Protein Alignment DDR1 and Ddr1

DIOPT Version :10

• Sequence 1: XP_054186331.1
• Gene: DDR1 / 780
• HGNCID: 2730
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_031610.1
• Gene: Ddr1 / 12305
• MGIID: 99216
• Length: 911
• Species: Mus musculus
• Alignment Length: 920
• Identity: 854/920 - (92%)
• Similarity: 874/920 - (95%)
• Gaps: 12/920 - (1%)

Human    19 MGPEALSS-LLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRL 82
            ||...||| |||||||..|||||||||||||||||||||||||||||||.|||||||||||||||
Mouse     1 MGTGTLSSLLLLLLLVTIGDADMKGHFDPAKCRYALGMQDRTIPDSDISVSSSWSDSTAARHSRL 65

Human    83 ESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRW 147
            |||||||||||||.|||||||||||||:|||||||||||||||||||||||||||||||||||||
Mouse    66 ESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRW 130

Human   148 MGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSY 212
            |.||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 MDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSY 195

Human   213 TAPVGQTMYLSEA-VYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGW 276
            ||||||||.|||. |:||||||||:|.||||||||||||||||||||||:|||||||||||||||
Mouse   196 TAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGW 260

Human   277 SNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLG 341
            ||.||.:|||||||||||||.||.|||||||||||||||||||||||:|||||||||||:||.||
Mouse   261 SNQSFPTGYVEMEFEFDRLRTFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWEGEPVRHALG 325

Human   342 GNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPP 406
            |:||||||||:||||||.|.|||||||||||||||||||||||||||:||    .||||||||||
Mouse   326 GSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDVVNDSS----DTFPPAPWWPP 386

Human   407 GPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERR 471
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   387 GPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERR 451

Human   472 VLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLA 536
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
Mouse   452 VLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGTPPHSAPCVPNGSALLLSNPAYRLLLA 516

Human   537 TYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGG 601
            ||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
Mouse   517 TYARPPRGPGPPTPAWAKPTNTQACSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGG 581

Human   602 NTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGH 666
            ||||||||||||||||||||||||||||||||||||||||||||||:.||||||.|||::|.|||
Mouse   582 NTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGH 646

Human   667 PLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENG 731
            |||||||||||||||||      ||||||||||||||||||||||||||||||||||||||||||
Mouse   647 PLLVAVKILRPDATKNA------RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENG 705

Human   732 DLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNC 796
            ||||||||.|||:||.:|..||.::.|||||||||||||.|||||||||||||||||||||||||
Mouse   706 DLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNC 770

Human   797 LVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 861
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   771 LVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 835

Human   862 MLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 926
            ||||:||||||||||||||||||||||||||||||||||||.||||||||||||.||||||:|||
Mouse   836 MLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLH 900

Human   927 RFLAEDALNT 936
            ||||:|||||
Mouse   901 RFLADDALNT 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDR1	XP_054186331.1	FA58C	78..202	CDD:238014	119/123 (97%)
		PTKc_DDR1	622..931	CDD:133227	281/308 (91%)
Ddr1	NP_031610.1	FA58C	58..185	CDD:238014	122/126 (97%)
		DS-like domain. /evidence=ECO:0000250	193..369		156/175 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	468..496		26/27 (96%)
		PPxY motif	479..482		2/2 (100%)
		Protein Kinases, catalytic domain	602..905	CDD:473864	281/308 (91%)