DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment znrf3 and Rnf43

DIOPT Version :9

Sequence 1:	NP_001072864.1	Gene:	znrf3 / 780325	XenbaseID:	XB-GENE-5937936	Length:	853	Species:	Xenopus tropicalis
Sequence 2:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus

Alignment Length:	941	Identity:	260/941 - (27%)
Similarity:	371/941 - (39%)	Gaps:	256/941 - (27%)

- Green bases have known domain annotations that are detailed below.

Frog     8 GG----LPLVWLW---------------VLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTE 53
            ||    |.::|.|               ||.|....|..|::.|.:.|:..:..|.|  |.:.|
  Rat     3 GGHQLQLAVLWPWLLMATLHAGFGHTGLVLAAAVESERSAEQKAIIRVIPLKMDPTG--KLNLT- 64

Frog    54 LQGRFSRAGATISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKR 118
            |:|.|:.......|||:::|.|||.|||.:|:::| |.|::.:||||.|...|:|||::..||:.
  Rat    65 LEGVFAGVAEVSPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRRAPRPCLSLASKARM 128

Frog   119 AVQRGATAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPP 183
            |.:|||:||:||::::..|.|||.|.|  .|.:|||.:.|.||.|||..|.|.:.|...|:.:.|
  Rat   129 AGERGASAVLFDITEDRSAAEQLQQPL--GLTKPVVLIWGSDAEKLMEFVYKNRKAYVWIELKEP 191

Frog   184 RQPTEYFDMGIFLAFFVVVSLVCLILLIKIKLKQRRSQ-NSMNRMAVQALEKMETRKF-----KA 242
            .....| |:.|.|.....|.::.|..:::|:.:...|: :.:.:...:|:.::.||::     :|
  Rat   192 PAWANY-DVWILLTVVGTVFVIILASVLRIRCRPHPSRPDPLQQRTARAISQLATRRYQASCRRA 255

Frog   243 KGKVPREGSCGGLDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCR 307
            :.:.|..||       ||||...||||||::.:|:|||||.|.|.||:.||||||.|:.|||.|.
  Rat   256 RAEWPDSGS-------SSSSAPVCAICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCM 313

Frog   308 HNIIE-----QKKGGHGPVCVENSSNRGRQQQQQRVILPVHYPGRVQRTGPIAAY--PTRTSMGP 365
            .||:|     |..|          ::...|:..:|:.|...:||.       |.|  |:...:||
  Rat   314 FNIVEGDSFSQALG----------ASPSYQEPGRRLHLIRQHPGH-------AHYHLPSAYLLGP 361

Frog   366 HGNPITVLTVERPLEPDLYPARTPTFLAGYRPVSLDHASSGHHCDLEHPPYPAPPAGHGFRRAKY 430
            ..|.:......||..|...|:      .|.|...|..||  |....|...:.|...||.:.:
  Rat   362 SRNSVAQTPRPRPFLPSQEPS------MGSRHQRLPRAS--HLRAPEEQQHLAVSPGHPYAQ--- 415

Frog   431 SGRGFNNGTCYSQYETMYQHYYFQGLSYPHQQEVGGSQAPRVVENGHNHSFHSGNNMLYQPAPTL 495
             |.|.|...|.||:.                                            ...|..
  Rat   416 -GWGPNRLRCTSQHP--------------------------------------------NACPVA 435

Frog   496 MHMAPP---SSVGSCYLHSQHQHRSVCSGYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEAS 557
            :..|.|   |..|..|...:       ||||||.|.|||||...      |.|||||:::||:.|
  Rat   436 LRRARPHESSGSGESYCTER-------SGYLADGPASDSSSGPC------HGSSSDSVVNCTDIS 487

Frog   558 NQGVYGSCSTFRSSLSSDFDPYVYRSRSPARTGGGDAPGCGGEGGTGSGR--------GRVECRS 614
            .|||:||.|||||||||||||.||.|...|..|....|..     |...|        |..:..|
  Rat   488 LQGVHGSSSTFRSSLSSDFDPLVYCSPEGALQGKEVQPSM-----TSRPRSLDSVVPTGETQVSS 547

Frog   615 H---------------QTFPNSP--------SRDRLSSCSMEMNYSSNSSLERRGAVISSGTVPD 656
            |               |.....|        ||...|...:|.:...........||.|....|.
  Rat   548 HIHYHRHRHHHYKKQFQWHSRKPGLETGVPQSRPAASHTQLEPSLPDQQLTTPNPAVSSMLPNPQ 612

Frog   657 ASVSISQGGGKDRRGPEKGCTCCFQRQAGDPSSDCTNLYLG--------PDPHQTSGPSSSGGLY 713
            ...::::        |..|..   :..:..||.:.:.|.|.        |...:..|||.:....
  Rat   613 RPRALTE--------PAPGLA---EAVSPSPSPNPSLLNLQKSNLPVRYPQRKRRGGPSEALPTS 666

Frog   714 SVTSSILHRTDP-----GTVLGHPSRPCCLYEENH------------------GSCYNEDYAVSI 755
            ......:|...|     ...|.:|..|     |.|                  |.||:....|.:
  Rat   667 QPQDLTVHTACPVPPHYSPSLAYPWPP-----EVHPLIFRPPGLDRRLLHDVPGPCYSSSQPVWL 726

Frog   756 QYALAEAAAAAAAAAVAGCEAGQPI-PIIPEDPGYDGGLECVGHVSWEMEGEEEEE------EVL 813
            .                 ....||: |.:|.:          ||..|..:..|:..      :||
  Rat   727 Y-----------------LNPRQPLGPCLPGE----------GHSKWSFDTPEDRRCPYSHCQVL 764

Frog   814 YCQEGPCCA----LAEETRALCRSTGKEGAG 840
            ..|.|.|..    ..:||.:.|...|:...|
  Rat   765 PAQPGECSGKQVFWEKETISGCWRAGENSQG 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:375639	49/105 (47%)
		RING-H2_ZNRF3	266..309	CDD:319713	27/42 (64%)
		RING-H2 finger (C3H2C3-type)	266..306	CDD:319713	26/39 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..629		13/76 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..673		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..713		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..853		2/7 (29%)
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	48/104 (46%)
		RING-H2_RNF43	270..316	CDD:319712	27/45 (60%)
		dnaA	598..>743	CDD:237605	29/187 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920