Protein Alignment DDR1 and Ddr

DIOPT Version :10

• Sequence 1: XP_054186331.1
• Gene: DDR1 / 780
• HGNCID: 2730
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Alignment Length: 1045
• Identity: 332/1045 - (31%)
• Similarity: 483/1045 - (46%)
• Gaps: 190/1045 - (18%)

Human    13 PEGSGAMGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWS-DSTA 76
            ||...|:|...|.:.:.:                ..|:.||||:...|.|..|:|||:.. .:..
  Fly    86 PETPAAVGSNGLLAEMPI----------------GTCKQALGMESGAIADFQITASSAHDMGNVG 134

Human    77 ARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYS 141
            .:|:||:..:..|||||...|.....|||||||..:|||:.:.||||...|.|:|::.:|.:.|.
  Fly   135 PQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYW 199

Human   142 RDG-RRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLW 205
            |.| ::|:.|:...|:||:.||.:....|...|.|.:.|..||.||.:....:||||.|:.||.|
  Fly   200 RPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAW 264

Human   206 RDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPG 270
            .:|::||:.|.|  |.....:.|:|.||||:..|.....|||||.||..|.|:||.... .:..|
  Fly   265 EEGIVSYSIPKG--MQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNFRADIN-GLGKG 326

Human   271 YDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEP 335
            |:::||.|.:.....||:.|||:.:|...|:.:|.|||.:...::....:..|..| ...:.|||
  Fly   327 YEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIG-GRHFSGEP 390

Human   336 MRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFIS-DVVNNSSPAL--GGT 397
            ::.:...:|....||.|::.|..|:.|::|....||..|::.|||:||| .||.|.:..|  |..
  Fly   391 VQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDELANGEK 455

Human   398 FPPAPWWP-----------PGPPPTNFSSLELEPR---GQQPVAKAEGSPTAILIGCLVAIILLL 448
            ......:|           .|...:..::..:.|:   .|:|    |.|...::|..|..||:||
  Fly   456 QSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEP----ETSFVGVIITVLGTIIMLL 516

Human   449 LLIIALMLWR-LHWRRL---LSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEP---- 505
            :..|.|::.| .|.|..   |...:.....:.|..:..:...|.:.:|.....:...|.||
  Fly   517 VAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNAN 581

Human   506 ---------------RPRGNP---------------PHSAPCVPN----GSALLLSNPAYRLLLA 536
                           |...:|               ||....:||    ||.         ....
  Fly   582 MYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSG---------CGTG 637

Human   537 TYARPPRGPGP----------------------PTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPP 579
            |...|.||..|                      |.|:...|...:.|........|| .|:.||.
  Fly   638 TGTGPGRGSSPEFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKP-MPVAPPG 701

Human   580 PQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPR----------------------VD 622
            .|:|             |....:|.|......|.||.|.|.                      .:
  Fly   702 SQSS-------------GSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINEERANCQVQE 753

Human   623 FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSL 687
            |||..|...||||.|.|||:||||.:          .||.     .||||..|||.|..:.
  Fly   754 FPRQSLVIVEKLGSGVFGELHLCETN----------VLNA-----TLVAVATLRPGANDHL---- 799

Human   688 FSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYME-NGDLNQFLSAHQLEDKAAEGAP 751
              |.:|..:.|.:::|.|||:.||:|.|::|:|:|::.||.. .|||||||..|..|.
  Fly   800 --RKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAET------- 855

Human   752 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG--MSRN 814
             .|..|: .::|:..|:::|.||||||::|..:||||||||||:|::|....:|:...|  ::|:
  Fly   856 -SGLMAK-KSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRS 918

Human   815 LYAGDYYRVQG-----RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD 874
            .||.||.:::|     ...:||||||||.:|:|||||.||||:|.|.|||:|...|.||:..|:|
  Fly   919 AYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSD 983

Human   875 EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTKPL 939
            :.||||.|..:||......|..||.||:.:|:||..||.|:...||.|.::|.:|....|..||.
  Fly   984 KSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRKNLGFKPQ 1048

Human   940 SPTQL 944
            :.|.:
  Fly  1049 THTHM 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDR1	XP_054186331.1	FA58C	78..202	CDD:238014	50/124 (40%)
		PTKc_DDR1	622..931	CDD:133227	135/316 (43%)
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	60/151 (40%)
		PTKc_DDR	753..1040	CDD:270644	135/316 (43%)