DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tlk2 and Tlk

DIOPT Version :9

Sequence 1:	NP_001072711.1	Gene:	tlk2 / 780168	XenbaseID:	XB-GENE-5747259	Length:	697	Species:	Xenopus tropicalis
Sequence 2:	NP_001138153.1	Gene:	Tlk / 318206	FlyBaseID:	FBgn0283657	Length:	1489	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	361/792 - (45%)
Similarity:	455/792 - (57%)	Gaps:	185/792 - (23%)

- Green bases have known domain annotations that are detailed below.

Frog    23 VGVAKAPLNSESSNQSLCSLGSLSDKELEQTP---EKKQNDQRNRKRKADPYETSQGKNTP-RGH 83
            ||:...||          ||.|:.    :|||   :::|..|:.::::..|..||.....| ..|
  Fly   687 VGLGGHPL----------SLASIQ----QQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPH 737

Frog    84 KISDYFEFA-CGSGPGTSPGRSVPPVARSSPQHSLSNPLPLPSQQCSPPSTAPVNPEHSCASFKH 147
            ::....... .|.|.|...|.:|          .:..|||.|     ||...|.          .
  Fly   738 QLGSLGVVGMVGVGVGVGVGVNV----------GVGPPLPPP-----PPMAMPA----------A 777

Frog   148 ISVQHRCTQSDLTMDKISALENSKSSDLEKKEGRIDDLLRVNCDLRRQMDEQKKMLEKYKERLNR 212
            |....:.||:::::.::    ..:.::.|..:.::|::.|::.:.:.|:...:|.::::|..:.:
  Fly   778 IITYSKATQTEVSLHEL----QEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAK 838

Frog   213 CVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINT 277
            |:.:.||||.|||..||...|.|.||:|||||.|.|.|.||:|.|.||||||||.|.::||.|..
  Fly   839 CIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITA 903

Frog   278 QREEIERQRKMLAKRKPPAMGQ----TPPANNEQKQ----------------------------- 309
            :||||:||:|.|.|::|...|:    ....||:|:|
  Fly   904 EREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGP 968

Frog   310 -------------------------------------------------RKNKT---------NG 316
                                                             |.|.|         ||
  Fly   969 GSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNG 1033

Frog   317 AENE----------------------------------------------ALTLAEYHEQEEIFK 335
            ....                                              |.|..||:|.:||.|
  Fly  1034 GGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILK 1098

Frog   336 LRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSE 400
            ||...||||:|::|.|:|:|||.|||||||||||.|||.|:|.:||.||||||||.|||:|||||
  Fly  1099 LRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSE 1163

Frog   401 VYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF 465
            |:|||||.||||||.|:|||||:|:::||.||.|||.|||.|||.|||||:|||||.|.:|.:||
  Fly  1164 VHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSF 1228

Frog   466 CTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTA 530
            |||||||:|:||||||||||.:.|:||||||||:|:|||||||||||:||||||||||||..|..
  Fly  1229 CTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNV 1293

Frog   531 CGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVI 595
            |||||||||||||:|||::||...||:|||||||||||||||||||||.|||||:||||||||||
  Fly  1294 CGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVI 1358

Frog   596 FYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQL 660
            |||||||:|||||||||..||:||||||||||||..||.|:.|||:|||.|||||||||:||..|
  Fly  1359 FYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFAL 1423

Frog   661 ACDPYLLPHIRK 672
            |...|:.|.|.|
  Fly  1424 ARHEYIQPPIPK 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tlk2	NP_001072711.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..136		26/113 (23%)
		Smc	145..>385	CDD:224117	107/376 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..315		11/116 (9%)
		STKc_TLK2	380..688	CDD:270943	228/293 (78%)
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	209/267 (78%)
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	209/266 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	462	1.000	Domainoid score	I475
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4993
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm47518
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3972
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.040