 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:375639	93/105 (89%)
		RING-H2_ZNRF3	266..309	CDD:319713	39/42 (93%)
		RING-H2 finger (C3H2C3-type)	266..306	CDD:319713	36/39 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..629		13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..673		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..713		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..853		3/13 (23%)
znrf3	NP_001295484.1	zf-RING_2	265..306	CDD:290367	38/40 (95%)
znrf3	NP_001295484.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..811		6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I5396
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H46592
Inparanoid	1	1.050	874	1.000	Inparanoid score	I2940
OMA	1	1.010	-	-		QHG40703
OrthoDB	1	1.010	-	-		D114304at7742
OrthoFinder	1	1.000	-	-		FOG0013402
OrthoInspector	1	1.000	-	-		oto79780
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010