DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opcml and DIP-delta

DIOPT Version :9

Sequence 1:	NP_001072487.1	Gene:	opcml / 779942	XenbaseID:	XB-GENE-5831850	Length:	346	Species:	Xenopus tropicalis
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	319	Identity:	92/319 - (28%)
Similarity:	138/319 - (43%)	Gaps:	27/319 - (8%)

- Green bases have known domain annotations that are detailed below.

Frog    17 MFGAALTVLLSITGVPVRSGDAGFPKAMDNVTVRQGDSAILRCTVDN-RVTRVAW--LNRSTILY 78
            ||...:|.|::    .|...:..|.:.:.||||..|..|.|.|.|:: ...:|||  ::|..||.
  Fly    27 MFLIYMTNLVT----HVMMDEPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILT 87

Frog    79 TGNDKWSIDPRVVLLANTKSQYSIEIQNVDIYDEGPYTCSVQTDNHPKTSRV-HLIVQVAPQILN 142
            ......|..|| ..:..|.:.:.:.:......|.|.|.|.|.|  :|..|:| :|.|.|.|.||:
  Fly    88 IHRHVISRIPR-YSITYTDNTWLLHVNQAHQDDRGYYMCQVNT--NPMISQVGYLQVVVPPNILD 149

Frog   143 IS---SDITVNEGSTVALRCLATGRPEPAVTWRHFTG-------KSHRFVSDDEYLEITGITRDQ 197
            |.   |.:.|.|...:.:.|.|.|.|.|.:.||...|       |....|.|.:.|.:|.::|::
  Fly   150 IESTPSSVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDADVLPLTKVSRNE 214

Frog   198 SGQYECSAANDVSAPDIRKVRVTVNYPPYI-SDTRNTGASLGQKGILRCSASAVPLAEFQWYREE 261
            .|.|.|.|.|.|.....:::.:.|.:.|.| ...:..||..|....:.|...|.|.|...|....
  Fly   215 MGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNS 279

Frog   262 TRLANG----LDGVRIENKDHMSILTFFNVSEKDYGNYTCVASNKLGNSNASVILYAGP 316
            ..:...    .|......:.||. ||..|:...|:|||.|::.|.||.:..|:.:|..|
  Fly   280 VMVLPSKKYKTDYTENSYRAHMK-LTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opcml	NP_001072487.1	Ig	46..134	CDD:325142	29/91 (32%)
		Ig_3	138..207	CDD:316449	25/78 (32%)
		ig	228..312	CDD:278476	23/87 (26%)
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	30/94 (32%)
		Ig	145..238	CDD:416386	27/92 (29%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	0/7 (0%)
		Ig	242..333	CDD:416386	25/91 (27%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	3/10 (30%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10578
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060