Protein Alignment DDR1 and InR

DIOPT Version :10

• Sequence 1: XP_054186331.1
• Gene: DDR1 / 780
• HGNCID: 2730
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Alignment Length: 515
• Identity: 148/515 - (28%)
• Similarity: 213/515 - (41%)
• Gaps: 142/515 - (27%)

Human   491 NNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARP---------PRGPG 546
            ||...|        .|.|..||..    |||. ::....||:|     .:|         |....
  Fly  1218 NNTESP--------VRVRWTPPVD----PNGE-IVTYEVAYKL-----QKPDQVEEKKCIPAADF 1264

Human   547 PPTPAWAKPTNTQAYS-----------GDYMEPEKPGAPLLPPP--------------------- 579
            ..|..:....|...||           ||:.|.|.  ..:.|||
  Fly  1265 NQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEH--IKVEPPPSYAKVFFWLLGIGLAFLIVSL 1327

Human   580 ------------PQNSV-------PHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPR 625
                        |.|.:       |.||....:                        |...:..|
  Fly  1328 FGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYI------------------------PDDWEVLR 1368

Human   626 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSR 690
            ..:.....||:|.||.|:        :.:...||.|   |.....|:|.:..:||..      .|
  Fly  1369 ENIIQLAPLGQGSFGMVY--------EGILKSFPPN---GVDRECAIKTVNENATDR------ER 1416

Human   691 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAE------- 748
            .:||.|..:|......:::||||||.:..|..::.:.|:.|||..:|.||:.|::...
  Fly  1417 TNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNR 1481

Human   749 -GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMS 812
             |..|:   .|.||  |..:..:|.:||.||.|||...|||||||.|||:|.::.|:||.||||:
  Fly  1482 IGVTGN---VQPPT--YGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMT 1541

Human   813 RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQV 877
            |::|..||||...:.:||:|||..|.:..|.:::||||::|||.|||:..|. |||:..|::|||
  Fly  1542 RDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLA-AQPYQGLSNEQV 1605

Human   878 IENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTK 937
            :    .:..|.|   .:.||..||..|::||.|||...|..||.|..:..:|.....|::
  Fly  1606 L----RYVIDGG---VMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQ 1658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDR1	XP_054186331.1	FA58C	78..202	CDD:238014
		PTKc_DDR1	622..931	CDD:133227	115/316 (36%)
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	20/89 (22%)
		PTKc_InsR_like	1364..1652	CDD:173625	115/317 (36%)