DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment znrf3 and plr-1

DIOPT Version :9

Sequence 1:	NP_001072864.1	Gene:	znrf3 / 780325	XenbaseID:	XB-GENE-5937936	Length:	853	Species:	Xenopus tropicalis
Sequence 2:	NP_499473.2	Gene:	plr-1 / 176575	WormBaseID:	WBGene00023404	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	473	Identity:	117/473 - (24%)
Similarity:	192/473 - (40%)	Gaps:	107/473 - (22%)

- Green bases have known domain annotations that are detailed below.

Frog    26 SLAKETAFVE---VVLFESSPNGDYKTH---TTELQGRFSRAGATISAEGEIVQMHPLGLCN--- 81
            :||.:..|.|   :.:..::.|.| :|.   |.:|.|.||..|:.....|:|||:.....|:
Worm    29 TLASQFKFAEKADIFVTHTNINED-RTQDEKTIKLSGTFSPVGSNYETGGDIVQVSSFRACDARR 92

Frog    82 NNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRGATAVIFDVSDNPDAVEQLNQGLE 146
            ...:..::|:  |.||..:..|.....|:.:..:|:.|.:.||.|:|...:..   ||:..:
Worm    93 KGLDNTVFEH--VPVVFYDDVEKFLTGCVALDNQARFAEKSGAMALIVGPASR---VERTTR--- 149

Frog   147 DPL-----KRPVVYMKGMDAIKLMNIVN--KQKGARAR-----IQHRPPR-------QPTEYFDM 192
             |:     |.||:.:......:|.:.:.  .::||..:     |..:|.:       :||.   :
Worm   150 -PMMIGGSKIPVIVLDDEQTERLRSELRSASERGAVTKLRISFIDEKPTKVLKLQVFRPTV---L 210

Frog   193 GIFLAFFVVVSLVCLILLIKIKLKQRRSQNSMNR------MAVQALEKMETRKFK---------- 241
            .|.|...:::.:|.:.||:.:|:   |.|.:|:|      :|..||.|||.|.|:
Worm   211 NITLLGLLIILIVFVSLLVVVKI---RCQPTMHRELWLRALARTALTKMEIRSFQKEKNVEAGQK 272

Frog   242 -------AKGKVPREGSC---------GGLDTLSSSSTSD----CAICLEKYIDGEELRVIPCTH 286
                   |:.|..|..|.         |.|.:::.||:..    |.||||:|.:|.||||:.|.|
Worm   273 KKTSSTFARLKQHRSSSSRHSSYLAVFGSLTSVAQSSSHSAQERCVICLEEYEEGTELRVLFCGH 337

Frog   287 RFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGHGPVCVENSSNRGRQQQQQRVILPVHYPGRVQRT 351
            .||.:|||||||....||.|:.:::.:    |.|. |::......:......:||...|.....:
Worm   338 EFHPKCVDPWLLSKRRCPLCQFDVVYK----HYPK-VDSPEKLSGRSDDTTSLLPRTSPSEDLPS 397

Frog   352 GPIA--------------AYPTRTSMGPHGNPITVLTVER----PLEPDLYPARTPTF---LAGY 395
            .|.:              ..|:.|....|..|....|..|    |....|.......|   :.||
Worm   398 APSSRSTRLTRPYRTTHHLIPSSTRPSSHQRPSLQPTAPRTRSCPRRRQLRSRNQIDFSIRIGGY 462

Frog   396 -RPVSLDHASSGHHCDLE 412
             ..||..||......::|
Worm   463 SSDVSSSHAEQSRSFEIE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:375639	23/120 (19%)
		RING-H2_ZNRF3	266..309	CDD:319713	25/42 (60%)
		RING-H2 finger (C3H2C3-type)	266..306	CDD:319713	24/39 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..629
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..713
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..853
plr-1	NP_499473.2	zf-rbx1	305..358	CDD:289448	26/52 (50%)
plr-1	NP_499473.2	zf-RING_2	317..357	CDD:290367	24/39 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	95	1.000	Inparanoid score	I4003
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm21830
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.000