Protein Alignment LUZP1 and ZIP1

DIOPT Version :9

• Sequence 1: NP_001136018.1
• Gene: LUZP1 / 7798
• HGNCID: 14985
• Length: 1076
• Species: Homo sapiens
• Sequence 2: NP_010571.1
• Gene: ZIP1 / 851879
• SGDID: S000002693
• Length: 875
• Species: Saccharomyces cerevisiae
• Alignment Length: 535
• Identity: 118/535 - (22%)
• Similarity: 226/535 - (42%)
• Gaps: 108/535 - (20%)

Human     3 EFTSYKETASSR-------HLRFKLQS----LSRRLDELEEATKNLQKAEDELLDLQDKVIQAEG 56
            |.:|..||...:       :|..|:.|    :::.::||....|.|      ::.:|::::.:.|
Yeast   393 ELSSNTETMLKQQYEDIKENLEQKMSSSKDEMAKTINELSVTQKGL------IMGVQEELLTSSG 451

Human    57 S-NSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEI---ERLQKRM 117
            : .:::::|:...||.:|     |:..:.|::...|        |||.:..|:||   ...::|:
Yeast   452 NIQTALVSEMNNTRQELL-----DDASQTAKNYASL--------ENLVKAYKAEIVQSNEYEERI 503

Human   118 AELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASE 182
            ..||......|..||   |:..||..:....:.:..:||...:::.::...|..|.:..::|::|
Yeast   504 KHLESERSTLSSQKN---QIISSLGTKEAQYEDLVKKLEAKNIEISQISGKEQSLTEKNENLSNE 565

Human   183 -------LEKLKSLTLSFVS--ERKYLNEKE------KENEKLIKELTQKLEQNKKMNRDYTRNA 232
                   ||||.:|.::..|  |.|..::.|      .||:.|.:.:.|.:|..:...:|:|...
Yeast   566 LKKVQDQLEKLNNLNITTKSNYENKISSQNEIVKALVSENDTLKQRIQQLVEIKENEQKDHTTKL 630

Human   233 SNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEK 297
            ...::|:              |..:|..::.::...:|...:.:|...:|..:.|...:.:.:..
Yeast   631 EAFQKNN--------------EQLQKLNVEVVQLKAHELELEEQNRHLKNCLEKKETGVEESLSD 681

Human   298 LKTQIKHFESLEEELKKMKSKNNDLQDNY--LSEQNKN--KLLASQLEEIKLQIKKQKELENGEV 358
            :||..:....|:.|.:.:.::..:||||.  |.|..||  :.:.||..|::.:||:.:|::|.:
Yeast   682 VKTLKQQVIVLKSEKQDITAEKLELQDNLESLEEVTKNLQQKVQSQKRELEQKIKELEEIKNHK- 745

Human   359 EGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSS 423
            ..|.   |.||....||    .|::.....|...|.|              ||      :..:.|
Yeast   746 RNEP---SKKGTQNFTK----PSDSPKKNATTSNLFP--------------NN------SAAIHS 783

Human   424 PSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAW 488
            |.   ::..|..|:..|..:.::||.|..|.| ..||.|........||.:...|    ...|..
Yeast   784 PM---KKCPKVDHISKSRINSSKETSKFNDEF-DLSSSSNDDLELTNPSPIQIKP----VRGKIK 840

Human   489 KGTS--KPGTESGLK 501
            ||::  ||...|..|
Yeast   841 KGSNCMKPPISSRKK 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LUZP1	NP_001136018.1	Lebercilin	104..303	CDD:292252	43/216 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..291		6/44 (14%)
		mycoplas_twoTM	262..>369	CDD:275320	25/110 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..546		35/146 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	569..600
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..746
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..819
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	862..913
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	929..998
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1076
ZIP1	NP_010571.1	Smc	<208..>748	CDD:224117	83/391 (21%)
		SMC_prok_B	479..>749	CDD:274008	64/295 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000