Protein Alignment DDR1 and Eph

DIOPT Version :10

• Sequence 1: XP_054186331.1
• Gene: DDR1 / 780
• HGNCID: 2730
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 153/549 - (27%)
• Similarity: 234/549 - (42%)
• Gaps: 152/549 - (27%)

Human   437 LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPP 501
            :.|.:|..:|.|::.|...::      .:....:..|:::.|.||.:|.|.
  Fly   640 IAGAIVTGVLFLVIFIIATVY------FMRSKHQDDLDKKSTNHLPLPLDY-------------- 684

Human   502 YQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYM 566
                  ..|..:|....|....|.|:                   ..||.:..       |..|:
  Fly   685 ------ASNEVNSMDTTPIVKKLHLN-------------------VTTPLFGN-------SRSYV 717

Human   567 EPEKPGAPLLPPPPQNSVPHYA---EADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRL 628
            :|.      ....|..::..:|   :|:.:|::.:.||
  Fly   718 DPH------TYEDPNQAIREFAREIDANYITIEAIIGG--------------------------- 749

Human   629 RFKEKLGEGQFGEVHLCEVDSPQDLV-SLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRND 692
                    |:||:|....:..|.:.| .:|            ||:|.|:|.:::.|      |.|
  Fly   750 --------GEFGDVCRGRLKIPPNFVQDID------------VAIKTLKPGSSEKA------RCD 788

Human   693 FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAA 757
            ||.|..||.:...||:|.|.||..:.:|:.:||:|||||.|:.||..:.          |..|..
  Fly   789 FLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVND----------GKFQTL 843

Human   758 QGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-YAGDYY 821
            |        |:.:...|||||.||:.:|:||||||.||.||......||||||:||.: .|.|.|
  Fly   844 Q--------LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAY 900

Human   822 RVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFR 886
            ..:| ..:|:||.|.|.|...|||:|||||::||.|||| |....:|:...:::.||::..:.:|
  Fly   901 TTRG-GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEV-MSYGERPYWNWSNQDVIKSIEKGYR 963

Human   887 DQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTKPLSPTQLVLWMGSS 951
                   |..|..||:.||:|||.||.::...||.|:.:...|  |.|..:|    |.:|....|
  Fly   964 -------LPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL--DNLARQP----QSLLTTRPS 1015

Human   952 PPSSSHPL--GKGGEKYRIDTGHGPLEHL 978
            |.|..:.:  |:.|:...|.|... |||:
  Fly  1016 PESDGNHILDGQRGQNIFISTDLW-LEHI 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDR1	XP_054186331.1	FA58C	78..202	CDD:238014
		PTKc_DDR1	622..931	CDD:133227	111/310 (36%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020
		EphA2_TM	640..738	CDD:464211	23/155 (15%)
		PTKc_EphR	736..1002	CDD:270629	116/347 (33%)
		SAM_1	1029..1092	CDD:425739	6/16 (38%)