DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LUZP1 and Naus

DIOPT Version :9

Sequence 1:	NP_001136018.1	Gene:	LUZP1 / 7798	HGNCID:	14985	Length:	1076	Species:	Homo sapiens
Sequence 2:	NP_001286565.1	Gene:	Naus / 37076	FlyBaseID:	FBgn0034308	Length:	609	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	129/696 - (18%)
Similarity:	219/696 - (31%)	Gaps:	279/696 - (40%)

- Green bases have known domain annotations that are detailed below.

Human    34 TKNLQKAEDELLDLQDKV------IQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLM 92
            ||.||..:......:||:      |..|.|..:..||:|| ||                    ::
  Fly   119 TKRLQPNDPYAAIFRDKIALNGNLISRESSTQAAQAEMEV-RQ--------------------II 162

Human    93 KEKLEEEENLTRELKSE--------IERLQKRMAELEKLEEAFSRSKNDCTQ---LCLSLNEERN 146
            ::::|::..:..:.::.        .|.|:.....|::|||...:.:|...|   :...|..|||
  Fly   163 EQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKHENTTAQGDDITYGLELERN 227

Human   147 LTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLI 211
               |:..:||..|.:|.::|..   |.|.:::|..|..:.|.:.|..::|||.:..|..|..|..
  Fly   228 ---KLKQDLEEERAQVAKMEKD---LKKLQETLEYERNRQKQIVLLLIAERKKILMKYIEEGKRS 286

Human   212 KELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE 276
            ::|.|.|.:.|:.:...........:..||:|:.:.....:.|..||  :.:.|..:.|.|
  Fly   287 EDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERK--VLFAKLAKEELR---- 345

Human   277 NEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLE 341
                       ||:|.||:..|::        |.|
  Fly   346 -----------VKELEQELNALRS--------EHE------------------------------ 361

Human   342 EIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNRE 406
                .:|||::|                         .||.:||:...||:
  Fly   362 ----ALKKQQQL-------------------------GGSGSSVAAAKARQ-------------- 383

Human   407 FALNNENYSLSNRQVSSPSFTN-----RRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKK 466
                     .|:...::|...|     :..|..|.|.|   ||.|
  Fly   384 ---------FSDDACATPPMVNIAKIVQPTATVSSMPV---SGPQ-------------------- 416

Human   467 SREQPSVLSRYPPAAQEHSKAWKGTSKPGTESG----LKGKVEKTTRTFSDTTHGSVPSDPLGRA 527
                 :.::|.....|....|...|:..||.:.    |...:..|| |.:.||:.:
  Fly   417 -----TGIARSIAPGQNIRSAGIATAPTGTATAAIAPLTAVLNHTT-TITTTTNNT--------- 466

Human   528 DKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADN 592
                                     |.::||..|.:||..|     ::..::...:.|..:....
  Fly   467 -------------------------TTSSNSNSSGSIGVAA-----TAAAVAASVETAATVTVPM 501

Human   593 SCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKP 657
            ..|.|.:|...                         ||.|.:.              ::.|.:
  Fly   502 VAPPSPSPAKM-------------------------QPTATIQ--------------RAPGGK-- 525

Human   658 DSDDDLDIASLVTAKLVNTTITPEPEPKP---QPNSREKAKTRGAP 700
                   .|:|..|..::.|.||.|.|.|   .|.:...|..||||
  Fly   526 -------YAALAAAAALDQTTTPHPHPVPIAVPPVTVPPAGARGAP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUZP1	NP_001136018.1	Lebercilin	104..303	CDD:292252	49/209 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..291		8/44 (18%)
		mycoplas_twoTM	262..>369	CDD:275320	15/106 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..546		28/196 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..600		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..746		12/29 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..819
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..913
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..998
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1076
Naus	NP_001286565.1	CortBP2	78..274	CDD:286770	42/181 (23%)
Naus	NP_001286565.1	Angiomotin_C	189..381	CDD:289044	59/281 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23166
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100