Protein Alignment PTP4A1 and PRL-1

DIOPT Version :9

• Sequence 1: NP_001372194.1
• Gene: PTP4A1 / 7803
• HGNCID: 9634
• Length: 184
• Species: Homo sapiens
• Sequence 2: NP_001260487.1
• Gene: PRL-1 / 34952
• FlyBaseID: FBgn0024734
• Length: 176
• Species: Drosophila melanogaster
• Alignment Length: 129
• Identity: 74/129 - (57%)
• Similarity: 96/129 - (74%)
• Gaps: 0/129 - (0%)

Human     6 RPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPF 70
            ||||..:.||.|:||||..|::.|:|.:|.||||..|.|:|||||.:|:|..:|.:||.|.|..|
  Fly    11 RPAPALIEYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAF 75

Human    71 DDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIR 134
            :||..|..|:||:|..::|.|:::.|..|:|||||||||||||||||||||.|:|||.||:.||
  Fly    76 EDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMIR 139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP4A1	NP_001372194.1	PTP_DSP_cys	1..135	CDD:421693	74/129 (57%)
		Interaction with ATF5. /evidence=ECO:0000250	97..132		28/34 (82%)
		Phosphate binding	105..110		4/4 (100%)
PRL-1	NP_001260487.1	PTP-IVa	10..163	CDD:350350	74/129 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4796
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2587
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54094
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001421
OrthoInspector	1	1.000	-	-		otm41940
orthoMCL	1	0.900	-	-		OOG6_101823
Panther	1	1.100	-	-	O	PTHR23339
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5007
SonicParanoid	1	1.000	-	-		X788
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.000